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Targeting Toll-like receptors with small molecule agents
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PubMed
title
Targeting Toll-like receptors with small molecule agents
(English)
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stated in
PubMed
main subject
toll-like receptor
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author
Xiaohui Wang
object named as
Xiaohui Wang
series ordinal
1
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author name string
Christina Smith
series ordinal
2
1 reference
stated in
Crossref
Hang Yin
series ordinal
3
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
21 June 2013
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stated in
PubMed
published in
Chemical Society Reviews
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stated in
PubMed
volume
42
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stated in
PubMed
issue
12
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PubMed
page(s)
4859-66
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PubMed
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MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to Gram-positive and Gram-negative bacteria and their cell wall components
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Possible involvement of toll-like receptor 4/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences
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Opioid activation of toll-like receptor 4 contributes to drug reinforcement
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28 September 2017
Structural biology of the Toll-like receptor family
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28 September 2017
Toll-like receptor modulators: a patent review (2006-2010).
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28 September 2017
Targeting TLR4 signaling by TLR4 Toll/IL-1 receptor domain-derived decoy peptides: identification of the TLR4 Toll/IL-1 receptor domain dimerization interface.
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28 September 2017
Small-molecule inhibitors of the TLR3/dsRNA complex
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Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studies
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Application of a novel in silico high-throughput screen to identify selective inhibitors for protein-protein interactions
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28 September 2017
Toll-like receptor 4 in CNS pathologies
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28 September 2017
Targeting Toll-like receptors: emerging therapeutics?
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Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model
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28 September 2017
A peptide antagonist of the TLR4-MD2 interaction
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28 September 2017
Taxanes inhibit human TLR4 signaling by binding to MD-2.
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28 September 2017
Paclitaxel binding to human and murine MD-2.
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28 September 2017
Cell-penetrating TIR BB loop decoy peptides a novel class of TLR signaling inhibitors and a tool to study topology of TIR-TIR interactions
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28 September 2017
Application of beta-lactamase enzyme complementation to the high-throughput screening of toll-like receptor signaling inhibitors
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28 September 2017
The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4.
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28 September 2017
Toll-like receptor 4 region Glu24-Lys47 is a site for MD-2 binding: importance of CYS29 and CYS40.
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28 September 2017
A novel cyclohexene derivative, ethyl (6R)-6-[N-(2-Chloro-4-fluorophenyl)sulfamoyl]cyclohex-1-ene-1-carboxylate (TAK-242), selectively inhibits toll-like receptor 4-mediated cytokine production through suppression of intracellular signaling
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28 September 2017
Discovery of novel and potent small-molecule inhibitors of NO and cytokine production as antisepsis agents: synthesis and biological activity of alkyl 6-(N-substituted sulfamoyl)cyclohex-1-ene-1-carboxylate
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28 September 2017
Novel TLR4-antagonizing peptides inhibit LPS-induced release of inflammatory mediators by monocytes
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28 September 2017
Taking toll: lipid A mimetics as adjuvants and immunomodulators
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28 September 2017
Structure-activity relationships in human Toll-like receptor 2-specific monoacyl lipopeptides.
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Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product
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31 May 2018
TAK-242 selectively suppresses Toll-like receptor 4-signaling mediated by the intracellular domain
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21 January 2018
TAK-242 (resatorvid), a small-molecule inhibitor of Toll-like receptor (TLR) 4 signaling, binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules.
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A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis
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21 January 2018
Characterization of heme as activator of Toll-like receptor 4.
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21 January 2018
Opioid-induced glial activation: mechanisms of activation and implications for opioid analgesia, dependence, and reward.
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28 November 2018
Structure-activity relationship of synthetic toll-like receptor 4 agonists
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Toll-like receptor 2 antagonists. Part 1: preliminary SAR investigation of novel synthetic phospholipids
1 reference
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based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1039/C3CS60039D
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PMC publication ID
3665707
1 reference
stated in
PubMed
PubMed publication ID
23503527
1 reference
stated in
PubMed
ResearchGate publication ID
236056065
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