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The role of inflammasome in Alzheimer's disease
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scholarly article
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PubMed
review article
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Europe PubMed Central
title
The role of inflammasome in Alzheimer's disease
(English)
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main subject
Alzheimer's disease
1 reference
based on heuristic
inferred from title
inflammasome complex
1 reference
based on heuristic
inferred from title
author name string
Li Liu
series ordinal
1
1 reference
stated in
Crossref
Christina Chan
series ordinal
2
1 reference
stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
May 2014
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stated in
PubMed
published in
Ageing Research Reviews
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stated in
PubMed
volume
15
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stated in
PubMed
page(s)
6-15
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stated in
PubMed
cites work
NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice
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Pro-inflammatory interleukin-18 increases Alzheimer's disease-associated amyloid-β production in human neuron-like cells
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The inflammasomes
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21 March 2017
Alzheimer's Disease
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PubMed Central
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Inflammasome components NALP 1 and 3 show distinct but separate expression profiles in human tissues suggesting a site-specific role in the inflammatory response
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Neuropathologic changes in Alzheimer's disease
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IPAF inflammasome is involved in interleukin-1β production from astrocytes, induced by palmitate; implications for Alzheimer's Disease
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Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke
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Palmitate induces transcriptional regulation of BACE1 and presenilin by STAT3 in neurons mediated by astrocytes
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Signaling dynamics of palmitate-induced ER stress responses mediated by ATF4 in HepG2 cells
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28 September 2017
The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective
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28 September 2017
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28 September 2017
Acute neurodegeneration and the inflammasome: central processor for danger signals and the inflammatory response?
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28 September 2017
Inflammation: a new candidate in modulating adult neurogenesis
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28 September 2017
Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons
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28 September 2017
Neuroinflammatory mechanisms in Parkinson's disease: potential environmental triggers, pathways, and targets for early therapeutic intervention
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28 September 2017
Interleukin-1beta and caspase-1: players in the regulation of age-related cognitive dysfunction
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28 September 2017
Activation of microglia acidifies lysosomes and leads to degradation of Alzheimer amyloid fibrils
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28 September 2017
Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease
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28 September 2017
Interferon-gamma and tumor necrosis factor-alpha regulate amyloid-beta plaque deposition and beta-secretase expression in Swedish mutant APP transgenic mice
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28 September 2017
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28 September 2017
Mediterranean diet and risk for Alzheimer's disease
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28 September 2017
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28 September 2017
Human amyloid beta-induced neuroinflammation is an early event in neurodegeneration
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28 September 2017
Obesity in middle age and future risk of dementia: a 27 year longitudinal population based study
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28 September 2017
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28 September 2017
Dietary fatty acids intake: possible role in cognitive decline and dementia
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28 September 2017
S100B-induced microglial and neuronal IL-1 expression is mediated by cell type-specific transcription factors
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28 September 2017
Prevention of cold-associated acute inflammation in familial cold autoinflammatory syndrome by interleukin-1 receptor antagonist
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28 September 2017
The microglial phagocytic role with specific plaque types in the Alzheimer disease brain
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28 September 2017
Interleukin-18 as a potential target in inflammatory arthritis
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28 September 2017
Inflammation in central nervous system injury
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28 September 2017
Results of a high-resolution genome screen of 437 Alzheimer's disease families
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28 September 2017
Increased A beta peptides and reduced cholesterol and myelin proteins characterize white matter degeneration in Alzheimer's disease
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28 September 2017
A cell biological perspective on Alzheimer's disease
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28 September 2017
Immune function of astrocytes
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28 September 2017
Regulation of IL-18 production by IFN gamma and PGE2 in mouse microglial cells: involvement of NF-kB pathway in the regulatory processes
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28 September 2017
Costimulatory effects of interferon-gamma and interleukin-1beta or tumor necrosis factor alpha on the synthesis of Abeta1-40 and Abeta1-42 by human astrocytes
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28 September 2017
Cytokine and growth factor involvement in long-term potentiation
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28 September 2017
Synergistic induction of nitric oxide by beta-amyloid and cytokines in astrocytes
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28 September 2017
Cellular and molecular biology of Alzheimer's disease and animal models
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28 September 2017
Uptake and transport of fatty acids into the brain and the role of the blood-brain barrier system.
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28 September 2017
Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist
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28 September 2017
Elevated circulating tumor necrosis factor levels in Alzheimer's disease
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28 September 2017
Turnover of resident microglia in the normal adult mouse brain
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28 September 2017
Effects of experimental cerebral malaria in memory, brain-derived neurotrophic factor and acetylcholinesterase activity [correction for acitivity] in the hippocampus of survivor mice
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31 May 2018
Differential requirements for NAIP5 in activation of the NLRC4 inflammasome
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31 May 2018
Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes
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31 May 2018
Interleukin-18 stimulates synaptically released glutamate and enhances postsynaptic AMPA receptor responses in the CA1 region of mouse hippocampal slices
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31 May 2018
The inhibition of long-term potentiation in the rat dentate gyrus by pro-inflammatory cytokines is attenuated in the presence of nicotine
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31 May 2018
Increased amyloid- levels in APPSWE transgenic mice treated chronically with a physiological high-fat high-cholesterol diet
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31 May 2018
Inhibition of human caspases by peptide-based and macromolecular inhibitors
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31 May 2018
Astrocytes are mainly responsible for the polyunsaturated fatty acid enrichment in blood-brain barrier endothelial cells in vitro.
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31 May 2018
Delayed phospholipid degradation in rat brain after traumatic brain injury.
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31 May 2018
In vivo and in vitro evidence supporting a role for the inflammatory cytokine interleukin-1 as a driving force in Alzheimer pathogenesis
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31 May 2018
Interleukin-1 in Alzheimer's disease and multi-infarct dementia: neuropsychological correlations
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31 May 2018
Interleukin-6 and α-2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices
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31 May 2018
Nod-like receptor protein 1 inflammasome mediates neuron injury under high glucose.
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28 November 2018
Human astrocytes express a novel NLRP2 inflammasome.
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28 November 2018
Antimalarial drug artemisinin extenuates amyloidogenesis and neuroinflammation in APPswe/PS1dE9 transgenic mice via inhibition of nuclear factor-κB and NLRP3 inflammasome activation
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28 November 2018
Palmitate-activated astrocytes via serine palmitoyltransferase increase BACE1 in primary neurons by sphingomyelinases
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28 November 2018
A review: inflammatory process in Alzheimer's disease, role of cytokines.
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28 November 2018
Degraded mitochondrial DNA is a newly identified subtype of the damage associated molecular pattern (DAMP) family and possible trigger of neurodegeneration.
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28 November 2018
Environmental enrichment ameliorated high-fat diet-induced Aβ deposition and memory deficit in APP transgenic mice.
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28 November 2018
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28 November 2018
Increased hippocampal neurogenesis in the progressive stage of Alzheimer's disease phenotype in an APP/PS1 double transgenic mouse model
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28 November 2018
Interleukin-18 promoter polymorphisms and risk of late onset Alzheimer's disease.
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28 November 2018
Inhibition of the inflammasome complex reduces the inflammatory response after thromboembolic stroke in mice.
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28 November 2018
High-fat diet aggravates amyloid-beta and tau pathologies in the 3xTg-AD mouse model.
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28 November 2018
Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study
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28 November 2018
Cytokine IL-1 beta but not IL-1 alpha promoter polymorphism is associated with Alzheimer disease in a population from the Canary Islands, Spain
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28 November 2018
Japanese Encephalitis Virus infection induces IL-18 and IL-1beta in microglia and astrocytes: correlation with in vitro cytokine responsiveness of glial cells and subsequent neuronal death
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28 November 2018
Interleukin-18 produced by peripheral blood cells is increased in Alzheimer's disease and correlates with cognitive impairment.
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28 November 2018
Altered plasma cytokine levels in Alzheimer's disease: correlation with the disease progression.
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28 November 2018
Glial expression of interleukin-18 and its receptor after excitotoxic damage in the mouse hippocampus.
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28 November 2018
Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients.
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28 November 2018
Does NSAID use modify cognitive trajectories in the elderly? The Cache County study.
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28 November 2018
Palmitate modulates intracellular signaling, induces endoplasmic reticulum stress, and causes apoptosis in mouse 3T3-L1 and rat primary preadipocytes
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28 November 2018
Gene expression alterations in the sphingolipid metabolism pathways during progression of dementia and Alzheimer's disease: a shift toward ceramide accumulation at the earliest recognizable stages of Alzheimer's disease?
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28 November 2018
Palmitic acid-treated astrocytes induce BACE1 upregulation and accumulation of C-terminal fragment of APP in primary cortical neurons.
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28 November 2018
Chitotriosidase and inflammatory mediator levels in Alzheimer's disease and cerebrovascular dementia.
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28 November 2018
Impact of different saturated fatty acid, polyunsaturated fatty acid and cholesterol containing diets on beta-amyloid accumulation in APP/PS1 transgenic mice.
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28 November 2018
Palmitic and stearic fatty acids induce Alzheimer-like hyperphosphorylation of tau in primary rat cortical neurons
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28 November 2018
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28 November 2018
Myocardial insulin resistance associated with chronic hypertriglyceridemia and increased FFA levels in Type 2 diabetic patients.
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28 November 2018
P38 MAP kinase is activated at early stages in Alzheimer's disease brain.
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28 November 2018
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28 November 2018
Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis
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28 November 2018
AbetaPP induces cdk5-dependent tau hyperphosphorylation in transgenic mice Tg2576.
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28 November 2018
Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029867
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28 November 2018
Interleukin-18 expression after focal ischemia of the rat brain: association with the late-stage inflammatory response.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029867
retrieved
28 November 2018
Neutrophil proteinase 3-mediated induction of bioactive IL-18 secretion by human oral epithelial cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029867
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28 November 2018
In-vivo measurement of activated microglia in dementia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029867
retrieved
28 November 2018
Fatty acid uptake and incorporation in brain: studies with the perfusion model
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029867
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28 November 2018
Cultures of astrocytes and microglia express interleukin 18.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029867
retrieved
28 November 2018
Annual review prize lecture cytokines - killers in the brain?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029867
retrieved
28 November 2018
Cloning of rat brain interleukin-18 cDNA.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029867
retrieved
28 November 2018
Interleukin-1 beta and interleukin-6 are elevated in the cerebrospinal fluid of Alzheimer's and de novo Parkinson's disease patients.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4029867
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28 November 2018
In vivo incorporation of exogenous [1-14C]stearic acid into neurons and astrocytes
1 reference
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PubMed
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https://pubmed.ncbi.nlm.nih.gov/24561250
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Inflammation and Alzheimer's disease
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24561250
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Astrocytes produce and release interleukin-1, interleukin-6, tumor necrosis factor alpha and interferon-gamma following traumatic and metabolic injury
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24561250
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24561250
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Microglia: Intrinsic immuneffector cell of the brain
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24561250
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Interleukin-1 gene (IL1) assigned to long arm of human chromosome 2
1 reference
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PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24561250
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Effects of dietary fat on food intake and brain uptake and oxidation of fatty acids
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24561250
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12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Interleukin-1 as a pathogenetic mediator of ischemic brain damage in rats
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24561250
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Interleukin-18 induces human cardiac endothelial cell death via a novel signaling pathway involving NF-kappaB-dependent PTEN activation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24561250
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Interleukin-18 and transforming growth factor-beta 1 plasma levels in Alzheimer's disease and vascular dementia
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/24561250
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.ARR.2013.12.007
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2271885
Fatcat ID
release_v4mti7rnrzgbnjfkmtm3vj5mhy
1 reference
stated in
Fatcat
reference URL
https://api.fatcat.wiki/v0/release/v4mti7rnrzgbnjfkmtm3vj5mhy
retrieved
24 November 2022
based on heuristic
mapped directly with Wikidata item
OpenCitations bibliographic resource ID
2271885
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2271885
PMCID
4029867
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2271885
PubMed ID
24561250
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
2271885
ResearchGate publication ID
260374354
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