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Regulation of the Epigenome by Vitamin C
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title
Regulation of the Epigenome by Vitamin C
(English)
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main subject
vitamin
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vitamin C
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author
Stephan Züchner
series ordinal
2
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author name string
Juan I. Young
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1
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Crossref
Gaofeng Wang
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3
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language of work or name
English
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publication date
2015
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published in
Annual Review of Nutrition
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PubMed
volume
35
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PubMed
page(s)
545-64
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PubMed
cites work
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Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites
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Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain
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Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphoma
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Genetic variation in the sodium-dependent vitamin C transporters, SLC23A1, and SLC23A2 and risk for preterm delivery
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Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells
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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
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10th NTES Conference: Nickel and Arsenic Compounds Alter the Epigenome of Peripheral Blood Mononuclear Cells
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Vitamin C and survival among women with breast cancer: a meta-analysis
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28 September 2017
Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells
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Ascorbic acid and sodium-dependent vitamin C transporters in the peripheral nervous system: from basic science to clinical trials
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Ascorbate induces ten-eleven translocation (Tet) methylcytosine dioxygenase-mediated generation of 5-hydroxymethylcytosine
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Breathing-in epigenetic change with vitamin C.
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Quantification of 5-methylcytosine and 5-hydroxymethylcytosine in genomic DNA from hepatocellular carcinoma tissues by capillary hydrophilic-interaction liquid chromatography/quadrupole TOF mass spectrometry.
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Vitamin C promotes maturation of T-cells
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Decreased 5-hydroxymethylcytosine is associated with neural progenitor phenotype in normal brain and shorter survival in malignant glioma
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Nuclear exclusion of TET1 is associated with loss of 5-hydroxymethylcytosine in IDH1 wild-type gliomas
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28 September 2017
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation
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28 September 2017
Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells
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TET2 mutations are associated with specific 5-methylcytosine and 5-hydroxymethylcytosine profiles in patients with chronic myelomonocytic leukemia
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Loss of 5-hydroxymethylcytosine is accompanied with malignant cellular transformation
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28 September 2017
5-Hydroxymethylcytosine is strongly depleted in human cancers but its levels do not correlate with IDH1 mutations
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28 September 2017
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28 September 2017
The SLC23 family of ascorbate transporters: ensuring that you get and keep your daily dose of vitamin C
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28 September 2017
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28 September 2017
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28 September 2017
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28 September 2017
Genetic variation at the SLC23A1 locus is associated with circulating concentrations of L-ascorbic acid (vitamin C): evidence from 5 independent studies with >15,000 participants
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28 September 2017
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28 September 2017
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31 May 2018
Vitamin C modulates TET1 function during somatic cell reprogramming
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31 May 2018
Ascorbate-induced generation of 5-hydroxymethylcytosine is unaffected by varying levels of iron and 2-oxoglutarate
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31 May 2018
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31 May 2018
The histone demethylases Jhdm1a/1b enhance somatic cell reprogramming in a vitamin-C-dependent manner.
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31 May 2018
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31 May 2018
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31 May 2018
The effect of periconceptional supplementation on blood vitamin concentrations in women at recurrence risk for neural tube defect
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506708
retrieved
31 May 2018
Ascorbic acid enhances Tet-mediated 5-methylcytosine oxidation and promotes DNA demethylation in mammals
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506708
retrieved
28 November 2018
Succinate dehydrogenase deficiency is associated with decreased 5-hydroxymethylcytosine production in gastrointestinal stromal tumors: implications for mechanisms of tumorigenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506708
retrieved
28 November 2018
Transferrin iron uptake is stimulated by ascorbate via an intracellular reductive mechanism.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506708
retrieved
28 November 2018
Efficient generation of induced pluripotent stem cells from human bone marrow mesenchymal stem cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506708
retrieved
28 November 2018
Two routes of iron accumulation in astrocytes: ascorbate-dependent ferrous iron uptake via the divalent metal transporter (DMT1) plus an independent route for ferric iron.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506708
retrieved
28 November 2018
Serum vitamin C and the prevalence of vitamin C deficiency in the United States: 2003–2004 National Health and Nutrition Examination Survey (NHANES)
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506708
retrieved
28 November 2018
Sodium-dependent vitamin C transporter 2 (SVCT2) is necessary for the uptake of L-ascorbic acid into Schwann cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506708
retrieved
28 November 2018
Ascorbic acid for Charcot-Marie-Tooth disease type 1A in children: a randomised, double-blind, placebo-controlled, safety and efficacy trial.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506708
retrieved
28 November 2018
Non-transferrin iron reduction and uptake are regulated by transmembrane ascorbate cycling in K562 cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506708
retrieved
28 November 2018
TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23).
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506708
retrieved
28 November 2018
Age-related decline of sodium-dependent ascorbic acid transport in isolated rat hepatocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506708
retrieved
28 November 2018
Differential compartmentalization of brain ascorbate and glutathione between neurons and glia
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4506708
retrieved
28 November 2018
Increased facilitated transport of dehydroascorbic acid without changes in sodium-dependent ascorbate transport in human melanoma cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25974700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Evaluation of an acidic deproteinization for the measurement of ascorbate and dehydroascorbate in plasma samples
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25974700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Juvenile and adult olfactory ensheathing cells bundle and myelinate dorsal root ganglion axons in culture
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25974700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Synthesis and effects of basement membrane components in cultured rat Schwann cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25974700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Requisites for growth and myelination of urodele sensory neurons in tissue culture
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25974700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Sodium-dependent vitamin C transporter 2 deficiency causes hypomyelination and extracellular matrix defects in the peripheral nervous system
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25974700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
The non-oxidative degradation of ascorbic acid at physiological conditions
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25974700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Femoral neuropathy in scurvy
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/25974700
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1146/ANNUREV-NUTR-071714-034228
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1028296
OpenCitations bibliographic resource ID
1028296
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1028296
PMC publication ID
4506708
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1028296
PubMed publication ID
25974700
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
1028296
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