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ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling
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PubMed
title
ILK: a pseudokinase in the center stage of cell-matrix adhesion and signaling
(English)
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main subject
cell biology
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author name string
Jun Qin
series ordinal
1
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stated in
Crossref
Chuanyue Wu
series ordinal
2
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stated in
Crossref
language of work or name
English
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stated in
PubMed
publication date
October 2012
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stated in
PubMed
published in
Current Opinion in Cell Biology
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stated in
PubMed
volume
24
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stated in
PubMed
page(s)
607-13
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PubMed
issue
5
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PubMed
cites work
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EphA1 interacts with integrin-linked kinase and regulates cell morphology and motility
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Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase
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The structural basis of integrin-linked kinase-PINCH interactions
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21 March 2017
Integrin-linked kinase localizes to the centrosome and regulates mitotic spindle organization
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Structure of an ultraweak protein-protein complex and its crucial role in regulation of cell morphology and motility
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The protein kinase complement of the human genome
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21 March 2017
Assembly of the PINCH-ILK-CH-ILKBP complex precedes and is essential for localization of each component to cell-matrix adhesion sites
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21 March 2017
A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate interaction
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21 March 2017
A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading
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21 March 2017
Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily
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21 March 2017
The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells
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21 March 2017
Regulation of cell adhesion and anchorage-dependent growth by a new beta 1-integrin-linked protein kinase
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21 March 2017
The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions
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PubMed Central
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21 March 2017
Structural Analysis of the Interactions Between Paxillin LD Motifs and α-Parvin
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21 March 2017
The Structure of -Parvin CH2-Paxillin LD1 Complex Reveals a Novel Modular Recognition for Focal Adhesion Assembly
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21 March 2017
PINCH-1 Is an Obligate Partner of Integrin-linked Kinase (ILK) Functioning in Cell Shape Modulation, Motility, and Survival
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21 March 2017
Integrin signalling adaptors: not only figurants in the cancer story
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21 March 2017
Integrin-linked kinase is an adaptor with essential functions during mouse development
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PubMed Central
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21 March 2017
Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase
1 reference
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PubMed Central
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21 March 2017
Integrin-linked kinase is a functional Mn2+-dependent protein kinase that regulates glycogen synthase kinase-3β (GSK-3beta) phosphorylation
1 reference
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PubMed Central
reference URL
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21 March 2017
Alpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling
1 reference
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PubMed Central
reference URL
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21 March 2017
Targeted ablation of PINCH1 and PINCH2 from murine myocardium results in dilated cardiomyopathy and early postnatal lethality
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PubMed Central
reference URL
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21 March 2017
PINCH1 regulates cell-matrix and cell-cell adhesions, cell polarity and cell survival during the peri-implantation stage
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PubMed Central
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21 March 2017
PINCH1 plays an essential role in early murine embryonic development but is dispensable in ventricular cardiomyocytes
1 reference
stated in
PubMed Central
reference URL
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21 March 2017
Integrin-linked kinase (ILK) is required for polarizing the epiblast, cell adhesion, and controlling actin accumulation
1 reference
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PubMed Central
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21 March 2017
LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration.
1 reference
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PubMed Central
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28 September 2017
Significance of thymosin β4 and implication of PINCH-1-ILK-α-parvin (PIP) complex in human dilated cardiomyopathy
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PubMed Central
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28 September 2017
Integrin-linked kinase: not so 'pseudo' after all.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
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28 September 2017
How integrins control mammary epithelial differentiation: a possible role for the ILK-PINCH-Parvin complex
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
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28 September 2017
Biochemical, proteomic, structural, and thermodynamic characterizations of integrin-linked kinase (ILK): cross-validation of the pseudokinase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
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28 September 2017
A central multifunctional role of integrin-linked kinase at muscle attachment sites.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 September 2017
Pseudokinases-remnants of evolution or key allosteric regulators?
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
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28 September 2017
A critical role of integrin-linked kinase, ch-TOG and TACC3 in centrosome clustering in cancer cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 September 2017
PINCH1 regulates Akt1 activation and enhances radioresistance by inhibiting PP1alpha
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
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28 September 2017
The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase!
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 September 2017
Enhanced liver regeneration following changes induced by hepatocyte-specific genetic ablation of integrin-linked kinase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
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28 September 2017
Mechanisms that regulate adaptor binding to beta-integrin cytoplasmic tails
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 September 2017
Liver-specific ablation of integrin-linked kinase in mice results in abnormal histology, enhanced cell proliferation, and hepatomegaly
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
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28 September 2017
Integrin-linked kinase--essential roles in physiology and cancer biology.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 September 2017
Two LIM domain proteins and UNC-96 link UNC-97/pinch to myosin thick filaments in Caenorhabditis elegans muscle
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 September 2017
Emerging roles of pseudokinases
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 September 2017
PINCH, N(i)ck and the ILK: network wiring at cell-matrix adhesions
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 September 2017
The integrin effector PINCH regulates JNK activity and epithelial migration in concert with Ras suppressor 1.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 September 2017
Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 September 2017
The PINCH-ILK-parvin complexes: assembly, functions and regulation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 September 2017
Caenorhabditis elegans UNC-98, a C2H2 Zn finger protein, is a novel partner of UNC-97/PINCH in muscle adhesion complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 September 2017
CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/Akt
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 September 2017
Drosophila integrin-linked kinase is required at sites of integrin adhesion to link the cytoskeleton to the plasma membrane
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 September 2017
Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
31 May 2018
Molecular dissection of the ILK-PINCH-parvin triad reveals a fundamental role for the ILK kinase domain in the late stages of focal-adhesion maturation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
31 May 2018
Targeted ablation of ILK from the murine heart results in dilated cardiomyopathy and spontaneous heart failure
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
31 May 2018
C. elegans PAT-6/actopaxin plays a critical role in the assembly of integrin adhesion complexes in vivo
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
31 May 2018
Functional analysis of parvin and different modes of IPP-complex assembly at integrin sites during Drosophila development.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 November 2018
Induction of membrane circular dorsal ruffles requires co-signalling of integrin-ILK-complex and EGF receptor.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 November 2018
Bacteria hijack integrin-linked kinase to stabilize focal adhesions and block cell detachment.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 November 2018
UNC-97/PINCH is involved in the assembly of integrin cell adhesion complexes in Caenorhabditis elegans body wall muscle.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 November 2018
Crystal structure of the kinase domain of WNK1, a kinase that causes a hereditary form of hypertension
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
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28 November 2018
Analysis of PINCH function inDrosophilademonstrates its requirement in integrin-dependent cellular processes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 November 2018
C. elegans PAT-4/ILK functions as an adaptor protein within integrin adhesion complexes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3467332
retrieved
28 November 2018
Identifiers
DOI
10.1016/J.CEB.2012.06.003
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PMCID
3467332
1 reference
stated in
PubMed
PubMed ID
22763012
1 reference
stated in
PubMed
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