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The biology and mechanism of action of suppressor of cytokine signaling 3
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Europe PubMed Central
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3757090
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22574771%20AND%20SRC:MED&resulttype=core&format=json
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1 February 2020
title
The biology and mechanism of action of suppressor of cytokine signaling 3
(English)
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Europe PubMed Central
PMCID
3757090
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22574771%20AND%20SRC:MED&resulttype=core&format=json
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1 February 2020
author
Jeffrey J Babon
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1
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Europe PubMed Central
PMCID
3757090
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22574771%20AND%20SRC:MED&resulttype=core&format=json
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1 February 2020
Nicos A. Nicola
series ordinal
2
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Europe PubMed Central
PMCID
3757090
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22574771%20AND%20SRC:MED&resulttype=core&format=json
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1 February 2020
author name string
Jeffrey J. Babon
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1
1 reference
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Nicos A. Nicola
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2
1 reference
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Crossref
language of work or name
English
1 reference
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PubMed
publication date
11 May 2012
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Europe PubMed Central
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3757090
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22574771%20AND%20SRC:MED&resulttype=core&format=json
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1 February 2020
published in
Growth Factors Journal
2 references
stated in
PubMed
stated in
Europe PubMed Central
PMCID
3757090
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22574771%20AND%20SRC:MED&resulttype=core&format=json
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1 February 2020
volume
30
2 references
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PubMed
stated in
Europe PubMed Central
PMCID
3757090
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22574771%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
issue
4
2 references
stated in
PubMed
stated in
Europe PubMed Central
PMCID
3757090
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22574771%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
page(s)
207-219
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Europe PubMed Central
PMCID
3757090
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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22574771%20AND%20SRC:MED&resulttype=core&format=json
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1 February 2020
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SOCS-3 inhibits IL-12-induced STAT4 activation by binding through its SH2 domain to the STAT4 docking site in the IL-12 receptor β2 subunit
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Regulation of liver regeneration and hepatocarcinogenesis by suppressor of cytokine signaling 3
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Transfer of suppressor of cytokine signaling 3 by an oncolytic adenovirus induces potential antitumor activities in hepatocellular carcinoma
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28 September 2017
The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo
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SOCS-3 negatively regulates innate and adaptive immune mechanisms in acute IL-1-dependent inflammatory arthritis
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Suppressor of cytokine signaling 3 limits protection of leukemia inhibitory factor receptor signaling against central demyelination
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The structure of SOCS3 reveals the basis of the extended SH2 domain function and identifies an unstructured insertion that regulates stability.
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28 September 2017
Oncostatin M receptor-mediated signal transduction is negatively regulated by SOCS3 through a receptor tyrosine-independent mechanism.
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Methylation silencing of SOCS-3 promotes cell growth and migration by enhancing JAK/STAT and FAK signalings in human hepatocellular carcinoma
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Enhanced leptin sensitivity and attenuation of diet-induced obesity in mice with haploinsufficiency of Socs3.
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SOCS3 regulates the plasticity of gp130 signaling
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SOCS3 negatively regulates IL-6 signaling in vivo
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SOCS3: an essential regulator of LIF receptor signaling in trophoblast giant cell differentiation
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28 September 2017
Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction
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28 September 2017
SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities
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SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc
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28 September 2017
Suppressors of cytokine signaling proteins are differentially expressed in Th1 and Th2 cells: implications for Th cell lineage commitment and maintenance
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28 September 2017
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
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28 September 2017
SH2 domains: from structure to energetics, a dual approach to the study of structure-function relationships
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28 September 2017
SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation
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28 September 2017
Identification of SOCS-3 as a potential mediator of central leptin resistance
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28 September 2017
Signaling by the cytokine receptor superfamily: JAKs and STATs.
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28 September 2017
The JAK/STAT pathway.
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 September 2017
Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
31 May 2018
Absence of suppressor of cytokine signalling 3 reduces self-renewal and promotes differentiation in murine embryonic stem cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
31 May 2018
Negative regulation of gp130 signalling mediated through tyrosine-757 is not dependent on the recruitment of SHP2.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
31 May 2018
Leukemia inhibitory factor inhibits T helper 17 cell differentiation and confers treatment effects of neural progenitor cell therapy in autoimmune disease.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
SOCS3 deletion promotes optic nerve regeneration in vivo.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
Deficient SOCS3 expression in CD4+CD25+FoxP3+ regulatory T cells and SOCS3-mediated suppression of Treg function
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
Suppressor of cytokine signaling 3 regulates CD8 T-cell proliferation by inhibition of interleukins 6 and 27.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
Enhanced leptin sensitivity and improved glucose homeostasis in mice lacking suppressor of cytokine signaling-3 in POMC-expressing cells.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
Trophoblast stem cells rescue placental defect in SOCS3-deficient mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
SOCS3 negatively regulates LIF signaling in neural precursor cells
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
Loss of SOCS3 in the liver promotes fibrosis by enhancing STAT3-mediated TGF-beta1 production.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
The comparative roles of suppressor of cytokine signaling-1 and -3 in the inhibition and desensitization of cytokine signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
The tyrosine 974 within the LIF-R-chain of the gp130/LIF-R heteromeric receptor complex mediates negative regulation of LIF signalling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
SOCS3 is a critical physiological negative regulator of G-CSF signaling and emergency granulopoiesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
SOCS-1, a negative regulator of the JAK/STAT pathway, is silenced by methylation in human hepatocellular carcinoma and shows growth-suppression activity
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3757090
retrieved
28 November 2018
IL-7 Engages Multiple Mechanisms to Overcome Chronic Viral Infection and Limit Organ Pathology
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22574771
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Role of the Cytokine-inducible SH2 Protein CIS in Desensitization of STAT5b Signaling by Continuous Growth Hormone
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22574771
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Differential activation of signal transducer and activator of transcription (STAT)3 and STAT5 and induction of suppressors of cytokine signalling in Th1 and Th2 cells
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/22574771
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.3109/08977194.2012.687375
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3442717
stated in
Europe PubMed Central
PMCID
3757090
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22574771%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
OpenCitations bibliographic resource ID
3442717
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3442717
PMCID
3757090
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3442717
stated in
Europe PubMed Central
PMCID
3757090
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22574771%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
PubMed ID
22574771
2 references
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
3442717
stated in
Europe PubMed Central
PMCID
3757090
reference URL
https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22574771%20AND%20SRC:MED&resulttype=core&format=json
retrieved
1 February 2020
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