(Q27011240)

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22 February 2020

review article

1 reference

title

The diphthamide modification pathway from Saccharomyces cerevisiae--revisited (English)

1 reference

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22 February 2020

main subject

Saccharomyces cerevisiae

0 references

author

Wael Abdel-Fattah

2

1 reference

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22 February 2020

Roland Klassen

3

1 reference

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22 February 2020

Michael J. Stark

4

1 reference

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22 February 2020

author name string

Raffael Schaffrath

1

2 references

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22 February 2020

language of work or name

1 reference

17 November 2014

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25352115%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

published in

Molecular Microbiology

2 references

PubMed

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22 February 2020

volume

94

2 references

PubMed

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22 February 2020

issue

6

2 references

PubMed

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22 February 2020

page(s)

1213-1226

1 reference

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Insights into diphthamide, key diphtheria toxin effector.

22 February 2020

cites work

1 reference

Elongation factors in protein biosynthesis

21 January 2018

1 reference

The 1998 Garrod lecture. Current and future antifungal therapy: new targets for antifungal agents

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Molecular control of the amount, subcellular location, and activity state of translation elongation factor 2 in neurons experiencing stress

21 January 2018

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Elongation factor 2 diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions.

21 January 2018

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Endogenous ADP-ribosylation for eukaryotic elongation factor 2: evidence of two different sites and reactions

21 January 2018

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A chemical genomic screen in Saccharomyces cerevisiae reveals a role for diphthamidation of translation elongation factor 2 in inhibition of protein synthesis by sordarin

21 January 2018

1 reference

The crystal structure of Escherichia coli TdcF, a member of the highly conserved YjgF/YER057c/UK114 family

21 January 2018

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Two Saccharomyces cerevisiae genes which control sensitivity to G1 arrest induced by Kluyveromyces lactis toxin

21 January 2018

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Haploid genetic screens in human cells identify host factors used by pathogens

21 January 2018

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Ovca1 regulates cell proliferation, embryonic development, and tumorigenesis

21 January 2018

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OVCA1: tumor suppressor gene.

21 January 2018

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Diphtheria toxin-resistant mutants of Saccharomyces cerevisiae

21 January 2018

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Mutations in ABO1/ELO2, a subunit of holo-Elongator, increase abscisic acid sensitivity and drought tolerance in Arabidopsis thaliana

21 January 2018

1 reference

Toward a comprehensive atlas of the physical interactome of Saccharomyces cerevisiae

21 January 2018

1 reference

The genetic landscape of a cell

21 January 2018

1 reference

Comparative genomic analysis of the DUF71/COG2102 family predicts roles in diphthamide biosynthesis and B12 salvage

21 January 2018

1 reference

Molecular mechanisms of the cytotoxicity of ADP-ribosylating toxins

21 January 2018

1 reference

Dph3 is an electron donor for Dph1-Dph2 in the first step of eukaryotic diphthamide biosynthesis.

21 January 2018

1 reference

Endogenous ADP-ribosylation of elongation factor 2 in polyoma virus-transformed baby hamster kidney cells

21 January 2018

1 reference

Characterization of the endogenous ADP‐ribosylation of wild‐type and mutant elongation factor 2 in eukaryotic cells

21 January 2018

1 reference

KTI11 and KTI13, Saccharomyces cerevisiae genes controlling sensitivity to G1 arrest induced by Kluyveromyces lactis zymocin

21 January 2018

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Elongator's toxin-target (TOT) function is nuclear localization sequence dependent and suppressed by post-translational modification.

21 January 2018

1 reference

An iron-sulfur cluster domain in Elp3 important for the structural integrity of elongator.

21 January 2018

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Unique modifications of translation elongation factors

21 January 2018

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The diphthamide modification on elongation factor-2 renders mammalian cells resistant to ricin

21 January 2018

1 reference

Genetic identification of factors that modulate ribosomal DNA transcription in Saccharomyces cerevisiae.

21 January 2018

1 reference

An early step in wobble uridine tRNA modification requires the Elongator complex

21 January 2018

1 reference

A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae

21 January 2018

1 reference

Cellular ADP-ribosylation of elongation factor 2.

21 January 2018

1 reference

Zymocin, a composite chitinase and tRNase killer toxin from yeast

21 January 2018

1 reference

Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocase

21 January 2018

1 reference

Crystal structure of ADP-ribosylated ribosomal translocase from Saccharomyces cerevisiae

21 January 2018

1 reference

The life and death of translation elongation factor 2

21 January 2018

1 reference

Cholix toxin, a novel ADP-ribosylating factor from Vibrio cholerae

21 January 2018

1 reference

The nature and character of the transition state for the ADP-ribosyltransferase reaction

21 January 2018

1 reference

MnmA and IscS are required for in vitro 2-thiouridine biosynthesis in Escherichia coli

21 January 2018

1 reference

Global landscape of protein complexes in the yeast Saccharomyces cerevisiae

21 January 2018

1 reference

Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions

21 January 2018

1 reference

Cellular ADP-ribosyltransferase with the same mechanism of action as diphtheria toxin and Pseudomonas toxin A

21 January 2018

1 reference

An improved, bias-reduced probabilistic functional gene network of baker's yeast, Saccharomyces cerevisiae

21 January 2018

1 reference

S-Adenosylmethionine-dependent alkylation reactions: when are radical reactions used?

21 January 2018

1 reference

Dph7 catalyzes a previously unknown demethylation step in diphthamide biosynthesis

21 January 2018

1 reference

Retroviral insertional mutagenesis identifies a small protein required for synthesis of diphthamide, the target of bacterial ADP-ribosylating toxins

21 January 2018

1 reference

Identification of the proteins required for biosynthesis of diphthamide, the target of bacterial ADP-ribosylating toxins on translation elongation factor 2

21 January 2018

1 reference

Dph3, a small protein required for diphthamide biosynthesis, is essential in mouse development

21 January 2018

1 reference

Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development

21 January 2018

1 reference

ADP-ribosylation of translation elongation factor 2 by diphtheria toxin in yeast inhibits translation and cell separation

21 January 2018

1 reference

DPH5, a methyltransferase gene required for diphthamide biosynthesis in Saccharomyces cerevisiae

21 January 2018

1 reference

Elongator function in tRNA wobble uridine modification is conserved between yeast and plants.

21 January 2018

1 reference

Posttranslational modification of elongation factor 2 in diphtheria-toxin-resistant mutants of CHO-K1 cells

21 January 2018

1 reference

In vitro biosynthesis of diphthamide, studied with mutant Chinese hamster ovary cells resistant to diphtheria toxin

21 January 2018

1 reference

Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain

21 January 2018

1 reference

Elongation factors on the ribosome

21 January 2018

1 reference

Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog

21 January 2018

1 reference

Gene trap mutagenesis-based forward genetic approach reveals that the tumor suppressor OVCA1 is a component of the biosynthetic pathway of diphthamide on elongation factor 2.

21 January 2018

1 reference

Antifungal agents: mechanisms of action

21 January 2018

1 reference

Dominant-negative mutant phenotypes and the regulation of translation elongation factor 2 levels in yeast

21 January 2018

1 reference

Translation elongation factor 2 anticodon mimicry domain mutants affect fidelity and diphtheria toxin resistance

21 January 2018

1 reference

21 January 2018

1 reference

The Elongator subunit Elp3 contains a Fe4S4 cluster and binds S-adenosylmethionine

21 January 2018

1 reference

Biochemical and Structural Characterization of a Novel Family of Cystathionine β-Synthase Domain Proteins Fused to a Zn Ribbon-Like Domain

21 January 2018

1 reference

tRNA tKUUU, tQUUG, and tEUUC wobble position modifications fine-tune protein translation by promoting ribosome A-site binding.

21 January 2018

1 reference

Hydrolysis of GTP by elongation factor G drives tRNA movement on the ribosome

21 January 2018

1 reference

A dominant-negative approach that prevents diphthamide formation confers resistance to Pseudomonas exotoxin A and diphtheria toxin

21 January 2018

1 reference

Network of general and specialty J protein chaperones of the yeast cytosol

21 January 2018

1 reference

Decoding the biosynthesis and function of diphthamide, an enigmatic modification of translation elongation factor 2 (EF2)

21 January 2018

1 reference

Archaeal Elp3 catalyzes tRNA wobble uridine modification at C5 via a radical mechanism

21 January 2018

1 reference

Species-specific inhibition of fungal protein synthesis by sordarin: identification of a sordarin-specificity region in eukaryotic elongation factor 2.

21 January 2018

1 reference

Two novel WD40 domain-containing proteins, Ere1 and Ere2, function in the retromer-mediated endosomal recycling pathway.

21 January 2018

1 reference

Crystal structure of Bacillus subtilis YabJ, a purine regulatory protein and member of the highly conserved YjgF family

21 January 2018

1 reference

DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion

21 January 2018

1 reference

Domain movements of elongation factor eEF2 and the eukaryotic 80S ribosome facilitate tRNA translocation

21 January 2018

1 reference

YBR246W is required for the third step of diphthamide biosynthesis

21 January 2018

1 reference

Chemogenomic approach identified yeast YLR143W as diphthamide synthetase

21 January 2018

1 reference

The biosynthesis and biological function of diphthamide

21 January 2018

1 reference

Solution structure of Kti11p from Saccharomyces cerevisiae reveals a novel zinc-binding module.

21 January 2018

1 reference

Structures of modified eEF2 80S ribosome complexes reveal the role of GTP hydrolysis in translocation

21 January 2018

1 reference

Structure and mechanistic insights into novel iron-mediated moonlighting functions of human J-protein cochaperone, Dph4

21 January 2018

1 reference

The amidation step of diphthamide biosynthesis in yeast requires DPH6, a gene identified through mining the DPH1-DPH5 interaction network

21 January 2018

1 reference

Structural basis of the translational elongation cycle

21 January 2018

1 reference

Diphthamide modification of eEF2 requires a J-domain protein and is essential for normal development

21 January 2018

1 reference

A modified form of diphthamide causes immunotoxin resistance in a lymphoma cell line with a deletion of the WDR85 gene

21 January 2018

1 reference

Stealth and mimicry by deadly bacterial toxins

21 January 2018

1 reference

High-quality binary protein interaction map of the yeast interactome network

21 January 2018

1 reference

Role of OVCA1/DPH1 in craniofacial abnormalities of Miller-Dieker syndrome.

21 January 2018

1 reference

Yeast alpha-tubulin suppressor Ats1/Kti13 relates to the Elongator complex and interacts with Elongator partner protein Kti11.

21 January 2018

1 reference

Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme

21 January 2018

1 reference

Reconstitution of diphthine synthase activity in vitro

21 January 2018

1 reference

Mechanistic understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] enzyme required for diphthamide biosynthesis

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1111/MMI.12845

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25352115%20AND%20SRC:MED&resulttype=core&format=json

22 February 2020

1 reference

Consolidated OpenCitations Corpus – April 2017

2 references

Consolidated OpenCitations Corpus – April 2017

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25352115%20AND%20SRC:MED&resulttype=core&format=json