(Q27012589)

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The Allosteric Site for the Nascent Cell Wall in Penicillin-Binding Protein 2a: An Achilles' Heel of Methicillin-Resistant Staphylococcus aureus

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Europe PubMed Central

The Allosteric Site for the Nascent Cell Wall in Penicillin-Binding Protein 2a: An Achilles' Heel of Methicillin-Resistant Staphylococcus aureus (English)

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methicillin-resistant Staphylococcus aureus

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1 reference

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inferred from title

Staphylococcus aureus

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1

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5 June 2020

2

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Mayland Chang

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5 June 2020

Shahriar Mobashery

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object named as

Shahriar Mobashery

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5 June 2020

author name string

Juan A Hermoso

4

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2015

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Current Medicinal Chemistry

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5 June 2020

22

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5 June 2020

14

2 references

Europe PubMed Central

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5 June 2020

1678-1686

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Europe PubMed Central

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5 June 2020

Antimicrobial resistance: the example of Staphylococcus aureus

1 reference

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21 March 2017

Electrostatics of nanosystems: application to microtubules and the ribosome

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21 March 2017

Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics

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21 March 2017

How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function

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21 March 2017

Crystal structures of penicillin-binding protein 3 (PBP3) from methicillin-resistant Staphylococcus aureus in the apo and cefotaxime-bound forms

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Structural Insights into the Anti-methicillin-resistant Staphylococcus aureus (MRSA) Activity of Ceftobiprole

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21 March 2017

Molecular Basis for the Role of Staphylococcus aureus Penicillin Binding Protein 4 in Antimicrobial Resistance

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21 March 2017

Structural insight into the transglycosylation step of bacterial cell-wall biosynthesis

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21 March 2017

Structural basis for the beta lactam resistance of PBP2a from methicillin-resistant Staphylococcus aureus

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21 March 2017

The crystal structure of the penicillin-binding protein 2x from Streptococcus pneumoniae and its acyl-enzyme form: implication in drug resistance

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21 March 2017

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21 March 2017

Penicillin-binding proteins and beta-lactam resistance

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21 March 2017

Bactericidal agents in the treatment of MRSA infections--the potential role of daptomycin

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7 April 2017

Antimicrobial innovation: combining commitment, creativity and coherence

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28 September 2017

PBP2a mutations causing high-level Ceftaroline resistance in clinical methicillin-resistant Staphylococcus aureus isolates.

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What do we need to do to tackle antimicrobial resistance?

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28 September 2017

Methicillin-resistant Staphylococcus aureus: an evolving pathogen

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28 September 2017

Bacterial cell-wall recycling.

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28 September 2017

Ceftaroline in complicated skin and skin-structure infections

1 reference

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28 September 2017

Allostery and the Monod-Wyman-Changeux model after 50 years

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Identification of allosteric-activating drug leads for human liver pyruvate kinase

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Exploring the binding sites of glycogen synthase kinase 3. Identification and characterization of allosteric modulation cavities.

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28 September 2017

Ceftaroline: A New Cephalosporin with Activity against Methicillin-Resistant Staphylococcus aureus (MRSA)

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28 September 2017

Allosteric receptors: from electric organ to cognition

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28 September 2017

Allosteric regulation and catalysis emerge via a common route.

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Taxol allosterically alters the dynamics of the tubulin dimer and increases the flexibility of microtubules

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28 September 2017

Co-opting the cell wall in fighting methicillin-resistant Staphylococcus aureus: potent inhibition of PBP 2a by two anti-MRSA beta-lactam antibiotics

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28 September 2017

The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis

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28 September 2017

Penicillin binding proteins: key players in bacterial cell cycle and drug resistance processes.

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Biochemistry and comparative genomics of SxxK superfamily acyltransferases offer a clue to the mycobacterial paradox: presence of penicillin-susceptible target proteins versus lack of efficiency of penicillin as therapeutic agent

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28 September 2017

Complementation of the essential peptidoglycan transpeptidase function of penicillin-binding protein 2 (PBP2) by the drug resistance protein PBP2A in Staphylococcus aureus

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Cloning, characterization, and inactivation of the gene pbpC, encoding penicillin-binding protein 3 of Staphylococcus aureus

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Site-directed mutagenesis of the mecA gene from a methicillin-resistant strain of Staphylococcus aureus

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Active-site-serine D-alanyl-D-alanine-cleaving-peptidase-catalysed acyl-transfer reactions. Procedures for studying the penicillin-binding proteins of bacterial plasma membranes

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31 May 2018

Activation for catalysis of penicillin-binding protein 2a from methicillin-resistant Staphylococcus aureus by bacterial cell wall

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Structure of Hæmoglobin : An X-ray Examination of Reduced Horse Hæmoglobin

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10.2174/0929867322666150311150215

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Europe PubMed Central

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5 June 2020

2 references

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5 June 2020

2 references

Europe PubMed Central

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5 June 2020

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