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Systems genetics for drug target discovery
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title
Systems genetics for drug target discovery
(English)
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author
Jason H. Moore
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Jason H. Moore
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3
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author name string
Nadia M. Penrod
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1
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Richard Cowper-Sal-lari
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2
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language of work or name
English
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publication date
October 2011
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PubMed
published in
Trends in Pharmacological Sciences
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PubMed
volume
32
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PubMed
issue
10
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PubMed
page(s)
623-30
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PubMed
cites work
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21 March 2017
Identifying druggable disease-modifying gene products
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21 March 2017
Potential etiologic and functional implications of genome-wide association loci for human diseases and traits
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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
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21 March 2017
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PubMed Central
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PubMed Central
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Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
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The Sequence of the Human Genome
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Network biology: understanding the cell's functional organization
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21 March 2017
The structure of haplotype blocks in the human genome
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Integrated functional, gene expression and genomic analysis for the identification of cancer targets
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PubMed Central
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Histone modifications at human enhancers reflect global cell-type-specific gene expression
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PubMed Central
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Network pharmacology: the next paradigm in drug discovery
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PubMed Central
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How many drug targets are there?
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185183
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Complement factor H variant increases the risk of age-related macular degeneration
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PubMed Central
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Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
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Common SNPs explain a large proportion of the heritability for human height
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PubMed Central
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Missing heritability and strategies for finding the underlying causes of complex disease
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PubMed Central
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PubMed Central
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1 reference
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PubMed Central
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Replicating genotype-phenotype associations
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PubMed Central
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7 April 2017
Complement factor H polymorphism and age-related macular degeneration
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185183
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Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome
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7 April 2017
Genetics. Systems genetics.
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PubMed Central
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PubMed Central
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Systems biology and genomics of breast cancer
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PubMed Central
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28 September 2017
Complement, age-related macular degeneration and a vision of the future
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185183
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Bioinformatics challenges for genome-wide association studies
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PubMed Central
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Detecting gene-gene interactions that underlie human diseases
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PubMed Central
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Dynamic proteomics of individual cancer cells in response to a drug.
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PubMed Central
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28 September 2017
Genome-wide association studies: progress and potential for drug discovery and development
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PubMed Central
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PubMed Central
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Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
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PubMed Central
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Mapping networks of physical interactions between genomic elements using 5C technology
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Functional genomics to new drug targets
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185183
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28 September 2017
Systems biology in drug discovery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185183
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28 September 2017
Chromosome studies on normal and leukemic human leukocytes
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185183
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28 September 2017
Distinctive gene expression patterns in human mammary epithelial cells and breast cancers
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185183
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28 September 2017
Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative.
1 reference
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PubMed Central
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28 September 2017
An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity.
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185183
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28 September 2017
Reciprocal translocation and the Philadelphia chromosome
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185183
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28 September 2017
Progress and challenges in genome-wide association studies in humans
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PubMed Central
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31 May 2018
The chronic myelogenous leukemia-specific P210 protein is the product of the bcr/abl hybrid gene
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185183
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31 May 2018
Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185183
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31 May 2018
Acute leukaemia in bcr/abl transgenic mice
1 reference
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PubMed Central
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31 May 2018
Competitiveness in follow-on drug R&D: a race or imitation?
1 reference
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PubMed Central
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28 November 2018
Identification of information flow-modulating drug targets: a novel bridging paradigm for drug discovery
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185183
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28 November 2018
A robustness-based approach to systems-oriented drug design.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185183
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28 November 2018
Multiple weak hits confuse complex systems: a transcriptional regulatory network as an example.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3185183
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28 November 2018
Identifiers
DOI
10.1016/J.TIPS.2011.07.002
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
339319
OpenCitations bibliographic resource ID
339319
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
339319
PMC publication ID
3185183
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
339319
PubMed publication ID
21862141
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
339319
ResearchGate publication ID
51590768
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