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NEDD4: a promising target for cancer therapy
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PubMed
title
NEDD4: a promising target for cancer therapy
(English)
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author name string
Ye X
series ordinal
1
1 reference
stated in
PubMed
Wang L
series ordinal
2
1 reference
stated in
PubMed
Shang B
series ordinal
3
1 reference
stated in
PubMed
Wang Z
series ordinal
4
1 reference
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Wei W
series ordinal
5
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language of work or name
English
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publication date
2014
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published in
Current Cancer Drug Targets
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PubMed
volume
14
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stated in
PubMed
page(s)
549-56
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PubMed
issue
6
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PubMed
cites work
SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway
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Ubiquitin-dependent regulation of phospho-AKT dynamics by the ubiquitin E3 ligase, NEDD4-1, in the insulin-like growth factor-1 response
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Upregulation of the E3 ligase NEDD4-1 by oxidative stress degrades IGF-1 receptor protein in neurodegeneration
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21 March 2017
Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development
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21 March 2017
Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions
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Abnormal development of the neuromuscular junction in Nedd4-deficient mice
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21 March 2017
Nedd4 controls animal growth by regulating IGF-1 signaling
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PubMed Central
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21 March 2017
Nedd4 mediates agonist-dependent ubiquitination, lysosomal targeting, and degradation of the beta2-adrenergic receptor
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PubMed Central
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21 March 2017
Deregulated proteolysis by the F-box proteins SKP2 and beta-TrCP: tipping the scales of cancer
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PubMed Central
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21 March 2017
NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN
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PubMed Central
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21 March 2017
Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation
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PubMed Central
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The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor
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21 March 2017
WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome
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PubMed Central
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21 March 2017
Caspase-mediated cleavage of the ubiquitin-protein ligase Nedd4 during apoptosis
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PubMed Central
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21 March 2017
The ubiquitin ligase Nedd4-1 is required for heart development and is a suppressor of thrombospondin-1
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PubMed Central
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21 March 2017
Physiological functions of the HECT family of ubiquitin ligases
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7 April 2017
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28 September 2017
The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells.
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28 September 2017
Regulation of Mdm2 protein stability and the p53 response by NEDD4-1 E3 ligase
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PubMed Central
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28 September 2017
The regulation of MDM2 oncogene and its impact on human cancers
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28 September 2017
NEDD4L is downregulated in colorectal cancer and inhibits canonical WNT signaling
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PubMed Central
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28 September 2017
Targeting MDM2-p53 interaction for cancer therapy: are we there yet?
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28 September 2017
p34 is a novel regulator of the oncogenic behavior of NEDD4-1 and PTEN.
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PubMed Central
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28 September 2017
Targeted inhibition of VEGF receptor 2: an update on ramucirumab
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PubMed Central
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28 September 2017
IGF-1R as an anti-cancer target--trials and tribulations
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PubMed Central
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28 September 2017
Mammalian HECT ubiquitin-protein ligases: biological and pathophysiological aspects
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PubMed Central
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28 September 2017
Deltex-1 activates mitotic signaling and proliferation and increases the clonogenic and invasive potential of U373 and LN18 glioblastoma cells and correlates with patient survival
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PubMed Central
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28 September 2017
Beclin-1: autophagic regulator and therapeutic target in cancer
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PubMed Central
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28 September 2017
Insulin-like growth factor receptor type I as a target for cancer therapy
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
Nedd4 and Nedd4-2: ubiquitin ligases at work in the neuron.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
Is NEDD4-1 a negative regulator of phosphatase and tensin homolog in gastric carcinogenesis?
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
The ubiquitin ligase Nedd4-1 participates in denervation-induced skeletal muscle atrophy in mice
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 September 2017
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
Regulators of mammalian Hippo pathway in cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
The iron-regulated metastasis suppressor NDRG1 targets NEDD4L, PTEN, and SMAD4 and inhibits the PI3K and Ras signaling pathways
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
Photodynamic therapy leads to death of C6 glioma cells partly through AMPAR.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
Beclin1: a role in membrane dynamics and beyond
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
Glutamate increases pancreatic cancer cell invasion and migration via AMPA receptor activation and Kras-MAPK signaling
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
Activity-dependent ubiquitination of GluA1 mediates a distinct AMPA receptor endocytosis and sorting pathway
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
LATS tumor suppressor: a new governor of cellular homeostasis
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
Oncogenic role of the E3 ubiquitin ligase NEDD4-1, a PTEN negative regulator, in non-small-cell lung carcinomas
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
Protein kinase Cdelta supports survival of MDA-MB-231 breast cancer cells by suppressing the ERK1/2 pathway
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
Systems biology approach to identification of biomarkers for metastatic progression in gastric cancer
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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28 September 2017
Knockdown of ASIC1 and epithelial sodium channel subunits inhibits glioblastoma whole cell current and cell migration.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 September 2017
Targeting the ubiquitin system in cancer therapy
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 September 2017
The cyclin-dependent kinase activator, Spy1A, is targeted for degradation by the ubiquitin ligase NEDD4.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 September 2017
The HECT family of E3 ubiquitin ligases: multiple players in cancer development
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 September 2017
Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 September 2017
The Nedd4-like family of E3 ubiquitin ligases and cancer
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 September 2017
The ring between ring fingers (RBR) protein family
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 September 2017
Ubiquitin and ubiquitin-like proteins in cancer pathogenesis
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 September 2017
Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 September 2017
The kinase Grk2 regulates Nedd4/Nedd4-2-dependent control of epithelial Na+ channels
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 September 2017
WW domain HECT E3s target Cbl RING finger E3s for proteasomal degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 September 2017
NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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31 May 2018
Identification of Nedd4 as a novel regulator in Hedgehog signaling.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
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31 May 2018
The tumour suppressor PTEN mediates a negative regulation of the E3 ubiquitin-protein ligase Nedd4.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
31 May 2018
AKT kinase pathway: a leading target in cancer research.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 November 2018
Subtle gait abnormalities in Nedd4 heterozygous mice.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 November 2018
Oncogenic function of p34SEI-1 via NEDD4‑1‑mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 November 2018
The Spy1/RINGO family represents a novel mechanism regulating mammary growth and tumorigenesis.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 November 2018
Molecular mechanisms of coupled monoubiquitination
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 November 2018
Regulation of notch endosomal sorting and signaling by Drosophila Nedd4 family proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 November 2018
Drosophila Nedd4 regulates endocytosis of notch and suppresses its ligand-independent activation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4302323
retrieved
28 November 2018
Identifiers
DOI
10.2174/1568009614666140725092430
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PMCID
4302323
1 reference
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PubMed
PubMed ID
25088038
1 reference
stated in
PubMed
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