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The HECT family of E3 ubiquitin ligases: multiple players in cancer development

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Europe PubMed Central

18 August 2017

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Europe PubMed Central

title

The HECT family of E3 ubiquitin ligases: multiple players in cancer development (English)

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stated in

Europe PubMed Central

18 August 2017

2

Michael Karin

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stated in

Europe PubMed Central

18 August 2017

3

Aaron Ciechanover

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stated in

Europe PubMed Central

18 August 2017

1

Francesca Bernassola

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stated in

Europe PubMed Central

18 August 2017

Gerry Melino

4

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stated in

Europe PubMed Central

18 August 2017

1 July 2008

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stated in

Europe PubMed Central

18 August 2017

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Europe PubMed Central

18 August 2017

14

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Europe PubMed Central

18 August 2017

10-21

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Europe PubMed Central

18 August 2017

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Europe PubMed Central

18 August 2017

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

1 reference

24 May 2022

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NEDD4-1 is a proto-oncogenic ubiquitin ligase for PTEN

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The proteasome and proteasome inhibitors in cancer therapy

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ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor

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Mule/ARF-BP1, a BH3-only E3 ubiquitin ligase, catalyzes the polyubiquitination of Mcl-1 and regulates apoptosis

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A single motif responsible for ubiquitin recognition and monoubiquitination in endocytic proteins

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Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Chemosensitivity linked to p73 function

1 reference

11 October 2022

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Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Essential role for nuclear PTEN in maintaining chromosomal integrity

1 reference

11 October 2022

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Ubiquitination regulates PTEN nuclear import and tumor suppression

1 reference

11 October 2022

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The HECT domain ligase itch ubiquitinates endophilin and localizes to the trans-Golgi network and endosomal system

1 reference

11 October 2022

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The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation

1 reference

11 October 2022

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Cdc6 stability is regulated by the Huwe1 ubiquitin ligase after DNA damage

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

The amplified WWP1 gene is a potential molecular target in breast cancer

1 reference

11 October 2022

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TAK1 is a ubiquitin-dependent kinase of MKK and IKK

1 reference

11 October 2022

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Tumor predisposition in mice mutant for p63 and p73: evidence for broader tumor suppressor functions for the p53 family

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

The ins and outs of MYC regulation by posttranslational mechanisms

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

The itchy locus encodes a novel ubiquitin protein ligase that is disrupted in a18H mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Regulation of p53 localization and transcription by the HECT domain E3 ligase WWP1

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1

1 reference

11 October 2022

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Mass spectrometric and mutational analyses reveal Lys-6-linked polyubiquitin chains catalyzed by BRCA1-BARD1 ubiquitin ligase

1 reference

11 October 2022

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TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Ligand-independent degradation of epidermal growth factor receptor involves receptor ubiquitylation and Hgs, an adaptor whose ubiquitin-interacting motif targets ubiquitylation by Nedd4.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Conformational flexibility underlies ubiquitin ligation mediated by the WWP1 HECT domain E3 ligase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

The C2 domain of the Rsp5 ubiquitin ligase binds membrane phosphoinositides and directs ubiquitination of endosomal cargo

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Regulation of Smurf2 ubiquitin ligase activity by anchoring the E2 to the HECT domain

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Basic mechanisms of high-risk human papillomavirus-induced carcinogenesis: roles of E6 and E7 proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Loss of p63 expression is associated with tumor progression in bladder cancer

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Alzheimer disease-specific conformation of hyperphosphorylated paired helical filament-Tau is polyubiquitinated through Lys-48, Lys-11, and Lys-6 ubiquitin conjugation.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Formation and nuclear export of tRNA, rRNA and mRNA is regulated by the ubiquitin ligase Rsp5p

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Intracellular protein degradation: from a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Mammalian numb proteins promote Notch1 receptor ubiquitination and degradation of the Notch1 intracellular domain

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Itch/AIP4 mediates Deltex degradation through the formation of K29-linked polyubiquitin chains

1 reference

11 October 2022

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Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase

1 reference

11 October 2022

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Proteasome-independent functions of ubiquitin in endocytosis and signaling

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Global changes to the ubiquitin system in Huntington's disease.

1 reference

11 October 2022

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Notch and cancer: best to avoid the ups and downs.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

When ubiquitin meets ubiquitin receptors: a signalling connection

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Itch inhibition regulates chemosensitivity in vitro

1 reference

11 October 2022

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HECT E3s and human disease

1 reference

11 October 2022

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N4WBP5A (Ndfip2), a Nedd4-interacting protein, localizes to multivesicular bodies and the Golgi, and has a potential role in protein trafficking

1 reference

11 October 2022

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Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability

1 reference

11 October 2022

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Characterization of Human hect Domain Family Members and Their Interaction with UbcH5 and UbcH7

1 reference

11 October 2022

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The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Ubiquitin-dependent degradation of p73 is inhibited by PML.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Small molecule inhibitors of HDM2 ubiquitin ligase activity stabilize and activate p53 in cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Dual regulation of c-Myc by p300 via acetylation-dependent control of Myc protein turnover and coactivation of Myc-induced transcription.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Fatal outcome of a hypersensitivity reaction to paclitaxel: a critical review of premedication regimens

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

The ubiquitin-proteasome proteolytic pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

E3-independent monoubiquitination of ubiquitin-binding proteins.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Ubiquitin E3 ligase WWP1 as an oncogenic factor in human prostate cancer

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Interaction between two ubiquitin-protein isopeptide ligases of different classes, CBLC and AIP4/ITCH.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Multiple monoubiquitination of RTKs is sufficient for their endocytosis and degradation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

The ubiquitin-protein ligase Itch regulates p73 stability

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

p73: Friend or foe in tumorigenesis

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

All three WW domains of murine Nedd4 are involved in the regulation of epithelial sodium channels by intracellular Na+

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

The mRNA nuclear export factor Hpr1 is regulated by Rsp5-mediated ubiquitylation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

HECT ubiquitin ligases link viral and cellular PPXY motifs to the vacuolar protein-sorting pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Notch1 functions as a tumor suppressor in mouse skin

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

The HECT ubiquitin ligase AIP4 regulates the cell surface expression of select TRP channels

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Functional regulation of p73 and p63: development and cancer

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Autoinhibition of the HECT-type ubiquitin ligase Smurf2 through its C2 domain

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Recognition and ubiquitination of Notch by Itch, a hect-type E3 ubiquitin ligase

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Over-expression of human UREB1 in colorectal cancer: HECT domain of human UREB1 inhibits the activity of tumor suppressor p53 protein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Identification of HHR23A as a substrate for E6-associated protein-mediated ubiquitination.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

The role of E6AP in the regulation of p53 protein levels in human papillomavirus (HPV)-positive and HPV-negative cells.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Identification of a human ubiquitin-conjugating enzyme that mediates the E6-AP-dependent ubiquitination of p53

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

A possible tumor suppressor role of the KLF5 transcription factor in human breast cancer

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

TAp63alpha induces apoptosis by activating signaling via death receptors and mitochondria

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Expression of Smad4 and Smad7 in human thyroid follicular carcinoma cell lines.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Regulation of the Drosophila ubiquitin ligase DIAP1 is mediated via several distinct ubiquitin system pathways.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Stimulation of c-MYC transcriptional activity and acetylation by recruitment of the cofactor CBP.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Comparative analysis of p73 and p53 regulation and effector functions

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

The E3 ubiquitin ligase AIP4 mediates ubiquitination and sorting of the G protein-coupled receptor CXCR4

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Regulation of functional diversity within the Nedd4 family by accessory and adaptor proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Human Kruppel-like factor 5 is a target of the E3 ubiquitin ligase WWP1 for proteolysis in epithelial cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Overexpression of the TGF-beta antagonist Smad7 in endometrial cancer

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

The E3 ubiquitin ligase Itch controls the protein stability of p63

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

The ubiquitin system for protein degradation and some of its roles in the control of the cell division cycle

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

The E6AP ubiquitin ligase is required for transactivation of the hTERT promoter by the human papillomavirus E6 oncoprotein.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.CCR.2008.06.001

Identifiers

DOI

10.1016/J.CCR.2008.06.001

1 reference

stated in

Europe PubMed Central

18 August 2017

1 reference

Europe PubMed Central

PubMed ID

18598940

retrieved

18 August 2017

ResearchGate publication ID

5254329

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(Q37206488)

The HECT family of E3 ubiquitin ligases: multiple players in cancer development

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