(Q40437388)

20 September 2017

Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases (English)

1 reference

20 September 2017

Anita Morén

1

1 reference

20 September 2017

Takeshi Imamura

2

1 reference

20 September 2017

Kohei Miyazono

3

1 reference

20 September 2017

Carl-Henrik Heldin

4

1 reference

20 September 2017

Aristidis Moustakas

5

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20 September 2017

language of work or name

English

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publication date

6 April 2005

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Journal of Biological Chemistry

20 September 2017

9

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based on heuristic

inferred from page(s)

published in

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20 September 2017

280

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20 September 2017

22115-22123

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20 September 2017

23

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Smad-dependent and Smad-independent pathways in TGF-beta family signalling

20 September 2017

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Regulation of TGF-beta signaling and its roles in progression of tumors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

CHIP mediates degradation of Smad proteins and potentially regulates Smad-induced transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Copper-inducible transcription: regulation by metal- and oxidative stress-responsive pathways

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2-induced osteoblast conversion by targeting Smad5 for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Smurf1 inhibits osteoblast differentiation and bone formation in vitro and in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

NEDD4-2 (neural precursor cell expressed, developmentally down-regulated 4-2) negatively regulates TGF-beta (transforming growth factor-beta) signalling by inducing ubiquitin-mediated degradation of Smad2 and TGF-beta type I receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

dSmurf Selectively Degrades Decapentaplegic-activated MAD, and Its Overexpression Disrupts Imaginal Disc Development

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Smad4 protein stability is regulated by ubiquitin ligase SCF beta-TrCP1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Sumoylation of Smad4, the Common Smad Mediator of Transforming Growth Factor-β Family Signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Regulation of Smad4 sumoylation and transforming growth factor-beta signaling by protein inhibitor of activated STAT1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Activation of transforming growth factor-beta signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Repression of Smad4 transcriptional activity by SUMO modification

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Transforming Growth Factor-β-mediated Signaling via the p38 MAP Kinase Pathway Activates Smad-dependent Transcription through SUMO-1 Modification of Smad4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Highwire regulates presynaptic BMP signaling essential for synaptic growth.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Ubiquitination and proteolysis of cancer-derived Smad4 mutants by SCFSkp2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Negative regulation of transforming growth factor-beta (TGF-beta) signaling by WW domain-containing protein 1 (WWP1)

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Control of Smad7 stability by competition between acetylation and ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Jab1/CSN5, a component of the COP9 signalosome, regulates transforming growth factor beta signaling by binding to Smad7 and promoting its degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Arkadia amplifies TGF-beta superfamily signalling through degradation of Smad7

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Nuclear factor YY1 inhibits transforming growth factor beta- and bone morphogenetic protein-induced cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Smad6 inhibits signalling by the TGF-beta superfamily.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Structural basis of heteromeric smad protein assembly in TGF-beta signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

In or out? The dynamics of Smad nucleocytoplasmic shuttling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

New insights into TGF-beta-Smad signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Regulation of cell polarity and protrusion formation by targeting RhoA for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Crystal Structure of a Phosphorylated Smad2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

A structural basis for mutational inactivation of the tumour suppressor Smad4

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M414027200

21 January 2018

Identifiers

DOI

10.1074/JBC.M414027200

1 reference

20 September 2017

1 reference