(Q27025974)

English

GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists

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scholarly article

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1 March 2020

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12 August 2020

21 September 2020

GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists (English)

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1 March 2020

cell surface receptor

1 reference

31 July 2019

mental depression

7 references

31 July 2019

2 October 2019

20 November 2019

28 November 2019

15 December 2019

12 August 2020

21 September 2020

mechanism of action

1 reference

2 October 2019

1 reference

20 November 2019

transport protein

1 reference

28 November 2019

membrane protein

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15 December 2019

excitatory amino acid receptor agonist

1 reference

12 August 2020

1 reference

21 September 2020

John F. Disterhoft

6

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1 March 2020

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Joseph R Moskal

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1 March 2020

Ronald Burch

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1 March 2020

Jeffrey S Burgdorf

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1 March 2020

Roger A Kroes

4

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1 March 2020

Patric K Stanton

5

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1 March 2020

J David Leander

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1 February 2014

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12 August 2020

21 September 2020

Expert Opinion on Investigational Drugs

9 references

31 July 2019

2 October 2019

20 November 2019

28 November 2019

15 December 2019

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1 March 2020

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1 March 2020

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1 March 2020

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1 reference

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1 reference

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The N-methyl-D-aspartate receptor modulator GLYX-13 enhances learning and memory, in young adult and learning impaired aging rats

1 reference

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21 March 2017

1 reference

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A rating scale for depression

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A modification of receptor theory

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D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor

1 reference

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An Inventory for Measuring Depression

1 reference

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Evaluation of the phencyclidine-like discriminative stimulus effects of novel NMDA channel blockers in rats

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Glutamate receptor ion channels: structure, regulation, and function

1 reference

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Changing subunit composition of heteromeric NMDA receptors during development of rat cortex

1 reference

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Functional consequences of reduction in NMDA receptor glycine affinity in mice carrying targeted point mutations in the glycine binding site

1 reference

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21 March 2017

Cloning, expression and modulation of a mouse NMDA receptor subunit

1 reference

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21 March 2017

Functional characterization of a heteromeric NMDA receptor channel expressed from cloned cDNAs

1 reference

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21 March 2017

Dynamic control of CaMKII translocation and localization in hippocampal neurons by NMDA receptor stimulation

1 reference

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21 March 2017

Developmental and regional expression in the rat brain and functional properties of four NMDA receptors

1 reference

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21 March 2017

mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists

1 reference

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7 April 2017

Learning induces long-term potentiation in the hippocampus

1 reference

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7 April 2017

A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression

1 reference

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7 April 2017

Synaptic plasticity and memory: an evaluation of the hypothesis

1 reference

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7 April 2017

Antidepressant effects of ketamine in depressed patients

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4721220

7 April 2017

NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4721220

28 September 2017

GLYX-13, a NMDA receptor glycine-site functional partial agonist, induces antidepressant-like effects without ketamine-like side effects

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4721220

28 September 2017

Brief environmental enrichment elicits metaplasticity of hippocampal synaptic potentiation in vivo

1 reference

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28 September 2017

A randomized trial of a low-trapping nonselective N-methyl-D-aspartate channel blocker in major depression

1 reference

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28 September 2017

A randomized add-on trial of high-dose D-cycloserine for treatment-resistant depression

1 reference

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28 September 2017

The BCM theory of synapse modification at 30: interaction of theory with experiment

1 reference

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28 September 2017

A pivotal role of GSK-3 in synaptic plasticity.

1 reference

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28 September 2017

Signaling pathways underlying the pathophysiology and treatment of depression: novel mechanisms for rapid-acting agents

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28 September 2017

Compartmentalized versus global synaptic plasticity on dendrites controlled by experience

1 reference

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28 September 2017

The Columbia-Suicide Severity Rating Scale: initial validity and internal consistency findings from three multisite studies with adolescents and adults

1 reference

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28 September 2017

Signaling pathways underlying the rapid antidepressant actions of ketamine

1 reference

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28 September 2017

NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4721220

28 September 2017

Positive emotional learning is regulated in the medial prefrontal cortex by GluN2B-containing NMDA receptors.

1 reference

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28 September 2017

Calmodulin as a direct detector of Ca2+ signals

1 reference

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Making memories last: the synaptic tagging and capture hypothesis

1 reference

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Frequency-modulated 50 kHz ultrasonic vocalizations: a tool for uncovering the molecular substrates of positive affect

1 reference

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Structural determinants of D-cycloserine efficacy at the NR1/NR2C NMDA receptors

1 reference

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A systematic investigation of the protein kinases involved in NMDA receptor-dependent LTD: evidence for a role of GSK-3 but not other serine/threonine kinases

1 reference

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The discriminative stimulus effects of N-methyl-D-aspartate glycine-site ligands in NMDA antagonist-trained rats

1 reference

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An innovative design to establish proof of concept of the antidepressant effects of the NR2B subunit selective N-methyl-D-aspartate antagonist, CP-101,606, in patients with treatment-refractory major depressive disorder.

1 reference

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A NMDA receptor glycine site partial agonist, GLYX-13, simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus

1 reference

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Differential effects of chronic antidepressant treatment on shuttle box escape deficits induced by uncontrollable stress

1 reference

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Learning, aging and intrinsic neuronal plasticity.

1 reference

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Controlled trial of D-cycloserine adjuvant therapy for treatment-resistant major depressive disorder

1 reference

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NMDA receptor subunit composition controls synaptic plasticity by regulating binding to CaMKII.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4721220

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GLYX-13: a monoclonal antibody-derived peptide that acts as an N-methyl-D-aspartate receptor modulator.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4721220

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Recent advances in animal models of chronic antidepressant effects: the novelty-induced hypophagia test

1 reference

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Effects of ketamine and N-methyl-D-aspartate on glutamate and dopamine release in the rat prefrontal cortex: modulation by a group II selective metabotropic glutamate receptor agonist LY379268.

1 reference

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Assessing antidepressant activity in rodents: recent developments and future needs

1 reference

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The use of antibody engineering to create novel drugs that target N-methyl-D-aspartate receptors

1 reference

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1 reference

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Calcium/calmodulin-dependent protein kinase II is associated with the N-methyl-D-aspartate receptor

1 reference

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LTD, LTP, and the sliding threshold for long-term synaptic plasticity

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28 September 2017

Long-term potentiation and N-methyl-D-aspartate receptors: foundations of memory and neurologic disease?

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28 September 2017

Inhibition of the production and maintenance of long-term potentiation in rat hippocampal slices by a monoclonal antibody

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28 September 2017

Glycine-like modulation of N-methyl-D-aspartate receptors by a monoclonal antibody that enhances long-term potentiation

1 reference

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28 September 2017

Trace eyeblink conditioning in the freely moving rat: optimizing the conditioning parameters.

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31 May 2018

The behavioural effects of MK-801: a comparison with antagonists acting non-competitively and competitively at the NMDA receptor.

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31 May 2018

Apparent desensitization of NMDA responses in xenopus oocytes involves calcium-dependent chloride current

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31 May 2018

Hippocampus-dependent learning facilitated by a monoclonal antibody or D-cycloserine

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31 May 2018

The influence of prior synaptic activity on the induction of long-term potentiation

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31 May 2018

Safety and efficacy of repeated-dose intravenous ketamine for treatment-resistant depression

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RESEARCH: Validation of the Massachusetts General Hospital Antidepressant Treatment History Questionnaire (ATRQ).

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28 November 2018

Antidepressants reverse the attenuation of the neurotrophic MEK/MAPK cascade in frontal cortex by elevated platform stress; reversal of effects on LTP is associated with GluA1 phosphorylation

1 reference

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Cannabinoid CB(1) receptor antagonist rimonabant attenuates reinstatement of ketamine conditioned place preference in rats

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28 November 2018

Metaplasticity: tuning synapses and networks for plasticity.

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Involvement of AMPA receptor phosphorylation in antidepressant actions with special reference to tianeptine

1 reference

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28 November 2018

A double-blind, placebo-controlled study of memantine in the treatment of major depression

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28 November 2018

Glycine binding primes NMDA receptor internalization

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Severe impairment of NMDA receptor function in mice carrying targeted point mutations in the glycine binding site results in drug-resistant nonhabituating hyperactivity.

1 reference

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28 November 2018

Subunit specificity and mechanism of action of NMDA partial agonist D-cycloserine

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28 November 2018

Hippocampal lesions prevent trace eyeblink conditioning in the freely moving rat.

1 reference

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28 November 2018

Differential effects of ketamine on gating of auditory evoked potentials and prepulse inhibition in rats

1 reference

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28 November 2018

Autophosphorylation-dependent targeting of calcium/ calmodulin-dependent protein kinase II by the NR2B subunit of the N-methyl- D-aspartate receptor

1 reference

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28 November 2018

Regional and developmental heterogeneity in splicing of the rat brain NMDAR1 mRNA.

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4721220

28 November 2018

Differential expression of five N-methyl-D-aspartate receptor subunit mRNAs in the cerebellum of developing and adult rats.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4721220

28 November 2018

Developmental changes in distribution of NMDA receptor channel subunit mRNAs.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4721220

28 November 2018

Identifiers

10.1517/13543784.2014.852536

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24251380%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24251380%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

PubMed publication ID

2 references

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24251380%20AND%20SRC:MED&resulttype=core&format=json

1 March 2020

ResearchGate publication ID

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