(Q27027243)

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Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies

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scholarly article

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22235997%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

Immunology in the clinic review series; focus on cancer: double trouble for tumours: bi-functional and redirected T cells as effective cancer immunotherapies (English)

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22235997%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

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Europe PubMed Central

PubMed publication ID

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20 January 2020

author name string

L A Marr

1

1 reference

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PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22235997%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

J D M Campbell

3

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PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22235997%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

A R Fraser

4

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Europe PubMed Central

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20 January 2020

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publication date

1 February 2012

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20 January 2020

Clinical and Experimental Immunology

2 references

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22235997%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

167

2 references

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22235997%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

2

2 references

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22235997%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

216-225

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22235997%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

T cells with chimeric antigen receptors have potent antitumor effects and can establish memory in patients with advanced leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

21 March 2017

Gene therapy with human and mouse T-cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

21 March 2017

Adoptive cell transfer: a clinical path to effective cancer immunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

21 March 2017

Cancer regression in patients after transfer of genetically engineered lymphocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

21 March 2017

Adoptive cell transfer therapy following non-myeloablative but lymphodepleting chemotherapy for the treatment of patients with refractory metastatic melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

21 March 2017

Retroviral transduction of peptide stimulated t cells can generate dual t cell receptor-expressing (bifunctional) t cells reactive with two defined antigens

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

21 March 2017

TCRs Used in Cancer Gene Therapy Cross-React with MART-1/Melan-A Tumor Antigens via Distinct Mechanisms

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

21 March 2017

Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

21 March 2017

Tumor regression in patients with metastatic synovial cell sarcoma and melanoma using genetically engineered lymphocytes reactive with NY-ESO-1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

7 April 2017

Case report of a serious adverse event following the administration of T cells transduced with a chimeric antigen receptor recognizing ERBB2

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

7 April 2017

Safety and persistence of adoptively transferred autologous CD19-targeted T cells in patients with relapsed or chemotherapy refractory B-cell leukemias

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

7 April 2017

Virus-specific T cells engineered to coexpress tumor-specific receptors: persistence and antitumor activity in individuals with neuroblastoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

7 April 2017

In vitro comparison of three different chimeric receptor-modified effector T-cell populations for leukemia cell therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

T cells targeting carcinoembryonic antigen can mediate regression of metastatic colorectal cancer but induce severe transient colitis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Comparison of anti-CD3 and anti-CD28-coated beads with soluble anti-CD3 for expanding human T cells: differing impact on CD8 T cell phenotype and responsiveness to restimulation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically engineered to recognize CD19

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Selective expansion of chimeric antigen receptor-targeted T-cells with potent effector function using interleukin-4.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Application of adoptive T-cell therapy using tumor antigen-specific T-cell receptor gene transfer for the treatment of human leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Selected murine residues endow human TCR with enhanced tumor recognition

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Building better chimeric antigen receptors for adoptive T cell therapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Genetic redirection of T cells for cancer therapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Adoptive T cell therapy of cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Enhancing adoptive immunotherapy of cancer.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

T cell receptor gene therapy: strategies for optimizing transgenic TCR pairing

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Engineering lymphocyte subsets: tools, trials and tribulations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Relationship of p53 overexpression on cancers and recognition by anti-p53 T cell receptor-transduced T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

A herceptin-based chimeric antigen receptor with modified signaling domains leads to enhanced survival of transduced T lymphocytes and antitumor activity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Safety and immunologic effects of IL-15 administration in nonhuman primates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Immunotherapy for osteosarcoma: genetic modification of T cells overcomes low levels of tumor antigen expression.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Functionally active virus-specific T cells that target CMV, adenovirus, and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

The promise and potential pitfalls of chimeric antigen receptors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Adoptive transfer of virus-specific and tumor-specific T cell immunity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Genetic manipulation of tumor-specific cytotoxic T lymphocytes to restore responsiveness to IL-7.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

TCR transgenes and transgene cassettes for TCR gene therapy: status in 2008.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Increasing functional avidity of TCR-redirected T cells by removing defined N-glycosylation sites in the TCR constant domain

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Lentiviral vectors encoding human MUC1-specific, MHC-unrestricted single-chain TCR and a fusion suicide gene: potential for universal and safe cancer immunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Limited tumor infiltration by activated T effector cells restricts the therapeutic activity of regulatory T cell depletion against established melanoma

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Antitumor activity of EBV-specific T lymphocytes transduced with a dominant negative TGF-beta receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Redirecting specificity of T-cell populations for CD19 using the Sleeping Beauty system

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Sleeping Beauty transposon-mediated engineering of human primary T cells for therapy of CD19+ lymphoid malignancies

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Adoptive transfer of effector CD8+ T cells derived from central memory cells establishes persistent T cell memory in primates

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

A phase I study on adoptive immunotherapy using gene-modified T cells for ovarian cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Programming CD8+ T cells for effective immunotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

A chimeric T cell antigen receptor that augments cytokine release and supports clonal expansion of primary human T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Exploiting T cell receptor genes for cancer immunotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 September 2017

Gene-engineered varicella-zoster virus reactive CD4+ cytotoxic T cells exert tumor-specific effector function

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

31 May 2018

Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Retroviral transfer of a dominant TCR prevents surface expression of a large proportion of the endogenous TCR repertoire in human T cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Lethal graft-versus-host disease in mouse models of T cell receptor gene therapy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Carving the CAR.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Adoptive immunotherapy with genetically engineered T cells: modification of the IgG1 Fc 'spacer' domain in the extracellular moiety of chimeric antigen receptors avoids 'off-target' activation and unintended initiation of an innate immune response

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Retargeting of human T cells to tumor-associated MUC1: the evolution of a chimeric antigen receptor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Addition of the CD28 signaling domain to chimeric T-cell receptors enhances chimeric T-cell resistance to T regulatory cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Epstein-Barr virus-specific human T lymphocytes expressing antitumor chimeric T-cell receptors: potential for improved immunotherapy

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Kinetic preservation of dual specificity of coprogrammed minor histocompatibility antigen-reactive virus-specific T cells

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Antitumor activity of dual-specific T cells and influenza virus

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Epstein-Barr virus sustains tumor killers

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Transfer of mRNA encoding recombinant immunoreceptors reprograms CD4+ and CD8+ T cells for use in the adoptive immunotherapy of cancer.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Making and circumventing tolerance to cancer.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Human gammadelta T cells as mediators of chimaeric-receptor redirected anti-tumour immunity

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Ex vivo expansion protocol for human tumor specific T cells for adoptive T cell therapy.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Targeting the Wilms tumor antigen 1 by TCR gene transfer: TCR variants improve tetramer binding but not the function of gene modified human T cells.

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Generation of multi-functional antigen-specific human T-cells by lentiviral TCR gene transfer

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRζ /CD28 receptor

1 reference

https://api.crossref.org/works/10.1111%2FJ.1365-2249.2011.04517.X

21 January 2018

Adaptive immunity maintains occult cancer in an equilibrium state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3278687

28 November 2018

Chimeric receptors providing both primary and costimulatory signaling in T cells from a single gene product

1 reference

https://pubmed.ncbi.nlm.nih.gov/22235997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

IL-13 receptor-alpha2: a novel target for cancer therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22235997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens

1 reference

https://pubmed.ncbi.nlm.nih.gov/22235997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of metastatic renal cell carcinoma with autologous T-lymphocytes genetically retargeted against carbonic anhydrase IX: first clinical experience

1 reference

https://pubmed.ncbi.nlm.nih.gov/22235997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Use of tumor-infiltrating lymphocytes and interleukin-2 in the immunotherapy of patients with metastatic melanoma. A preliminary report

1 reference

https://pubmed.ncbi.nlm.nih.gov/22235997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cellular Immunotherapy of Cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22235997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Redirected tumor-specific allogeneic T cells for universal treatment of cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22235997

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1111/J.1365-2249.2011.04517.X

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22235997%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

PMC publication ID

1 reference

PubMed publication ID

2 references

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:22235997%20AND%20SRC:MED&resulttype=core&format=json

20 January 2020

ResearchGate publication ID

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