(Q27309875)

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CCN family member 2/connective tissue growth factor (CCN2/CTGF) has anti-aging effects that protect articular cartilage from age-related degenerative changes

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CCN family member 2/connective tissue growth factor (CCN2/CTGF) has anti-aging effects that protect articular cartilage from age-related degenerative changes (English)

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connective tissue

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Takashi Yamashiro

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Takashi Yamashiro

6

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author name string

Shinsuke Itoh

1

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Takako Hattori

2

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Nao Tomita

3

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Eriko Aoyama

4

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Yasutaka Yutani

5

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Masaharu Takigawa

7

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publication date

2013

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8

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8

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e71156

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Creative Commons Attribution 4.0 International

12 August 2013

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April 2022 Public Data File from Crossref

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The role of CCN2 in cartilage and bone development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

21 March 2017

CT domain of CCN2/CTGF directly interacts with fibronectin and enhances cell adhesion of chondrocytes through integrin alpha5beta1

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

21 March 2017

Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

21 March 2017

Expression of early and late differentiation markers (proliferating cell nuclear antigen, syndecan-3, annexin VI, and alkaline phosphatase) by human osteoarthritic chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

21 March 2017

Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

21 March 2017

Sox9 is required for cartilage formation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

21 March 2017

Structure and function of matrix metalloproteinases and TIMPs

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

10 May 2017

Cartilage-specific over-expression of CCN family member 2/connective tissue growth factor (CCN2/CTGF) stimulates insulin-like growth factor expression and bone growth

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

28 September 2017

The postnatal role of Sox9 in cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

28 September 2017

New hope for the treatment of osteoarthritis through selective inhibition of MMP-13.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

28 September 2017

PTHrP overexpression partially inhibits a mechanical strain-induced arthritic phenotype in chondrocytes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

28 September 2017

Transcriptional regulation of chondrogenesis by coactivator Tip60 via chromatin association with Sox9 and Sox5.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

28 September 2017

Endochondral ossification signals in cartilage degradation during osteoarthritis progression in experimental mouse models.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

28 September 2017

Development of musculoskeletal toxicity without clear benefit after administration of PG-116800, a matrix metalloproteinase inhibitor, to patients with knee osteoarthritis: a randomized, 12-month, double-blind, placebo-controlled study

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

28 September 2017

The pericellular matrix as a transducer of biomechanical and biochemical signals in articular cartilage.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

28 September 2017

Role of CTGF/HCS24/ecogenin in skeletal growth control

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

28 September 2017

Lessons from animal models of osteoarthritis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

28 September 2017

Effects of CTGF/Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

28 September 2017

The deformation behavior and mechanical properties of chondrocytes in articular cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

28 September 2017

Pathophysiology of osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

28 September 2017

Independent expression of fibril-forming collagens I, II, and III in chondrocytes of human osteoarthritic cartilage

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

28 September 2017

Gene expression during osteogenic differentiation in mandibular condyles in vitro

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

28 September 2017

Aging and osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

31 May 2018

Mechanical impact induces cartilage degradation via mitogen activated protein kinases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

31 May 2018

Type X collagen, a natural component of mouse articular cartilage: association with growth, aging, and osteoarthritis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

31 May 2018

Purification of an angiogenesis inhibitor from culture medium conditioned by a human chondrosarcoma-derived chondrocytic cell line, HCS-2/8.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

31 May 2018

Degenerative joint disease in the mouse knee; radiological and morphological observations

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3741357

31 May 2018

Regeneration of defects in articular cartilage in rat knee joints by CCN2 (connective tissue growth factor).

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071156

21 January 2018

Osteoarthritis: Is it a disease of cartilage or of bone?

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071156

21 January 2018

Is osteoarthritis a systemic disorder of bone?

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071156

21 January 2018

Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071156

21 January 2018

Expression of collagen type I and type II in consecutive stages of human osteoarthritis.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071156

21 January 2018

Contribution of runt-related transcription factor 2 to the pathogenesis of osteoarthritis in mice after induction of knee joint instability.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071156

21 January 2018

Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071156

21 January 2018

Collagen type X: a component of the surface of normal human, pig, and rat articular cartilage.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071156

21 January 2018

Cyclic equibiaxial tensile strain induces both anabolic and catabolic responses in articular chondrocytes

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071156

21 January 2018

Generation of Monoclonal Rheumatoid Factors after Immunization with Collagen II-Anti-Collagen II Immune Complexes

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071156

21 January 2018

Localization of type X collagen in the intervertebral disc of mature beagle dogs

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0071156

21 January 2018

Radiological scoring of osteoarthritis progression in STR/ORT mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, stimulates proliferation and differentiation, but not hypertrophy of cultured articular chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Chondrocyte differentiation in human osteoarthritis: expression of osteocalcin in normal and osteoarthritic cartilage and bone

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Autocrine regulation of collagenase 3 (matrix metalloproteinase 13) during osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteopontin is expressed by adult human osteoarthritic chondrocytes: protein and mRNA analysis of normal and osteoarthritic cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Regulation of osteoarthritis development by Wnt-beta-catenin signaling through the endochondral ossification process

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Activation of collagen type II expression in osteoarthritic and rheumatoid cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cyclic tensile stretch on bovine articular chondrocytes inhibits protein kinase C activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Natural history of degenerative joint disease in small laboratory animals. I. Pathological anatomy of degenerative joint disease in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type X collagen synthesis in human osteoarthritic cartilage. Indication of chondrocyte hypertrophy

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CCN family 2/connective tissue growth factor (CCN2/CTGF) stimulates proliferation and differentiation of auricular chondrocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The structure of aggrecan fragments in human synovial fluid. Evidence that aggrecanase mediates cartilage degradation in inflammatory joint disease, joint injury, and osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type X collagen expression in osteoarthritic and rheumatoid articular cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunolocalization of type X collagen in normal fetal and adult osteoarthritic cartilage with monoclonal antibodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Analysis of the type of collagen present in osteoarthritic human cartilage

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

High resolution MR imaging of joint degeneration in the knee of the STR/ORT mouse

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Immunohistological study on collagen in cartilage-bone metamorphosis and degenerative osteoarthrosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A longitudinal analysis of urinary biochemical markers and bone mineral density in STR/Ort mice as a model of spontaneous osteoarthritis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23951098

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1371/JOURNAL.PONE.0071156

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2013PLoSO...871156I

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