(Q27310238)

English

Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model

scientific article (publication date: 2013)

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scholarly article

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Mito-tempol and dexrazoxane exhibit cardioprotective and chemotherapeutic effects through specific protein oxidation and autophagy in a syngeneic breast tumor preclinical model (English)

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breast neoplasm

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based on heuristic

inferred from title

object named as

Jacek Zielonka

10

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author name string

Jennifer S Dickey

1

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Yanira Gonzalez

2

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Baikuntha Aryal

3

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Steven Mog

4

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Asako J Nakamura

5

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Christophe E Redon

6

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Ulrich Baxa

7

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Elliot Rosen

8

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Gang Cheng

9

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Palak Parekh

11

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Karen P Mason

12

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Joy Joseph

13

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Balaraman Kalyanaraman

14

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William Bonner

15

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Eugene Herman

16

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Emily Shacter

17

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V Ashutosh Rao

18

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language of work or name

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publication date

2013

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8

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8

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e70575

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copyright license

Creative Commons CC0 License

5 August 2013

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted, dedicated to the public domain by copyright holder

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

21 March 2017

The antioxidant properties of serum albumin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

21 March 2017

Comparison of the protective effects of amifostine and dexrazoxane against the toxicity of doxorubicin in spontaneously hypertensive rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

21 March 2017

Correlation between serum levels of cardiac troponin-T and the severity of the chronic cardiomyopathy induced by doxorubicin

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

21 March 2017

Anthracycline cardiomyopathy monitored by morphologic changes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

21 March 2017

GammaH2AX and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

7 April 2017

Autophagy upregulation promotes survival and attenuates doxorubicin-induced cardiotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Mitochondrial-targeted nitroxides disrupt mitochondrial architecture and inhibit expression of peroxiredoxin 3 and FOXM1 in malignant mesothelioma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

The antioxidant tempol reduces carcinogenesis and enhances survival in mice when administered after nonlethal total body radiation.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

The dynamic nature of autophagy in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

SST-2 tumor inoculation is a useful model for studying the anti-tumor immune response in SHR rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

The iron chelator Dp44mT inhibits the proliferation of cancer cells but fails to protect from doxorubicin-induced cardiotoxicity in spontaneously hypertensive rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Contribution of the immune system to the chemotherapeutic response.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Cardiotoxicity associated with targeting kinase pathways in cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Tumors induce complex DNA damage in distant proliferative tissues in vivo

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective, randomised, multicentre trial

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

The antioxidant transcription factor Nrf2 negatively regulates autophagy and growth arrest induced by the anticancer redox agent mitoquinone

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Trastuzumab-Induced Cardiotoxicity: Clinical and Prognostic Implications of Troponin I Evaluation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Inhibition of adipogenesis by Tempol in 3T3-L1 cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Cardiotoxicity of anticancer drugs: the need for cardio-oncology and cardio-oncological prevention

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Autophagy, redox signaling, and ventricular remodeling

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Anthracycline-induced cardiotoxicity: overview of studies examining the roles of oxidative stress and free cellular iron

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Results of the Dana-Farber Cancer Institute ALL Consortium Protocol 95-01 for children with acute lymphoblastic leukemia

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Constitutive histone H2AX phosphorylation and ATM activation, the reporters of DNA damage by endogenous oxidants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Chronic inflammation and cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Oxidative modification of proteins during aging

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Determination of carbonyl groups in oxidized proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Preclinical animal models of cardiac protection from anthracycline-induced cardiotoxicity.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Inhibitory effects of malotilate on invasion and metastasis of rat mammary carcinoma cells by modifying the functions of vascular endothelial cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Potential use of nitroxides in radiation oncology.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Cardiotoxicity as a dose-limiting factor in a schedule of high dose bolus therapy with interleukin-2 and alpha-interferon. An unexpectedly frequent complication

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Early structural changes in hypertension: pathophysiology and clinical consequences.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Mechanism of adriamycin cardiotoxicity: evidence for oxidative stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

28 September 2017

Pathogenesis and prevention of doxorubicin cardiomyopathy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

31 May 2018

In vivo tumor growth inhibition produced by a novel sulfonamide, E7010, against rodent and human tumors

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

31 May 2018

Enhanced effect of epidermal growth factor on pulmonary metastasis and in vitro invasion of rat mammary carcinoma cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

31 May 2018

Metastatic capacity and intercellular communication between normal cells and metastatic cell clones derived from a rat mammary carcinoma.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

31 May 2018

Protective effect of ICRF-187 on doxorubicin-induced cardiac and renal toxicity in spontaneously hypertensive (SHR) and normotensive (WKY) rats

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

31 May 2018

Inverse correlation between the metastatic capacity of cell clones derived from a rat mammary carcinoma and their intercellular communication with normal fibroblasts.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

31 May 2018

Metastatic ability and expression of c-fos oncogene in cell clones of a spontaneous rat mammary tumor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

31 May 2018

Inhibition of oxygen-dependent radiation-induced damage by the nitroxide superoxide dismutase mimic, tempol

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3734284

31 May 2018

Antioxidant properties of MitoTEMPOL and its hydroxylamine.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0070575

21 January 2018

γ-H2AX detection in peripheral blood lymphocytes, splenocytes, bone marrow, xenografts, and skin.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0070575

21 January 2018

Oxidative DNA base modifications in peripheral blood mononuclear cells of patients treated with high-dose infusional doxorubicin

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0070575

21 January 2018

The use of serum levels of cardiac troponin T to compare the protective activity of dexrazoxane against doxorubicin- and mitoxantrone-induced cardiotoxicity

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0070575

21 January 2018

Adriamycin-induced autophagic cardiomyocyte death plays a pathogenic role in a rat model of heart failure.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0070575

21 January 2018

The relation between serum albumin levels and risk of coronary heart disease in the Multiple Risk Factor Intervention Trial

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0070575

21 January 2018

Serum alpha 2-macroglobulin and alpha 1-inhibitor 3 concentrations are increased in hypoalbuminemia by post-transcriptional mechanisms

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0070575

21 January 2018

Genetic variation in hypertensive and 'control' strains. What are we controlling for anyway?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23940596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Acute doxorubicin cardiotoxicity involves cardiomyocyte apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23940596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The cardioprotective and DNA topoisomerase II inhibitory agent dexrazoxane (ICRF-187) antagonizes camptothecin-mediated growth inhibition of Chinese hamster ovary cells by inhibition of DNA synthesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/23940596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Tempol, a stable free radical, is a novel murine radiation protector

1 reference

https://pubmed.ncbi.nlm.nih.gov/23940596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Differential susceptibility of plasma proteins to oxidative modification: examination by western blot immunoassay

1 reference

https://pubmed.ncbi.nlm.nih.gov/23940596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

2-Mercaptoethane sulfonate prevents doxorubicin-induced plasma protein oxidation and TNF-α release: implications for the reactive oxygen species-mediated mechanisms of chemobrain

1 reference

https://pubmed.ncbi.nlm.nih.gov/23940596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Rat models of hypertension, cardiac hypertrophy and failure

1 reference

https://pubmed.ncbi.nlm.nih.gov/23940596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Trastuzumab-induced cardiotoxicity: is it time for troponin for all patients?

1 reference

https://pubmed.ncbi.nlm.nih.gov/23940596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Protective effect of the nitroxide tempol against the cardiotoxicity of adriamycin

1 reference

https://pubmed.ncbi.nlm.nih.gov/23940596

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0070575

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2013PLoSO...870575D

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PubMed publication ID

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