(Q27312120)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19593383%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

title

Defects in tRNA modification associated with neurological and developmental dysfunctions in Caenorhabditis elegans elongator mutants (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19593383%20AND%20SRC:MED&resulttype=core&format=json

Probable elongator complex protein 3 CELE_ZK863.3

2 February 2020

main subject

Caenorhabditis elegans

0 references

1 reference

Elongator complex protein 1 CELE_Y110A7A.16

GOA release 2020-03-11

1 reference

Cytoplasmic tRNA 2-thiolation protein 1 CELE_F29C4.6

GOA release 2020-03-11

1 reference

GOA release 2020-03-11

author

Anders Byström

series ordinal

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19593383%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

author name string

Changchun Chen

series ordinal

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19593383%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

Simon Tuck

series ordinal

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19593383%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

language of work or name

English

0 references

publication date

10 July 2009

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19593383%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19593383%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

volume

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19593383%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

issue

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19593383%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

page(s)

e1000561

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19593383%20AND%20SRC:MED&resulttype=core&format=json

Creative Commons Attribution 4.0 International

2 February 2020

copyright license

start time

10 July 2009

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

describes a project that uses

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2702823/fullTextXML

inferred from PubMed Central ID database lookup

cites work

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21 March 2017

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Tomosyn inhibits synaptic vesicle priming in Caenorhabditis elegans

21 March 2017

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Using microarrays to facilitate positional cloning: identification of tomosyn as an inhibitor of neurosecretion

21 March 2017

1 reference

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21 March 2017

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Tissue-specific reduction in splicing efficiency of IKBKAP due to the major mutation associated with familial dysautonomia.

21 March 2017

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Human Elongator facilitates RNA polymerase II transcription through chromatin

21 March 2017

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21 March 2017

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Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods

21 March 2017

1 reference

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Familial dysautonomia is caused by mutations of the IKAP gene

21 March 2017

1 reference

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Tissue-specific expression of a splicing mutation in the IKBKAP gene causes familial dysautonomia

21 March 2017

1 reference

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IKAP is a scaffold protein of the IkappaB kinase complex

21 March 2017

1 reference

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The genetics of Caenorhabditis elegans

21 March 2017

1 reference

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Chemotaxis by the nematode Caenorhabditis elegans: identification of attractants and analysis of the response by use of mutants

21 March 2017

1 reference

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Mechanistic characterization of the sulfur-relay system for eukaryotic 2-thiouridine biogenesis at tRNA wobble positions.

21 March 2017

1 reference

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21 March 2017

1 reference

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A genome-wide screen identifies genes required for formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae

21 March 2017

1 reference

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Thio-modification of yeast cytosolic tRNA requires a ubiquitin-related system that resembles bacterial sulfur transfer systems

21 March 2017

1 reference

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A conserved modified wobble nucleoside (mcm5s2U) in lysyl-tRNA is required for viability in yeast

21 March 2017

1 reference

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Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis.

21 March 2017

1 reference

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An early step in wobble uridine tRNA modification requires the Elongator complex

21 March 2017

1 reference

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Exchange of RNA polymerase II initiation and elongation factors during gene expression in vivo

21 March 2017

1 reference

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Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae

21 March 2017

1 reference

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RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes

21 March 2017

1 reference

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A primordial tRNA modification required for the evolution of life?

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

A novel histone acetyltransferase is an integral subunit of elongating RNA polymerase II holoenzyme

21 March 2017

1 reference

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The essential Gcd10p-Gcd14p nuclear complex is required for 1-methyladenosine modification and maturation of initiator methionyl-tRNA.

21 March 2017

1 reference

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tRNA transfers to the limelight

21 March 2017

1 reference

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The let-7 family of microRNAs

21 March 2017

1 reference

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Saccharomyces cerevisiae Elongator mutations confer resistance to the Kluyveromyces lactis zymocin

21 March 2017

1 reference

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tRNAdb 2009: compilation of tRNA sequences and tRNA genes

21 March 2017

1 reference

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Gene expression profile of aging and its retardation by caloric restriction

7 April 2017

1 reference

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Variants of the elongator protein 3 (ELP3) gene are associated with motor neuron degeneration

7 April 2017

1 reference

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The conserved Wobble uridine tRNA thiolase Ctu1-Ctu2 is required to maintain genome integrity

28 September 2017

1 reference

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tRNA's modifications bring order to gene expression

28 September 2017

1 reference

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Eukaryotic wobble uridine modifications promote a functionally redundant decoding system.

28 September 2017

1 reference

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New modes of translational control in development, behavior, and disease

28 September 2017

1 reference

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eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

Familial dysautonomia: update and recent advances

28 September 2017

1 reference

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Transcription impairment and cell migration defects in elongator-depleted cells: implication for familial dysautonomia

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

Regulation of synaptic transmission by RAB-3 and RAB-27 in Caenorhabditis elegans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

The elongata mutants identify a functional Elongator complex in plants with a role in cell proliferation during organ growth

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

Roles of 5-substituents of tRNA wobble uridines in the recognition of purine-ending codons

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

Elongator's toxin-target (TOT) function is nuclear localization sequence dependent and suppressed by post-translational modification.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

Regulation of peptide-chain elongation in mammalian cells

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

Kluyveromyces lactis zymocin mode of action is linked to RNA polymerase II function via Elongator.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

Guanylyl cyclase expression in specific sensory neurons: a new family of chemosensory receptors.

28 September 2017

1 reference

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Targeted single-cell induction of gene products in Caenorhabditis elegans: a new tool for developmental studies

28 September 2017

1 reference

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Measurement of human tissue protein synthesis: an optimal approach

28 September 2017

1 reference

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Caenorhabditis elegans mutants resistant to inhibitors of acetylcholinesterase

28 September 2017

1 reference

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The primary structures of two arginine tRNAs (anticodons C-C-U and mcm5a2U-C-psi) and of glutamine tRNA (anticodon C-U-G) from bovine liver.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

Molecular mechanism of codon recognition by tRNA species with modified uridine in the first position of the anticodon

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

Chemosensory neurons with overlapping functions direct chemotaxis to multiple chemicals in C. elegans

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

Trm9-catalyzed tRNA modifications link translation to the DNA damage response

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

The Kluyveromyces lactis gamma-toxin targets tRNA anticodons.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

The I kappa B kinase (IKK) complex is tripartite and contains IKK gamma but not IKAP as a regular component.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

MEC-12, an alpha-tubulin required for touch sensitivity in C. elegans

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

Neuronal peptide release is limited by secretory granule mobility

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

The genetics of levamisole resistance in the nematode Caenorhabditis elegans

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

Reinvestigation of the primary structure of brewer's yeast tRNA 3 Arg.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation

31 May 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000561

The Elongator subunit Elp3 contains a Fe4S4 cluster and binds S-adenosylmethionine

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000561

The insulin/PI 3-kinase pathway regulates salt chemotaxis learning in Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000561

Use of targetable gfp-tagged neuropeptide for visualizing neuropeptide release following execution of a behavior

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000561

UNC-31 (CAPS) is required for dense-core vesicle but not synaptic vesicle exocytosis in Caenorhabditis elegans.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000561

Analysis of synaptic transmission in Caenorhabditis elegans using an aldicarb-sensitivity assay.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000561

A novel specific role for I kappa B kinase complex-associated protein in cytosolic stress signaling.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000561

Rapid tRNA decay can result from lack of nonessential modifications.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000561

Structural effects of hypermodified nucleosides in the Escherichia coli and human tRNALys anticodon loop: the effect of nucleosides s2U, mcm5U, mcm5s2U, mnm5s2U, t6A, and ms2t6A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000561

Antagonistic regulation of synaptic vesicle priming by Tomosyn and UNC-13.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000561

Developmental genetics of the mechanosensory neurons of Caenorhabditis elegans

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000561

C. elegans ZAG-1, a Zn-finger-homeodomain protein, regulates axonal development and neuronal differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000561

Elongator, a Multisubunit Component of a Novel RNA Polymerase II Holoenzyme for Transcriptional Elongation

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1000561

An iron-sulfur cluster domain in Elp3 important for the structural integrity of elongator.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

Plasticity of chemotaxis revealed by paired presentation of a chemoattractant and starvation in the nematode Caenorhabditis elegans.

28 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2702823

Presence and coding properties of 2'-O-methyl-5-carbamoylmethyluridine (ncm5Um) in the wobble position of the anticodon of tRNA(Leu) (U*AA) from brewer's yeast

28 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19593383

12 December 2020

inferred from PubMed ID database lookup

IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19593383

12 December 2020

inferred from PubMed ID database lookup

Analysis of action of wobble nucleoside modifications on codon-anticodon pairing within the ribosome

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/19593383

12 December 2020

inferred from PubMed ID database lookup

Identifiers

DOI

10.1371/JOURNAL.PGEN.1000561

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19593383%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

1 reference

2 references

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19593383%20AND%20SRC:MED&resulttype=core&format=json

2 February 2020

PubMed publication ID

19593383

2 references