(Q27316009)

26 June 2017

Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information (English)

1 reference

26 June 2017

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5

1 reference

26 June 2017

11

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26 June 2017

13

1 reference

26 June 2017

Davide Sabbadin

2

0 references

Younis Baqi

Younis Baqi

9

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Stefano Moro

Stefano Moro

12

0 references

Kenneth A. Jacobson

Kenneth A Jacobson

14

0 references

Silvia Paoletta

1

Silvia Paoletta

1 reference

26 June 2017

3

Ivar von Kügelgen

1 reference

26 June 2017

Sonja Hinz

4

1 reference

26 June 2017

Kristina Hoffmann

6

1 reference

26 June 2017

Aliaa Abdelrahman

7

1 reference

26 June 2017

Jens Straßburger

8

1 reference

26 June 2017

Qiang Zhao

10

1 reference

26 June 2017

language of work or name

English

0 references

publication date

21 July 2015

1 reference

Journal of Computer - Aided Molecular Design

26 June 2017

1 reference

26 June 2017

29

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26 June 2017

8

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26 June 2017

737-756

1 reference

https://scigraph.springernature.com/pub.10.1007/s10822-015-9858-z

26 June 2017

0 references

cites work

Agonist-bound structure of the human P2Y12 receptor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Structure of the human P2Y12 receptor in complex with an antithrombotic drug

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Identification of the platelet ADP receptor targeted by antithrombotic drugs

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Scalable molecular dynamics with NAMD

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

VMD: visual molecular dynamics

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

P2Y12, a new platelet ADP receptor, target of clopidogrel

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Glide: a new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Antiplatelet activity, P2Y₁ and P2Y₁₂ inhibition, and metabolism in plasma of stereoisomers of diadenosine 5',5'″-P¹ ,P⁴-dithio-P²,P³-chloromethylenetetraphosphate

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Buried chloride stereochemistry in the Protein Data Bank

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Nucleotides Acting at P2Y Receptors: Connecting Structure and Function

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Central P2Y12 receptor blockade alleviates inflammatory and neuropathic pain and cytokine production in rodents

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

5-alkyl-1,3-oxazole derivatives of 6-amino-nicotinic acids as alkyl ester bioisosteres are antagonists of the P2Y12 receptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Identification of determinants required for agonistic and inverse agonistic ligand properties at the ADP receptor P2Y12.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Pharmacochemistry of the platelet purinergic receptors.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Comparison of three GPCR structural templates for modeling of the P2Y12 nucleotide receptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Wordom: a user-friendly program for the analysis of molecular structures, trajectories, and free energy surfaces

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Are we living in the end of the blockbuster drug era?

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Piperazinyl glutamate pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Ticagrelor: the first reversibly binding oral P2Y12 receptor antagonist

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Involvement of basic amino acid residues in transmembrane regions 6 and 7 in agonist and antagonist recognition of the human platelet P2Y(12)-receptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Lipophilic modifications to dinucleoside polyphosphates and nucleotides that confer antagonist properties at the platelet P2Y12 receptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Novel procedure for modeling ligand/receptor induced fit effects.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Adenine triphosphate nucleotides are antagonists at the P2Y receptor.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Cellular distribution and functions of P2 receptor subtypes in different systems

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Induction of novel agonist selectivity for the ADP-activated P2Y1 receptor versus the ADP-activated P2Y12 and P2Y13 receptors by conformational constraint of an ADP analog.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Acyclic analogues of adenosine bisphosphates as P2Y receptor antagonists: phosphate substitution leads to multiple pathways of inhibition of platelet aggregation.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Development and current status of the CHARMM force field for nucleic acids.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Pharmacological receptors on blood platelets

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Analogues of diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) as potential anti-platelet-aggregation agents

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Competitive mode and site of interaction of ticagrelor at the human platelet P2Y12 -receptor

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Lead optimization of ethyl 6-aminonicotinate acyl sulfonamides as antagonists of the P2Y12 receptor. separation of the antithrombotic effect and bleeding for candidate drug AZD1283.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Modified diadenosine tetraphosphates with dual specificity for P2Y1 and P2Y12 are potent antagonists of ADP-induced platelet activation.

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Identification of high-affinity P2Y₁₂ antagonists based on a phenylpyrazole glutamic acid piperazine backbone

31 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4536181

Effects of 5'-phosphate derivatives of 2-hexynyl adenosine and 2-phenylethynyl adenosine on responses of human platelets mediated by P2Y receptors.

31 May 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10822-015-9858-Z

Novel tricyclic benzothiazolo[2,3-c]thiadiazine antagonists of the platelet ADP receptor (P2Y(12)).

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10822-015-9858-Z

Synthesis, structure-property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y₁₂ receptor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10822-015-9858-Z

High-affinity, non-nucleotide-derived competitive antagonists of platelet P2Y12 receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10822-015-9858-Z

Piperazinyl-glutamate-pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10822-015-9858-Z

Part II: piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10822-015-9858-Z

Carba-nucleosides as potent antagonists of the adenosine 5'-diphosphate (ADP) purinergic receptor (P2Y12 on human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10822-015-9858-Z

Adenosine analogues as inhibitors of P2Y12 receptor mediated platelet aggregation

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10822-015-9858-Z

Synthesis and biological evaluation of cyclopentyl-triazolol-pyrimidine (CPTP) based P2Y12 antagonists

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10822-015-9858-Z

Agonist and antagonist effects of diadenosine tetraphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2X1 receptors.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10822-015-9858-Z

N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10822-015-9858-Z

Interaction of new, very potent non-nucleotide antagonists with Arg256 of the human platelet P2Y12 receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10822-015-9858-Z

Supervised molecular dynamics (SuMD) as a helpful tool to depict GPCR-ligand recognition pathway in a nanosecond time scale.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10822-015-9858-Z

Perturbation of fluid dynamics properties of water molecules during G protein-coupled receptor-ligand recognition: the human A2A adenosine receptor as a key study.

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10822-015-9858-Z

Novel P2Y12 adenosine diphosphate receptor antagonists for inhibition of platelet aggregation (II): pharmacodynamic and pharmacokinetic characterization

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10822-015-9858-Z

Identification and analysis of functionally important amino acids in human purinergic 12 receptor using a Saccharomyces cerevisiae expression system

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS10822-015-9858-Z

A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y12 receptor

21 January 2018

1 reference

12 December 2020

Antagonists of the platelet P2T receptor: a novel approach to antithrombotic therapy

1 reference

12 December 2020

Thienopyrimidine-based P2Y12 platelet aggregation inhibitors

1 reference

12 December 2020

From ATP to AZD6140: the discovery of an orally active reversible P2Y12 receptor antagonist for the prevention of thrombosis

1 reference

12 December 2020

10.1007/S10822-015-9858-Z

Identifiers

DOI

1 reference

journals/jcamd/PaolettaSKHKHAS15

26 June 2017

1 reference

DBLP Dataset 2021-01-02

Dimensions Publication ID

28 January 2021

1019696814

0 references

Fatcat ID

release_mbohcwgm5vehhn2juwpmmkz45m

0 references

0 references

1 reference