(Q27317096)

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DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans

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7 March 2020

DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans (English)

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7 March 2020

Caenorhabditis elegans

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7 March 2020

Jennifer Tullet

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7 March 2020

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7 March 2020

Alexandre Benedetto

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7 March 2020

Irene Papatheodorou

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Eugene Schuster

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7 March 2020

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Caroline Araiz

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Matthew J Sanders

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Emily Clark

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7 March 2020

Daniel Jones

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7 March 2020

Kathrin Schmeisser

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7 March 2020

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7 March 2020

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7 March 2020

e1004109

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7 March 2020

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6 February 2014

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Structure of mammalian AMPK and its regulation by ADP

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Structural basis for AMP binding to mammalian AMP-activated protein kinase

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Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans

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The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans

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Glycogen storage disease as a unifying mechanism of disease in the PRKAG2 cardiac syndrome

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FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis

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Activation of AMPK by the putative dietary restriction mimetic metformin is insufficient to extend lifespan in Drosophila

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21 March 2017

daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

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Ribosomal protein S6 kinase 1 signaling regulates mammalian life span

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Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans

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FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress

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Opposing activities protect against age-onset proteotoxicity

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Regulation of Aging and Age-Related Disease by DAF-16 and Heat-Shock Factor

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PCR fusion-based approach to create reporter gene constructs for expression analysis in transgenic C. elegans

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daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditis elegans

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Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling

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Signals from the reproductive system regulate the lifespan of C. elegans

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Reduced insulin/insulin-like growth factor-1 signaling and dietary restriction inhibit translation but preserve muscle mass in Caenorhabditis elegans

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Adenosine nucleotide biosynthesis and AMPK regulate adult life span and mediate the longevity benefit of caloric restriction in flies.

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Direct and indirect gene regulation by a life-extending FOXO protein in C. elegans: roles for GATA factors and lipid gene regulators

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AMP-activated protein kinase (AMPK) controls the aging process via an integrated signaling network

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AMP-activated protein kinase: also regulated by ADP?

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Lifespan extension induced by AMPK and calcineurin is mediated by CRTC-1 and CREB

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DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO

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31 May 2018

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31 May 2018

The AMP-activated protein kinase AAK-2 links energy levels and insulin-like signals to lifespan in C. elegans

1 reference

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31 May 2018

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31 May 2018

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21 January 2018

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21 January 2018

RPN-6 determines C. elegans longevity under proteotoxic stress conditions

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21 January 2018

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21 January 2018

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21 January 2018

N488I mutation of the gamma2-subunit results in bidirectional changes in AMP-activated protein kinase activity

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https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004109

21 January 2018

Loss of the putative RNA-directed RNA polymerase RRF-3 makes C. elegans hypersensitive to RNAi

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004109

21 January 2018

Tissue-specific activities of C. elegans DAF-16 in the regulation of lifespan

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004109

21 January 2018

Regulation of C. elegans longevity by specific gustatory and olfactory neurons

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004109

21 January 2018

Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004109

21 January 2018

Vector-free DNA constructs improve transgene expression in C. elegans

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PGEN.1004109

21 January 2018

Increased alpha2 subunit-associated AMPK activity and PRKAG2 cardiomyopathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Microarray analysis of gene expression with age in individual nematodes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516399

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PGEN.1004109

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24516399%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24516399%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24516399%20AND%20SRC:MED&resulttype=core&format=json

7 March 2020

ResearchGate publication ID

0 references

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