(Q27334288)

2

0 references

Doug Bowman

3

0 references

Vaishali Shinde

4

0 references

Kerri Lasky

5

0 references

Judy Shi

6

0 references

Tricia Vos

7

0 references

Bradley Stringer

8

0 references

Ben Amidon

9

0 references

Natalie D'Amore

10

0 references

Marc L Hyer

Creative Commons Attribution 4.0 International

11

0 references

language of work or name

English

0 references

publication date

2014

0 references

published in

PLOS One

0 references

volume

9

0 references

issue

11

0 references

page(s)

e111060

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copyright license

start time

3 November 2014

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

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Polo-like kinase 1 phosphorylation of G2 and S-phase-expressed 1 protein is essential for p53 inactivation during G2 checkpoint recovery

21 March 2017

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BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activity

21 March 2017

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Quantitative live imaging of cancer and normal cells treated with Kinesin-5 inhibitors indicates significant differences in phenotypic responses and cell fate

21 March 2017

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Polo-like kinase controls vertebrate spindle elongation and cytokinesis

21 March 2017

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Mammalian cells lack checkpoints for tetraploidy, aberrant centrosome number, and cytokinesis failure

21 March 2017

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Antibody microinjection reveals an essential role for human polo-like kinase 1 (Plk1) in the functional maturation of mitotic centrosomes

21 March 2017

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A biomarker that identifies senescent human cells in culture and in aging skin in vivo

21 March 2017

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Bora and the kinase Aurora a cooperatively activate the kinase Plk1 and control mitotic entry

21 March 2017

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Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

21 March 2017

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Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

7 April 2017

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Human cells enter mitosis with damaged DNA after treatment with pharmacological concentrations of genotoxic agents

7 April 2017

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MLN0905, a small-molecule plk1 inhibitor, induces antitumor responses in human models of diffuse large B-cell lymphoma

29 September 2017

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Plk1 regulates the kinesin-13 protein Kif2b to promote faithful chromosome segregation.

29 September 2017

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TAK-960, a novel, orally available, selective inhibitor of polo-like kinase 1, shows broad-spectrum preclinical antitumor activity in multiple dosing regimens

29 September 2017

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Prolonged mitotic arrest triggers partial activation of apoptosis, resulting in DNA damage and p53 induction

29 September 2017

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Chromosome segregation errors as a cause of DNA damage and structural chromosome aberrations

29 September 2017

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Polo-box domain inhibitor poloxin activates the spindle assembly checkpoint and inhibits tumor growth in vivo

29 September 2017

1 reference

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Continuous polo-like kinase 1 activity regulates diffusion to maintain centrosome self-organization during mitosis.

29 September 2017

1 reference

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Differential control of Eg5-dependent centrosome separation by Plk1 and Cdk1

29 September 2017

1 reference

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MLN8054, an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo

29 September 2017

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Centromere-localized breaks indicate the generation of DNA damage by the mitotic spindle.

29 September 2017

1 reference

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Targeted depletion of Polo-like kinase (Plk) 1 through lentiviral shRNA or a small-molecule inhibitor causes mitotic catastrophe and induction of apoptosis in human melanoma cells

29 September 2017

1 reference

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Polo-like kinase 1 depletion induces DNA damage in early S prior to caspase activation

29 September 2017

1 reference

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Deficiency in chromosome congression by the inhibition of Plk1 polo box domain-dependent recognition

29 September 2017

1 reference

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Cancer cells display profound intra- and interline variation following prolonged exposure to antimitotic drugs.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

Plx1 is required for chromosomal DNA replication under stressful conditions

29 September 2017

1 reference

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Plk1 depletion in nontransformed diploid cells activates the DNA-damage checkpoint

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

Human cancer cells commonly acquire DNA damage during mitotic arrest

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis

29 September 2017

1 reference

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Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

Antitumor activity of MLN8054, an orally active small-molecule inhibitor of Aurora A kinase

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

BI 2536, a potent and selective inhibitor of polo-like kinase 1, inhibits tumor growth in vivo.

29 September 2017

1 reference

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Therapy-induced tumor immunosurveillance involves IFN-producing killer dendritic cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

Inhibitory effect of Polo-like kinase 1 depletion on mitosis and apoptosis of gastric cancer cells

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

The role of Polo-like kinase 1 in the inhibition of centrosome separation after ionizing radiation

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

SW480, a p53 double-mutant cell line retains proficiency for some p53 functions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

Polo-like kinase-1 is required for bipolar spindle formation but is dispensable for anaphase promoting complex/Cdc20 activation and initiation of cytokinesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

THE VINCA ALKALOIDS: A NEW CLASS OF ONCOLYTIC AGENTS.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

Tumor cell senescence in cancer treatment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

Mechanism of action of antitumor drugs that interact with microtubules and tubulin

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

Dominant-negative polo-like kinase 1 induces mitotic catastrophe independent of cdc25C function

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

Cell type variation in responses to antimitotic drugs that target microtubules and kinesin-5.

2 June 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0111060

Roles of polo-like kinase 1 in the assembly of functional mitotic spindles

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0111060

Polo-like kinase 1 facilitates chromosome alignment during prometaphase through BubR1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0111060

Downregulation of Polo-like kinase 1 induces cellular senescence in human primary cells through a p53-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0111060

Sustained mitotic block elicits DNA breaks: one-step alteration of ploidy and chromosome integrity in mammalian cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0111060

Polo-like kinase-1 is a target of the DNA damage checkpoint

21 January 2018

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0111060

DNA damage is able to induce senescence in tumor cells in vitro and in vivo.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4218841

A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy

27 November 2018

1 reference

12 December 2020

Effect of RNA silencing of polo-like kinase-1 (PLK1) on apoptosis and spindle formation in human cancer cells

1 reference

12 December 2020

A role for both RB and p53 in the regulation of human cellular senescence

1 reference

12 December 2020

A senescence-like phenotype distinguishes tumor cells that undergo terminal proliferation arrest after exposure to anticancer agents

1 reference

12 December 2020

Role of p53 and p21waf1/cip1 in senescence-like terminal proliferation arrest induced in human tumor cells by chemotherapeutic drugs

1 reference

12 December 2020

Mitotic DNA damage response: Polo-like kinase-1 is dephosphorylated through ATM-Chk1 pathway

1 reference

12 December 2020

The polo-like kinase 1 regulates CDC25B-dependent mitosis entry

1 reference

12 December 2020

10.1371/JOURNAL.PONE.0111060

Identifiers

DOI

1 reference

ADS bibcode

2014PLoSO...9k1060D

0 references

1 reference

1 reference

PubMed publication ID

25365521

1 reference