(Q27347707)

26 June 2017

title

Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man. (English)

1 reference

26 June 2017

0 references

19

Christopher J Winrow

Christopher J

Winrow

1 reference

26 June 2017

Anthony L Gotter

1

Anthony L

Gotter

1 reference

26 June 2017

Mark S Forman

2

Mark S

Forman

1 reference

26 June 2017

Charles M Harrell

3

Charles M

Harrell

1 reference

26 June 2017

Joanne Stevens

4

Joanne

Stevens

1 reference

26 June 2017

Vladimir Svetnik

5

Vladimir

Svetnik

1 reference

26 June 2017

Ka Lai Yee

6

Ka Lai

Yee

1 reference

26 June 2017

Xiaodong Li

7

Xiaodong

Li

1 reference

26 June 2017

Anthony J Roecker

8

Anthony J

Roecker

1 reference

26 June 2017

Steven V Fox

9

Steven V

Fox

1 reference

26 June 2017

Pamela L Tannenbaum

10

Pamela L

Tannenbaum

1 reference

26 June 2017

Susan L Garson

11

Susan L

Garson

1 reference

26 June 2017

Inge De Lepeleire

12

Inge De

Lepeleire

1 reference

26 June 2017

Nicole Calder

13

Nicole

Calder

1 reference

26 June 2017

Laura Rosen

14

Laura

Rosen

1 reference

26 June 2017

Arie Struyk

15

Arie

Struyk

1 reference

26 June 2017

Paul J Coleman

16

Paul J

Coleman

1 reference

26 June 2017

W Joseph Herring

17

W Joseph

Herring

1 reference

26 June 2017

John J Renger

18

John J

Renger

1 reference

26 June 2017

language of work or name

English

0 references

publication date

3 June 2016

1 reference

26 June 2017

1 reference

26 June 2017

volume

6

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26 June 2017

page(s)

27147

1 reference

Creative Commons Attribution 4.0 International

26 June 2017

copyright license

start time

1 June 2016

1 reference

April 2022 Public Data File from Crossref

copyright status

copyrighted

0 references

cites work

Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone

1 reference

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The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene

21 March 2017

1 reference

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Discovery of 5''-chloro-N-[(5,6-dimethoxypyridin-2-yl)methyl]-2,2':5',3''-terpyridine-3'-carboxamide (MK-1064): a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia

21 March 2017

2 references

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21 March 2017

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The orexin antagonist SB-649868 promotes and maintains sleep in men with primary insomnia

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Differential effects of a dual orexin receptor antagonist (SB-649868) and zolpidem on sleep initiation and consolidation, SWS, REM sleep, and EEG power spectra in a model of situational insomnia

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Phase I studies on the safety, tolerability, pharmacokinetics and pharmacodynamics of SB-649868, a novel dual orexin receptor antagonist

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Evidence implicating a role for orexin-1 receptor modulation of paradoxical sleep in the rat

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Proposed supplements and amendments to 'A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects', the Rechtschaffen & Kales (1968) standard

21 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Effects of suvorexant on sleep architecture and power spectral profile in patients with insomnia: analysis of pooled phase 3 data

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Characterization of JNJ-42847922, a Selective Orexin-2 Receptor Antagonist, as a Clinical Candidate for the Treatment of Insomnia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Differential sleep-promoting effects of dual orexin receptor antagonists and GABAA receptor modulators

29 September 2017

1 reference

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Electroencephalographic power spectral density profile of the orexin receptor antagonist suvorexant in patients with primary insomnia and healthy subjects

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Orexin-1 receptor blockade dysregulates REM sleep in the presence of orexin-2 receptor antagonism

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Quantitative electroencephalography within sleep/wake states differentiates GABAA modulators eszopiclone and zolpidem from dual orexin receptor antagonists in rats

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Orexin receptor antagonism, a new sleep-enabling paradigm: a proof-of-concept clinical trial.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Pharmacological characterization of MK-6096 - a dual orexin receptor antagonist for insomnia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Promotion of sleep by suvorexant-a novel dual orexin receptor antagonist

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Knockdown of orexin type 1 receptor in rat locus coeruleus increases REM sleep during the dark period

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Discovery of the dual orexin receptor antagonist [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone (MK-4305) for the treatment of insomnia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Promotion of sleep by targeting the orexin system in rats, dogs and humans

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

The novel brain neuropeptide, orexin-A, modulates the sleep-wake cycle of rats

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Orexin A activates locus coeruleus cell firing and increases arousal in the rat.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Discovery of MK-3697: a selective orexin 2 receptor antagonist (2-SORA) for the treatment of insomnia

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Kinetic properties of "dual" orexin receptor antagonists at OX1R and OX2R orexin receptors

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Distinct effects of IPSU and suvorexant on mouse sleep architecture

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Effects of suvorexant, an orexin receptor antagonist, on sleep parameters as measured by polysomnography in healthy men.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Neuropharmacological characterization of basal forebrain cholinergic stimulated cataplexy in narcoleptic canines

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Effects of thyrotropin-releasing hormone and its analogs on daytime sleepiness and cataplexy in canine narcolepsy

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Electroencephalographic correlates of cataplectic attacks in narcoleptic canines.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Subjective and objective sleepiness in the active individual.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Effects of imipramine, chlorimipramine, and fluoxetine on cataplexy in dogs

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

Hypocretin (orexin) deficiency in human narcolepsy.

2 June 2018

1 reference

Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials

21 January 2018

1 reference

Orexin receptor antagonism for treatment of insomnia: a randomized clinical trial of suvorexant.

21 January 2018

1 reference

Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonism-induced sleep promotion in the rat.

21 January 2018

1 reference

Perifornical orexinergic neurons modulate REM sleep by influencing locus coeruleus neurons in rats

21 January 2018

1 reference

Identification of a novel series of orexin receptor antagonists with a distinct effect on sleep architecture for the treatment of insomnia

21 January 2018

1 reference

Sub-chronic administration of zolpidem affects modifications to rat sleep architecture

21 January 2018

1 reference

Circadian and Homeostatic Regulation of Hypocretin in a Primate Model: Implications for the Consolidation of Wakefulness

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4891657

27 November 2018

Identifiers

DOI

10.1038/SREP27147

1 reference

Dimensions Publication ID

26 June 2017

1000571948

0 references

OpenCitations bibliographic resource ID

1053553

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

1053553

1 reference