(Q27349010)

English

Chronic intranasal treatment with an anti-Aβ(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease

scientific article (publication date: 2011)

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scholarly article

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Chronic intranasal treatment with an anti-Aβ(30-42) scFv antibody ameliorates amyloid pathology in a transgenic mouse model of Alzheimer's disease (English)

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Alzheimer's disease

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based on heuristic

inferred from title

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1 reference

based on heuristic

inferred from title

author name string

Susann Cattepoel

1

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Michael Hanenberg

2

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Luka Kulic

3

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Roger M Nitsch

4

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language of work or name

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publication date

2011

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6

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4

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e18296

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copyright license

Creative Commons Attribution 4.0 International

5 April 2011

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April 2022 Public Data File from Crossref

copyright status

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describes a project that uses

1 reference

Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC3071717/fullTextXML

based on heuristic

inferred from PubMed Central ID database lookup

Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

1 reference

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1 reference

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Passive immunotherapy against Abeta in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

1 reference

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The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

1 reference

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21 March 2017

Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071717

21 March 2017

Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071717

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Amyloid-beta immunotherapy for Alzheimer's disease

1 reference

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Alternative Abeta immunotherapy approaches for Alzheimer's disease

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1 reference

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The toxicity of beta-amyloid is attenuated by interaction with its specific human scFv E3 in vitro

1 reference

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Cerebral amyloid angiopathy: pathogenetic mechanisms and link to dense amyloid plaques.

1 reference

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Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates.

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Epitope mapping and neuroprotective properties of a human single chain FV antibody that binds an internal epitope of amyloid-beta 1-42.

1 reference

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29 September 2017

Intracellular Abeta and cognitive deficits precede beta-amyloid deposition in transgenic arcAbeta mice

1 reference

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29 September 2017

Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response.

1 reference

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Immunology and immunotherapy of Alzheimer's disease

1 reference

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Amelioration of amyloid load by anti-Abeta single-chain antibody in Alzheimer mouse model

1 reference

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T-cells in Alzheimer's disease.

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Engineered antibody fragments and the rise of single domains

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Clinical effects of Abeta immunization (AN1792) in patients with AD in an interrupted trial.

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Intranasal administration of nerve growth factor (NGF) rescues recognition memory deficits in AD11 anti-NGF transgenic mice

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29 September 2017

Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071717

29 September 2017

Single chain variable fragments against beta-amyloid (Abeta) can inhibit Abeta aggregation and prevent abeta-induced neurotoxicity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071717

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Is nose-to-brain transport of drugs in man a reality?

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Direct in vivo screening of intrabody libraries constructed on a highly stable single-chain framework

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Sniffing neuropeptides: a transnasal approach to the human brain

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Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease

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Antigen-independent selection of stable intracellular single-chain antibodies

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Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071717

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A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

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Delivery of interferon-beta to the monkey nervous system following intranasal administration

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2 June 2018

Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071717

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Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071717

2 June 2018

Generation of antibodies specific for beta-amyloid by vaccination of patients with Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

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Antibodies against beta-amyloid slow cognitive decline in Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

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Cerebral hemorrhage after passive anti-Abeta immunotherapy.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Deglycosylated anti-amyloid-beta antibodies eliminate cognitive deficits and reduce parenchymal amyloid with minimal vascular consequences in aged amyloid precursor protein transgenic mice.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Modulation of Alzheimer's beta-amyloid neurotoxicity by site-directed single-chain antibody.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Single chain Fv antibodies against the 25-35 Abeta fragment inhibit aggregation and toxicity of Abeta42.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Intracranial adeno-associated virus-mediated delivery of anti-pan amyloid beta, amyloid beta40, and amyloid beta42 single-chain variable fragments attenuates plaque pathology in amyloid precursor protein mice.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Assessment of the bioactivity of antibodies against beta-amyloid peptide in vitro and in vivo.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

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Modulation of Alzheimer's pathology by cerebro-ventricular grafting of hybridoma cells expressing antibodies against Abeta in vivo.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Intranasal administration of interferon beta bypasses the blood-brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy for multiple sclerosis

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

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1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

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1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

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Pharmacokinetics of substrate uptake and distribution in murine brain after nasal instillation

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

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Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Passive immunization against beta-amyloid peptide protects central nervous system (CNS) neurons from increased vulnerability associated with an Alzheimer's disease-causing mutation.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Abeta peptide immunization restores blood-brain barrier integrity in Alzheimer disease.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Beta-amyloid immunotherapy prevents synaptic degeneration in a mouse model of Alzheimer's disease.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Insights into the mechanisms of action of anti-Abeta antibodies in Alzheimer's disease mouse models.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Immunotherapy reduces vascular amyloid-beta in PDAPP mice.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Intranasal insulin improves cognition and modulates beta-amyloid in early AD.

1 reference

https://api.crossref.org/works/10.1371%2FJOURNAL.PONE.0018296

21 January 2018

Evaluation of the safety and immunogenicity of synthetic A 42 (AN1792) in patients with AD

1 reference

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1 reference

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27 November 2018

Non-Fc-mediated mechanisms are involved in clearance of amyloid-beta in vivo by immunotherapy.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071717

27 November 2018

Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3071717

27 November 2018

The binding constant for amyloid Abeta40 peptide interaction with human serum albumin

1 reference

https://pubmed.ncbi.nlm.nih.gov/21483675

12 December 2020

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1 reference

https://pubmed.ncbi.nlm.nih.gov/21483675

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1371/JOURNAL.PONE.0018296

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

2011PLoSO...618296C

0 references

OpenCitations bibliographic resource ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PMC publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

PubMed publication ID

1 reference

Consolidated OpenCitations Corpus – April 2017

OpenCitations bibliographic resource ID

ResearchGate publication ID

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