(Q27548560)

Ureohydrolase domain superfamily

1 reference

Histone deacetylase, subgroup

1 reference

inferred from protein domain or family

histone deacetylases

1 reference

based on heuristic

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

histone deacetylase activity

Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3

7 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

16 July 2018

A conserved motif common to the histone acetyltransferase Esa1 and the histone deacetylase Rpd3.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

16 July 2018

Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

16 July 2018

HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

16 July 2018

16 July 2018

A conserved motif common to the histone acetyltransferase Esa1 and the histone deacetylase Rpd3.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

transcription corepressor activity

hydrolase activity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

1 reference

9 May 2019

NAD-dependent histone deacetylase activity (H3-K14 specific)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

1 reference

9 May 2019

protein binding

10 references

9 May 2019

Raf60, a novel component of the Rpd3 histone deacetylase complex required for Rpd3 activity in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Eaf5/7/3 form a functionally independent NuA4 submodule linked to RNA polymerase II-coupled nucleosome recycling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

The yeast Snt2 protein coordinates the transcriptional response to hydrogen peroxide-mediated oxidative stress

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Identification of two CyP-40-like cyclophilins in Saccharomyces cerevisiae, one of which is required for normal growth

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Ssn6-Tup1 interacts with class I histone deacetylases required for repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Analyzing chromatin remodeling complexes using shotgun proteomics and normalized spectral abundance factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Defining the budding yeast chromatin‐associated interactome

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Tup1-Ssn6 interacts with multiple class I histone deacetylases in vivo.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

The MAPK Hog1 recruits Rpd3 histone deacetylase to activate osmoresponsive genes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

histone deacetylase activity

Histone deacetylase activity of Rpd3 is important for transcriptional repression in vivo

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

A conserved motif common to the histone acetyltransferase Esa1 and the histone deacetylase Rpd3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

9 May 2019

A conserved motif common to the histone acetyltransferase Esa1 and the histone deacetylase Rpd3.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

IBA

cell component

Rpd3L complex

3 references

10 September 2018

Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

10 September 2018

Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

10 September 2018

Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

nuclear periphery

1 reference

9 May 2019

Cmr1/WDR76 defines a nuclear genotoxic stress body linking genome integrity and protein quality control

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

Sin3-type complex

1 reference

16 July 2018

A Large Protein Complex Containing the Yeast Sin3p and Rpd3p Transcriptional Regulators

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

nucleus

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

1 reference

9 May 2019

cytoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

1 reference

9 May 2019

histone deacetylase complex

1 reference

16 July 2018

HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

Rpd3L complex

Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

Rpd3L-Expanded complex

1 reference

9 May 2019

Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

Snt2C complex

1 reference

9 May 2019

Chromatin Central: towards the comparative proteome by accurate mapping of the yeast proteomic environment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

transfer RNA gene-mediated silencing

biological process

1 reference

9 May 2019

Silencing near tRNA genes is nucleosome-mediated and distinct from boundary element function

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

histone deacetylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

1 reference

9 May 2019

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

1 reference

16 July 2018

transcription elongation from RNA polymerase II promoter

1 reference

9 May 2019

Histone H3K4 and K36 methylation, Chd1 and Rpd3S oppose the functions of Saccharomyces cerevisiae Spt4-Spt5 in transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

regulation of transcription involved in G2/M transition of mitotic cell cycle

1 reference

9 May 2019

Activation of the G2/M-specific gene CLB2 requires multiple cell cycle signals

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

positive regulation of macroautophagy

1 reference

9 May 2019

Function and molecular mechanism of acetylation in autophagy regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

regulation of DNA-dependent DNA replication initiation

Genome-wide replication profiles indicate an expansive role for Rpd3L in regulating replication initiation timing or efficiency, and reveal genomic loci of Rpd3 function in Saccharomyces cerevisiae

4 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Histone acetylation regulates the time of replication origin firing

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

The Rpd3-Sin3 histone deacetylase regulates replication timing and enables intra-S origin control in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

The Rpd3-Sin3 histone deacetylase regulates replication timing and enables intra-S origin control in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

protein localization to nucleolar rDNA repeats

1 reference

9 May 2019

Nutrient starvation promotes condensin loading to maintain rDNA stability

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

1 reference

16 July 2018

histone H4 deacetylation

negative regulation of transcription by RNA polymerase II

2 references

Ssn6-Tup1 interacts with class I histone deacetylases required for repression

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

H4 acetylation does not replace H3 acetylation in chromatin remodelling and transcription activation of Adr1-dependent genes.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

The Rpd3L HDAC complex is essential for the heat stress response in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

The unfolded protein response represses differentiation through the RPD3-SIN3 histone deacetylase

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Transcriptional regulation by Pho23 modulates the frequency of autophagosome formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

The roles of the catalytic and noncatalytic activities of Rpd3L and Rpd3S in the regulation of gene transcription in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Ssn6-Tup1 interacts with class I histone deacetylases required for repression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

histone H3 deacetylation

1 reference

16 July 2018

HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

positive regulation of transcription by RNA polymerase II

Direct role for the Rpd3 complex in transcriptional induction of the anaerobic DAN/TIR genes in yeast

7 references

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

16 July 2018

Histone deacetylases RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

16 July 2018

Regulation of the HAP1 gene involves positive actions of histone deacetylases

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

16 July 2018

Redundant mechanisms are used by Ssn6-Tup1 in repressing chromosomal gene transcription in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

16 July 2018

The Rpd3L HDAC complex is essential for the heat stress response in yeast.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

16 July 2018

Direct role for the Rpd3 complex in transcriptional induction of the anaerobic DAN/TIR genes in yeast

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

16 July 2018

Histone deacetylases RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P32561&geneProductId=UniProtKB:P32561

regulation of transcription involved in G1/S transition of mitotic cell cycle

negative regulation of silent mating-type cassette heterochromatin assembly

3 references

9 May 2019

Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

negative regulation of reciprocal meiotic recombination

1 reference

9 May 2019

The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

negative regulation of ribosomal DNA heterochromatin assembly

3 references

9 May 2019

A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Modulation of life-span by histone deacetylase genes in Saccharomyces cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

negative regulation of transcription involved in meiotic cell cycle

1 reference

9 May 2019

Interplay between chromatin and trans-acting factors on the IME2 promoter upon induction of the gene at the onset of meiosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

chromatin organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

1 reference

9 May 2019

positive regulation of transcription by RNA polymerase II

The Rpd3L HDAC complex is essential for the heat stress response in yeast.

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Regulation of the HAP1 gene involves positive actions of histone deacetylases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Histone deacetylases RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Direct role for the Rpd3 complex in transcriptional induction of the anaerobic DAN/TIR genes in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Redundant mechanisms are used by Ssn6-Tup1 in repressing chromosomal gene transcription in Saccharomyces cerevisiae

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Direct role for the Rpd3 complex in transcriptional induction of the anaerobic DAN/TIR genes in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Histone deacetylases RPD3 and HOS2 regulate the transcriptional activation of DNA damage-inducible genes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

IBA

histone H4 deacetylation

Transcriptional repression by UME6 involves deacetylation of lysine 5 of histone H4 by RPD3

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P32561

Histone deacetylase domain

IBA

has part(s)

1 reference

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference