(Q27550444)

English

Derlin YBR201W

fungal protein found in Saccharomyces cerevisiae S288c

DER1
derlin
YBR201W

In more languages

Statements

1 reference

25 May 2022

UniProt protein ID

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P38307

membrane protein

1 reference

based on heuristic

inferred from GOA cell component → membrane

Endoplasmic Reticular Retrotranslocon

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

molecular function

misfolded protein binding

determination method

1 reference

9 May 2019

Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

protein binding

determination method

6 references

9 May 2019

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

9 May 2019

High-quality binary protein interaction map of the yeast interactome network

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

9 May 2019

The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

9 May 2019

Membrane-bound Ubx2 recruits Cdc48 to ubiquitin ligases and their substrates to ensure efficient ER-associated protein degradation

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

9 May 2019

The ER-associated degradation component Der1p and its homolog Dfm1p are contained in complexes with distinct cofactors of the ATPase Cdc48p

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

9 May 2019

Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

peptidase activity

determination method

1 reference

9 May 2019

Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

Hrd1p ubiquitin ligase ERAD-L complex

determination method

1 reference

9 May 2019

Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

endoplasmic reticulum

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

integral component of membrane

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

biological process

ubiquitin-dependent ERAD pathway

determination method

3 references

9 May 2019

The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

9 May 2019

N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

9 May 2019

Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

protein transport

determination method

1 reference

9 May 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

retrograde protein transport, ER to cytosol

determination method

1 reference

9 May 2019

Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

misfolded protein transport

determination method

1 reference

9 May 2019

Der1 promotes movement of misfolded proteins through the endoplasmic reticulum membrane

Saccharomyces Genome Database ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

protein quality control for misfolded or incompletely synthesized proteins

determination method

1 reference

9 May 2019

Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38307

determination method

Identifiers

RefSeq protein ID

1 reference

20 March 2022

UniProt protein ID

1 reference

25 May 2022

UniProt protein ID

Ensembl protein ID

1 reference

ensembl Release 106

Ensembl protein ID

Saccharomyces Genome Database ID

1 reference

20 March 2022

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

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