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Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p
scientific article
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instance of
scholarly article
1 reference
stated in
PubMed
PubMed ID
21074049
retrieved
1 December 2016
title
Retrotranslocation of a misfolded luminal ER protein by the ubiquitin-ligase Hrd1p
(English)
1 reference
stated in
PubMed
PubMed ID
21074049
retrieved
1 December 2016
main subject
AAA family ATPase CDC48 YDL126C
1 reference
stated in
GOA release 2020-03-11
Yos9p YDR057W
1 reference
stated in
GOA release 2020-03-11
Derlin YBR201W
1 reference
stated in
GOA release 2020-03-11
Usa1p YML029W
1 reference
stated in
GOA release 2020-03-11
Ubx2p YML013W
1 reference
stated in
GOA release 2020-03-11
Ubiquitin ligase complex subunit HRD3 YLR207W
1 reference
stated in
GOA release 2020-03-11
E3 ubiquitin-protein ligase HRD1 YOL013C
1 reference
stated in
GOA release 2020-03-11
Carboxypeptidase C PRC1 YMR297W
1 reference
stated in
GOA release 2020-03-11
author
Tom Rapoport
series ordinal
3
object named as
Tom A Rapoport
0 references
Pedro Carvalho
object named as
Pedro Carvalho
series ordinal
1
0 references
author name string
Ann Marie Stanley
series ordinal
2
0 references
language of work or name
English
0 references
publication date
12 November 2010
0 references
published in
Cell
1 reference
stated in
PubMed
PubMed ID
21074049
retrieved
1 December 2016
volume
143
0 references
issue
4
0 references
page(s)
579-91
0 references
cites work
Usa1 functions as a scaffold of the HRD-ubiquitin ligase.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
Sec61p is part of the endoplasmic reticulum-associated degradation machinery
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
Htm1 protein generates the N-glycan signal for glycoprotein degradation in the endoplasmic reticulum
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
Defining the glycan destruction signal for endoplasmic reticulum-associated degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
The Hrd1p ligase complex forms a linchpin between ER-lumenal substrate selection and Cdc48p recruitment
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
Yos9 protein is essential for degradation of misfolded glycoproteins and may function as lectin in ERAD.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
Yos9p detects and targets misfolded glycoproteins for ER-associated degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
Exploration of the topological requirements of ERAD identifies Yos9p as a lectin sensor of misfolded glycoproteins in the ER lumen
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
A membrane protein required for dislocation of misfolded proteins from the ER
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
Protein dislocation from the ER requires polyubiquitination and the AAA-ATPase Cdc48.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
AAA-ATPase p97/Cdc48p, a cytosolic chaperone required for endoplasmic reticulum-associated protein degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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20 March 2017
HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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20 March 2017
Mobilization of processed, membrane-tethered SPT23 transcription factor by CDC48(UFD1/NPL4), a ubiquitin-selective chaperone
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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20 March 2017
A conserved ubiquitin ligase of the nuclear envelope/endoplasmic reticulum that functions in both ER-associated and Matalpha2 repressor degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
The engagement of Sec61p in the ER dislocation process
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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20 March 2017
Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
retrieved
20 March 2017
Sec61p mediates export of a misfolded secretory protein from the endoplasmic reticulum to the cytosol for degradation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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20 March 2017
Sec61-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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20 March 2017
Der1, a novel protein specifically required for endoplasmic reticulum degradation in yeast
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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20 March 2017
An expanded eukaryotic genetic code
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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20 March 2017
Diverse functions with a common regulator: ubiquitin takes command of an AAA ATPase
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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20 March 2017
ERAD substrate recognition in budding yeast
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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29 September 2017
Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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29 September 2017
The E3 ubiquitin ligases Hrd1 and gp78 bind to and promote cholera toxin retro-translocation
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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29 September 2017
Intrinsic conformational determinants signal protein misfolding to the Hrd1/Htm1 endoplasmic reticulum-associated degradation system
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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29 September 2017
The ubiquitylation machinery of the endoplasmic reticulum
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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29 September 2017
Sec61p is required for ERAD-L: genetic dissection of the translocation and ERAD-L functions of Sec61P using novel derivatives of CPY.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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29 September 2017
A lipid-based model for the creation of an escape hatch from the endoplasmic reticulum
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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29 September 2017
Ubiquitination of MHC class I heavy chains is essential for dislocation by human cytomegalovirus-encoded US2 but not US11.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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29 September 2017
Role of the ubiquitin-selective CDC48(UFD1/NPL4 )chaperone (segregase) in ERAD of OLE1 and other substrates
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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29 September 2017
Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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29 September 2017
The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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29 September 2017
Signal sequence recognition in posttranslational protein transport across the yeast ER membrane.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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2 June 2018
An improved system for the generation and analysis of mutant proteins containing unnatural amino acids in Saccharomyces cerevisiae.
1 reference
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PubMed Central
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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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27 November 2018
A complex of Yos9p and the HRD ligase integrates endoplasmic reticulum quality control into the degradation machinery.
1 reference
stated in
PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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27 November 2018
Use of modular substrates demonstrates mechanistic diversity and reveals differences in chaperone requirement of ERAD.
1 reference
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PubMed Central
reference URL
https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3026631
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27 November 2018
Genetic interactions of Hrd3p and Der3p/Hrd1p with Sec61p suggest a retro-translocation complex mediating protein transport for ER degradation
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21074049
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21074049
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin
1 reference
stated in
PubMed
reference URL
https://pubmed.ncbi.nlm.nih.gov/21074049
retrieved
12 December 2020
based on heuristic
inferred from PubMed ID database lookup
Identifiers
DOI
10.1016/J.CELL.2010.10.028
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4331023
OpenCitations bibliographic resource ID
4331023
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4331023
PMCID
3026631
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4331023
PubMed ID
21074049
1 reference
stated in
Consolidated OpenCitations Corpus – April 2017
OpenCitations bibliographic resource ID
4331023
ResearchGate publication ID
47789481
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