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Translation initiation factor eIF5B YAL035W
fungal protein found in Saccharomyces cerevisiae S288c
YAL035W
FUN12
translation initiation factor eIF5B
In more languages
edit
Statements
instance of
protein
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P39730
subclass of
protein
1 reference
stated in
UniProt
retrieved
19 January 2017
UniProt protein ID
P39730
part of
translation initiation factor IF- 2
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P39730
Translation protein, beta-barrel domain superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P39730
Translation initiation factor IF-2, domain 3 superfamily
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P39730
P-loop containing nucleoside triphosphate hydrolase
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P39730
Translation elongation factor EFTu-like, domain 2, protein family
1 reference
based on heuristic
inferred from protein domain or family
Translation initiation factor IF- 2, domain 3, protein family
1 reference
based on heuristic
inferred from protein domain or family
Transcription factor, GTP-binding domain, protein family
1 reference
based on heuristic
inferred from protein domain or family
Small GTP-binding protein domain family
1 reference
based on heuristic
inferred from protein domain or family
found in taxon
Saccharomyces cerevisiae S288c
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P39730
encoded by
FUN12
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P39730
molecular function
GTPase activity
determination method
IMP
IEA
IDA
3 references
retrieved
9 May 2019
stated in
Initiation factor eIF5B catalyzes second GTP-dependent step in eukaryotic translation initiation
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IMP
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IEA
retrieved
9 May 2019
stated in
rRNA suppressor of a eukaryotic translation initiation factor 5B/initiation factor 2 mutant reveals a binding site for translational GTPases on the small ribosomal subunit.
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IDA
metal ion binding
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P39730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IEA
hydrolase activity
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P39730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IEA
nucleotide binding
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P39730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IEA
translation initiation factor activity
determination method
IEA
IDA
3 references
retrieved
5 June 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P39730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P39730&geneProductId=UniProtKB:P39730
determination method
IEA
retrieved
5 June 2018
stated in
Development and characterization of a reconstituted yeast translation initiation system.
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P39730&geneProductId=UniProtKB:P39730
determination method
IDA
retrieved
5 June 2018
stated in
Promotion of met-tRNAiMet binding to ribosomes by yIF2, a bacterial IF2 homolog in yeast
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P39730&geneProductId=UniProtKB:P39730
determination method
IDA
GTP binding
determination method
IEA
IDA
3 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P39730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IEA
retrieved
9 May 2019
stated in
Structural integrity of {alpha}-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability.
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IDA
translation initiation factor binding
determination method
IDA
1 reference
retrieved
9 May 2019
stated in
Physical and functional interaction between the eukaryotic orthologs of prokaryotic translation initiation factors IF1 and IF2
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IDA
ribosome binding
determination method
IDA
1 reference
retrieved
9 May 2019
stated in
Structural integrity of {alpha}-helix H12 in translation initiation factor eIF5B is critical for 80S complex stability.
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IDA
protein binding
determination method
IPI
2 references
retrieved
5 June 2018
stated in
Proteome survey reveals modularity of the yeast cell machinery
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P39730&geneProductId=UniProtKB:P39730
determination method
IPI
retrieved
5 June 2018
stated in
High-definition macromolecular composition of yeast RNA-processing complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P39730&geneProductId=UniProtKB:P39730
determination method
IPI
translation initiation factor activity
determination method
IBA
IDA
IEA
4 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P39730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IEA
retrieved
9 May 2019
stated in
Development and characterization of a reconstituted yeast translation initiation system.
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IDA
retrieved
9 May 2019
stated in
Promotion of met-tRNAiMet binding to ribosomes by yIF2, a bacterial IF2 homolog in yeast
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IBA
cell component
cytosolic small ribosomal subunit
determination method
IDA
1 reference
retrieved
9 May 2019
stated in
Promotion of met-tRNAiMet binding to ribosomes by yIF2, a bacterial IF2 homolog in yeast
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IDA
eukaryotic 48S preinitiation complex
determination method
IDA
1 reference
retrieved
9 May 2019
stated in
Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining.
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IDA
cytoplasm
determination method
IEA
1 reference
retrieved
7 November 2018
stated in
GOA
curator
UniProt
UniProt protein ID
P39730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P39730&geneProductId=UniProtKB:P39730
determination method
IEA
cytoplasmic stress granule
determination method
IDA
1 reference
retrieved
9 May 2019
stated in
ATPase-Modulated Stress Granules Contain a Diverse Proteome and Substructure.
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IDA
cytoplasm
determination method
HDA
IEA
2 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P39730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IEA
retrieved
9 May 2019
stated in
Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
HDA
mitochondrion
determination method
HDA
2 references
retrieved
9 May 2019
stated in
Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
HDA
retrieved
9 May 2019
stated in
The proteome of Saccharomyces cerevisiae mitochondria
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
HDA
cytosol
determination method
HDA
1 reference
retrieved
9 May 2019
stated in
One library to make them all: streamlining the creation of yeast libraries via a SWAp-Tag strategy
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
HDA
biological process
translational initiation
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P39730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IEA
formation of cytoplasmic translation initiation complex
determination method
IMP
IDA
2 references
retrieved
9 May 2019
stated in
Coupled release of eukaryotic translation initiation factors 5B and 1A from 80S ribosomes following subunit joining.
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IMP
retrieved
9 May 2019
stated in
Development and characterization of a reconstituted yeast translation initiation system.
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IDA
regulation of translational initiation
determination method
IMP
1 reference
retrieved
9 May 2019
stated in
Uncoupling of initiation factor eIF5B/IF2 GTPase and translational activities by mutations that lower ribosome affinity
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IMP
protein biosynthesis
determination method
IEA
1 reference
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P39730
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IEA
maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
determination method
IMP
1 reference
retrieved
9 May 2019
stated in
Proofreading of pre-40S ribosome maturation by a translation initiation factor and 60S subunits
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IMP
ribosome assembly
determination method
IMP
1 reference
retrieved
9 May 2019
stated in
A translation-like cycle is a quality control checkpoint for maturing 40S ribosome subunits
GOA
curator
SGD
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P39730
determination method
IMP
has part(s)
translation elongation factor EFTu-like, domain 2
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P39730
small GTP-binding protein domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P39730
Translation initiation factor IF- 2, domain 3
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P39730
transcription factor, GTP-binding domain
1 reference
stated in
InterPro Release 71.0
reference URL
http://www.ebi.ac.uk/interpro/protein/P39730
Identifiers
RefSeq protein ID
NP_009365
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
851196
UniProt protein ID
P39730
1 reference
stated in
UniProt
retrieved
25 May 2022
UniProt protein ID
P39730
Ensembl protein ID
YAL035W
1 reference
stated in
ensembl Release 106
Ensembl protein ID
YAL035W
Saccharomyces Genome Database ID
S000000033
1 reference
stated in
NCBI Gene
retrieved
20 March 2022
Entrez Gene ID
851196
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