(Q27553073)

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53064

Plus-3 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Saccharomyces cerevisiae S288c

1 reference

25 May 2022

1 reference

25 May 2022

1 reference

9 May 2019

Leo1 Subunit of the Yeast Paf1 Complex Binds RNA and Contributes to Complex Recruitment*

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

DNA binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

1 reference

9 May 2019

RNA polymerase II C-terminal domain phosphoserine binding

1 reference

27 February 2018

Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53064&geneProductId=UniProtKB:P53064

protein binding

6 references

9 May 2019

Mpk1 MAPK association with the Paf1 complex blocks Sen1-mediated premature transcription termination.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

9 May 2019

RNA polymerase II elongation factors of Saccharomyces cerevisiae: a targeted proteomics approach

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

9 May 2019

Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

9 May 2019

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

9 May 2019

Proteome survey reveals modularity of the yeast cell machinery

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

9 May 2019

Direct Bre1-Paf1 complex interactions and RING finger-independent Bre1-Rad6 interactions mediate histone H2B ubiquitylation in yeast

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

cell component

nucleoplasm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

1 reference

9 May 2019

Cdc73/Paf1 complex

Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex

3 references

27 February 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53064&geneProductId=UniProtKB:P53064

27 February 2018

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53064&geneProductId=UniProtKB:P53064

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53064&geneProductId=UniProtKB:P53064

27 February 2018

Cdc73/Paf1 complex

Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

8 April 2019

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

8 April 2019

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

IBA

Cdc73/Paf1 complex

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

9 May 2019

Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

IBA

biological process

histone modification

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

1 reference

8 April 2019

recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex

1 reference

9 May 2019

Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53064&geneProductId=UniProtKB:P53064

1 reference

27 February 2018

positive regulation of transcription elongation from RNA polymerase I promoter

1 reference

9 May 2019

The RNA polymerase-associated factor 1 complex (Paf1C) directly increases the elongation rate of RNA polymerase I and is required for efficient regulation of rRNA synthesis.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

snoRNA transcription by RNA polymerase II

1 reference

9 May 2019

A Requirement for the Saccharomyces cerevisiae Paf1 complex in snoRNA 3' end formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Ctr9, Rtf1, and Leo1 are components of the Paf1/RNA polymerase II complex

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

positive regulation of transcription elongation from RNA polymerase II promoter

1 reference

9 May 2019

Molecular evidence indicating that the yeast PAF complex is required for transcription elongation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

global genome nucleotide-excision repair

1 reference

9 May 2019

Diverse roles of RNA polymerase II-associated factor 1 complex in different subpathways of nucleotide excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

DNA-templated transcription, termination

1 reference

9 May 2019

Effects of the Paf1 complex and histone modifications on snoRNA 3'-end formation reveal broad and locus-specific regulation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

positive regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues

1 reference

9 May 2019

Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

regulation of transcription-coupled nucleotide-excision repair

1 reference

9 May 2019

Diverse roles of RNA polymerase II-associated factor 1 complex in different subpathways of nucleotide excision repair

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

negative regulation of transcription by RNA polymerase II

1 reference

9 May 2019

Effectors of lysine 4 methylation of histone H3 in Saccharomyces cerevisiae are negative regulators of PHO5 and GAL1-10.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

regulation of phosphorylation of RNA polymerase II C-terminal domain serine 2 residues

1 reference

9 May 2019

The Paf1 complex has functions independent of actively transcribing RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

regulation of histone H2B conserved C-terminal lysine ubiquitination

sno(s)RNA 3'-end processing

1 reference

9 May 2019

A Requirement for the Saccharomyces cerevisiae Paf1 complex in snoRNA 3' end formation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

regulation of histone H3-K79 methylation

1 reference

9 May 2019

The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

transcription elongation from RNA polymerase II promoter

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

8 April 2019

The Paf1 complex physically and functionally associates with transcription elongation factors in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

8 April 2019

mRNA 3'-end processing

1 reference

9 May 2019

The Paf1 complex has functions independent of actively transcribing RNA polymerase II.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

regulation of histone H3-K4 methylation

4 references

9 May 2019

Effectors of lysine 4 methylation of histone H3 in Saccharomyces cerevisiae are negative regulators of PHO5 and GAL1-10.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

9 May 2019

The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

9 May 2019

The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

9 May 2019

The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P53064

regulation of histone H2B ubiquitination

regulation of transcription, DNA-templated

http://www.ebi.ac.uk/QuickGO/annotations?protein=P53064&geneProductId=UniProtKB:P53064

1 reference

27 February 2018

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P53064

Identifiers

1 reference

20 March 2022

1 reference

25 May 2022

1 reference