(Q27640105)

1

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Ciarán N Cronin

2

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Duncan E McRee

3

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Christian G Nelson

5

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Nikola P Pavletich

6

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Joe Rogers

7

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Bi-Ching Sang

8

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Daniel N Scheibe

9

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Ronald V Swanson

10

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Devon A Thompson

Protein kinases--the major drug targets of the twenty-first century?

11

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language of work or name

English

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publication date

December 2002

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published in

Structure

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volume

10

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page(s)

1659-67

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issue

12

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cites work

1 reference

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7 January 2021

Oncogenic kinase signalling

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7 January 2021

The Sequence of the Human Genome

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7 January 2021

Eph receptors and ephrin ligands: embryogenesis to tumorigenesis

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7 January 2021

cDNA cloning and characterization of eck, an epithelial cell receptor protein-tyrosine kinase in the eph/elk family of protein kinases

1 reference

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7 January 2021

B61 is a ligand for the ECK receptor protein-tyrosine kinase

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7 January 2021

Characterization of B61, the ligand for the Eck receptor protein-tyrosine kinase

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7 January 2021

The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization.

1 reference

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7 January 2021

Estrogen and Myc negatively regulate expression of the EphA2 tyrosine kinase

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7 January 2021

Overexpression of the EphA2 tyrosine kinase in prostate cancer.

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7 January 2021

Molecular classification of cutaneous malignant melanoma by gene expression profiling

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7 January 2021

Activation of EphA2 kinase suppresses integrin function and causes focal-adhesion-kinase dephosphorylation

1 reference

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7 January 2021

EphrinA1-induced cytoskeletal re-organization requires FAK and p130(cas).

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7 January 2021

Focal adhesion kinase as a marker of invasive potential in differentiated human thyroid cancer

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7 January 2021

Biochemical signals and biological responses elicited by the focal adhesion kinase

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7 January 2021

The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix bundle that binds paxillin

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7 January 2021

Signaling through focal adhesion kinase

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7 January 2021

Requirement for focal adhesion kinase in tumor cell adhesion

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7 January 2021

Overexpression of the focal adhesion kinase (p125FAK) in the vascular smooth muscle cells of intimal hyperplasia.

1 reference

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7 January 2021

cDNA cloning, expression, subcellular localization, and chromosomal assignment of mammalian aurora homologues, aurora-related kinase (ARK) 1 and 2

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7 January 2021

A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers

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7 January 2021

Mitotic kinases as regulators of cell division and its checkpoints

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7 January 2021

The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis.

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7 January 2021

Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation

1 reference

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7 January 2021

A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines

1 reference

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7 January 2021

Association of centrosomal kinase STK15/BTAK mRNA expression with chromosomal instability in human breast cancers

1 reference

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7 January 2021

Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle

1 reference

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7 January 2021

Design of high-throughput methods of protein production for structural biology

1 reference

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7 January 2021

High-throughput protein crystallization

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7 January 2021

Active and inactive protein kinases: structural basis for regulation

1 reference

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7 January 2021

The conformational plasticity of protein kinases

1 reference

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7 January 2021

Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1 reference

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7 January 2021

Structural basis of cyclin-dependent kinase activation by phosphorylation

1 reference

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7 January 2021

The mitotic serine/threonine kinase Aurora2/AIK is regulated by phosphorylation and degradation

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7 January 2021

Structure of GSK3beta reveals a primed phosphorylation mechanism

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7 January 2021

The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation

1 reference

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7 January 2021

Crystal structure of the catalytic subunit of protein kinase CK2 from Zea mays at 2.1 A resolution.

1 reference

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7 January 2021

Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes

1 reference

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7 January 2021

CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis

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7 January 2021

Structure of the FGF receptor tyrosine kinase domain reveals a novel autoinhibitory mechanism

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7 January 2021

Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis

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7 January 2021

Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region

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7 January 2021

Chemical inhibitors of cyclin-dependent kinases: insights into design from X-ray crystallographic studies.

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7 January 2021

Structural basis of inhibitor selectivity in MAP kinases

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7 January 2021

Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

1 reference

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7 January 2021

Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug

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7 January 2021

XtalView/Xfit--A versatile program for manipulating atomic coordinates and electron density

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7 January 2021

Automated protein model building combined with iterative structure refinement

1 reference

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7 January 2021

10.1016/S0969-2126(02)00907-3

Identifiers

DOI

1 reference

Consolidated OpenCitations Corpus – April 2017

3537976

3537976

1 reference

Consolidated OpenCitations Corpus – April 2017

Consolidated OpenCitations Corpus – April 2017

1 reference