(Q27641233)

https://api.crossref.org/works/10.1016/S0022-2836(03)00399-1

1 January 2024

1 reference

https://api.crossref.org/works/10.1016/S0022-2836(03)00399-1

1 January 2024

4

Richard L Mackman

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author name string

Kyle Elrod

2

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Erik Verner

3

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Christine Luong

5

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Martin Sendzik

7

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Aleks Kolesnikov

10

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Vincent W-F Tai

11

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Darin Allen

14

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Bradley A. Katz

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12742021

1 January 2024

William D. Shrader

6

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1 January 2024

Jeffrey R. Spencer

8

1 reference

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1 January 2024

Paul A. Sprengeler

9

1 reference

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1 January 2024

Hon C. Hui

12

1 reference

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1 January 2024

J. Guy Breitenbucher

13

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A12742021

1 January 2024

James W. Janc

15

1 reference

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1 January 2024

language of work or name

English

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publication date

23 May 2003

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number of pages

28

1 reference

full work available at URL

inferred from page(s)

https://api.elsevier.com/content/article/PII:S0022283603003991?httpAccept=text/xml

1 reference

https://api.crossref.org/works/10.1016/S0022-2836(03)00399-1

https://api.elsevier.com/content/article/PII:S0022283603003991?httpAccept=text/plain

1 January 2024

1 reference

https://api.crossref.org/works/10.1016/S0022-2836(03)00399-1

Journal of Molecular Biology

1 January 2024

published in

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volume

329

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issue

1

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page(s)

93-120

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cites work

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Contribution of multicentered short hydrogen bond arrays to potency of active site-directed serine protease inhibitors

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Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa.

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Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets

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Exploiting subsite S1 of trypsin-like serine proteases for selectivity: potent and selective inhibitors of urokinase-type plasminogen activator

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Optimization of a screening lead for factor VIIa/TF.

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Development of potent and selective factor Xa inhibitors

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2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors

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Energy considerations show that low-barrier hydrogen bonds do not offer a catalytic advantage over ordinary hydrogen bonds

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Electrostatic origin of the catalytic power of enzymes and the role of preorganized active sites

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A very short hydrogen bond provides only moderate stabilization of an enzyme-inhibitor complex of citrate synthase

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alpha-Fluoro acid and alpha-fluoro amide analogs of acetyl-CoA as inhibitors of citrate synthase: effect of pKa matching on binding affinity and hydrogen bond length

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Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator

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Identifiers

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