(Q27641853)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

title

A novel mechanism of cyclooxygenase-2 inhibition involving interactions with Ser-530 and Tyr-385 (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

Prostaglandin-endoperoxide synthase 2

7 November 2019

main subject

1 reference

GOA release 2020-03-11

author

James R Kiefer

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

9

Lawrence J Marnett

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

author name string

Scott W Rowlinson

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Jeffery J Prusakiewicz

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Jennifer L Pawlitz

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Kevin R Kozak

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Amit S Kalgutkar

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

William C Stallings

7

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

Ravi G Kurumbail

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

language of work or name

English

0 references

publication date

18 August 2003

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

Journal of Biological Chemistry

7 November 2019

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

volume

278

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

issue

46

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

page(s)

45763-45769

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

Isolation and Structure of Two Prostaglandin Endoperoxides That Cause Platelet Aggregation

7 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Isolation and properties of intermediates in prostaglandin biosynthesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Cyclooxygenases: structural, cellular, and molecular biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Cyclooxygenase enzymes: catalysis and inhibition

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Prostaglandin synthase 2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

21 January 2018

Cyclooxygenases 1 and 2

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Flexibility of the NSAID binding site in the structure of human cyclooxygenase-2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

The productive conformation of arachidonic acid bound to prostaglandin synthase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Structural insights into the stereochemistry of the cyclooxygenase reaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Protein hydration observed by X-ray diffraction. Solvation properties of penicillopepsin and neuraminidase crystal structures.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Inhibitor-induced changes in the intrinsic fluorescence of human cyclooxygenase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Differential binding mode of diverse cyclooxygenase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Selective inhibition of cyclooxygenase-1 and -2 using intact insect cell assays

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Structural analysis of NSAID binding by prostaglandin H2 synthase: time-dependent and time-independent inhibitors elicit identical enzyme conformations

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

Molecular model of the interaction between nimesulide and human cyclooxygenase-2.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M305481200

21 January 2018

Identifiers

DOI

10.1074/JBC.M305481200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12925531%20AND%20SRC:MED&resulttype=core&format=json

7 November 2019

1 reference