(Q27643866)

English

Crystal Structure of the T877A Human Androgen Receptor Ligand-binding Domain Complexed to Cyproterone Acetate Provides Insight for Ligand-induced Conformational Changes and Structure-based Drug Design

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scholarly article

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Crystal Structure of the T877A Human Androgen Receptor Ligand-binding Domain Complexed to Cyproterone Acetate Provides Insight for Ligand-induced Conformational Changes and Structure-based Drug Design (English)

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crystal structure

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1 reference

based on heuristic

inferred from title

5

object named as

James T Dalton

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author name string

Casey E Bohl

1

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Zengru Wu

2

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Duane D Miller

3

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Charles E Bell

4

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language of work or name

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publication date

4 May 2007

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Journal of Biological Chemistry

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282

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18

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13648-55

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Structural basis for antagonism and resistance of bicalutamide in prostate cancer

1 reference

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Crystallographic structures of the ligand-binding domains of the androgen receptor and its T877A mutant complexed with the natural agonist dihydrotestosterone

1 reference

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Structural evidence for ligand specificity in the binding domain of the human androgen receptor. Implications for pathogenic gene mutations

1 reference

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1 reference

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1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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1 reference

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In vitro and in vivo structure-activity relationships of novel androgen receptor ligands with multiple substituents in the B-ring

1 reference

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The para substituent of S-3-(phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamides is a major structural determinant of in vivo disposition and activity of selective androgen receptor modulators

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1 reference

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A ligand-based approach to identify quantitative structure-activity relationships for the androgen receptor

1 reference

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Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators

1 reference

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Glucocorticoid Receptor Antagonism by Cyproterone Acetate and RU486

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Key structural features of nonsteroidal ligands for binding and activation of the androgen receptor.

1 reference

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Novel nonsteroidal ligands with high binding affinity and potent functional activity for the androgen receptor.

1 reference

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Discovery of nonsteroidal androgens

1 reference

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Codon 877 mutation in the androgen receptor gene in advanced prostate cancer: relation to antiandrogen withdrawal syndrome

1 reference

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1 reference

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1 reference

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Homology modeling using multiple molecular dynamics simulations and docking studies of the human androgen receptor ligand binding domain bound to testosterone and nonsteroidal ligands.

1 reference

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Three-dimensional structure-activity relationships of nonsteroidal ligands in complex with androgen receptor ligand-binding domain.

1 reference

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1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Specific recognition of androgens by their nuclear receptor. A structure-function study

1 reference

https://pubmed.ncbi.nlm.nih.gov/17311914

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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