(Q27643993)

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Stephanie Moquin

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Pamela J. Bjorkman

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An-Suei Yang

An-Suei Yang

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Tongqing Zhou

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Myron S. Cohen

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Myron S Cohen

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Michel C. Nussenzweig

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John R. Mascola

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James C Mullikin

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Quentin J Sattentau

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Robert Bailer

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Robert T Bailer

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Anqi Zheng

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Mark Connors

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Mark Connors

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author name string

Lei Chen

3

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Xueling Wu

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Rui Kong

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Hung-Pin Peng

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Davide Corti

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Anthony P West

Structural insights on the role of antibodies in HIV-1 vaccine and therapy

47

0 references

language of work or name

English

0 references

publication date

4 June 2015

0 references

published in

Cell

0 references

volume

161

0 references

issue

6

0 references

page(s)

1280-92

0 references

cites work

1 reference

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Crystal Structure of a Soluble Cleaved HIV-1 Envelope Trimer

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Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

20 March 2017

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Restricting HIV-1 pathways for escape using rationally designed anti–HIV-1 antibodies

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Supersite of immune vulnerability on the glycosylated face of HIV-1 envelope glycoprotein gp120

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Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization

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Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

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Rational HIV Immunogen Design to Target Specific Germline B Cell Receptors

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Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

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Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

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Increasing the potency and breadth of an HIV antibody by using structure-based rational design

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A Potent and Broad Neutralizing Antibody Recognizes and Penetrates the HIV Glycan Shield

20 March 2017

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Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

20 March 2017

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Sequence and Structural Convergence of Broad and Potent HIV Antibodies That Mimic CD4 Binding

20 March 2017

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A new clustering of antibody CDR loop conformations

20 March 2017

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Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

20 March 2017

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PHENIX: a comprehensive Python-based system for macromolecular structure solution

20 March 2017

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Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

20 March 2017

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Structural definition of a conserved neutralization epitope on HIV-1 gp120

20 March 2017

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Antibody domain exchange is an immunological solution to carbohydrate cluster recognition

20 March 2017

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Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody

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Crystal structure of a camel single-domain VH antibody fragment in complex with lysozyme

20 March 2017

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Three-dimensional structures of the free and the antigen-complexed Fab from monoclonal anti-lysozyme antibody D44.1

20 March 2017

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Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex

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Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

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Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41

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Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

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Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo

29 September 2017

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Prevalence of broadly neutralizing antibody responses during chronic HIV-1 infection

29 September 2017

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De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts

29 September 2017

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Engineering HIV envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies

29 September 2017

1 reference

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Somatic Populations of PGT135-137 HIV-1-Neutralizing Antibodies Identified by 454 Pyrosequencing and Bioinformatics

29 September 2017

1 reference

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Structural basis for germ-line gene usage of a potent class of antibodies targeting the CD4-binding site of HIV-1 gp120.

29 September 2017

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The development of CD4 binding site antibodies during HIV-1 infection

29 September 2017

1 reference

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Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation

29 September 2017

1 reference

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A limited number of antibody specificities mediate broad and potent serum neutralization in selected HIV-1 infected individuals

29 September 2017

1 reference

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Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals

29 September 2017

1 reference

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A method for identification of HIV gp140 binding memory B cells in human blood

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683157

Measuring HIV neutralization in a luciferase reporter gene assay

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683157

Profiling the specificity of neutralizing antibodies in a large panel of plasmas from patients chronically infected with human immunodeficiency virus type 1 subtypes B and C.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683157

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683157

Broad HIV-1 neutralization mediated by CD4-binding site antibodies

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683157

Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683157

Free energy determinants of tertiary structure and the evaluation of protein models.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683157

Biological characterization of a simian immunodeficiency virus-like retrovirus (HTLV-IV): evidence for CD4-associated molecules required for infection.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683157

Crystal structure of an HIV-binding recombinant fragment of human CD4.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683157

Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683157

HIV infection of primate lymphocytes and conservation of the CD4 receptor

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4683157

10.1016/J.CELL.2015.05.007

2 June 2018

Identifiers

DOI

1 reference

3745454

3745454

1 reference

1 reference

1 reference