(Q27645269)

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Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu Zn superoxide dismutase

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scholarly article

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Molecular dynamics using atomic-resolution structure reveal structural fluctuations that may lead to polymerization of human Cu Zn superoxide dismutase (English)

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molecular dynamics simulation

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author name string

Richard W Strange

1

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Chin W Yong

2

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William Smith

3

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S Samar Hasnain

4

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language of work or name

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publication date

12 June 2007

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Proceedings of the National Academy of Sciences of the United States of America

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104

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24

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10040-4

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Solution structure of Apo Cu,Zn superoxide dismutase: role of metal ions in protein folding

1 reference

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20 March 2017

Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS

1 reference

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20 March 2017

The structure of holo and metal-deficient wild-type human Cu, Zn superoxide dismutase and its relevance to familial amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

20 March 2017

An alternative mechanism of bicarbonate-mediated peroxidation by copper-zinc superoxide dismutase: rates enhanced via proposed enzyme-associated peroxycarbonate intermediate

1 reference

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20 March 2017

Structure and dynamics of copper-free SOD: The protein before binding copper

1 reference

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20 March 2017

The solution structure of reduced dimeric copper zinc superoxide dismutase. The structural effects of dimerization

1 reference

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20 March 2017

Natural beta-sheet proteins use negative design to avoid edge-to-edge aggregation

1 reference

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20 March 2017

Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

20 March 2017

All-atom empirical potential for molecular modeling and dynamics studies of proteins

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

20 March 2017

Automated refinement of protein models

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

20 March 2017

A graphical user interface to the CCP4 program suite

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

20 March 2017

Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

20 March 2017

From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

20 March 2017

Folding of Cu/Zn superoxide dismutase suggests structural hotspots for gain of neurotoxic function in ALS: parallels to precursors in amyloid disease

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

29 September 2017

Posttranslational modifications in Cu,Zn-superoxide dismutase and mutations associated with amyotrophic lateral sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

29 September 2017

Common dynamical signatures of familial amyotrophic lateral sclerosis-associated structurally diverse Cu, Zn superoxide dismutase mutants

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

29 September 2017

Aberrantly increased hydrophobicity shared by mutants of Cu,Zn-superoxide dismutase in familial amyotrophic lateral sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

29 September 2017

Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

29 September 2017

Efficient rebuilding of protein structures.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

29 September 2017

Superoxide dismutase folding/unfolding pathway: role of the metal ions in modulating structural and dynamical features.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

29 September 2017

Common denominator of Cu/Zn superoxide dismutase mutants associated with amyotrophic lateral sclerosis: decreased stability of the apo state

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

29 September 2017

Decreased metallation and activity in subsets of mutant superoxide dismutases associated with familial amyotrophic lateral sclerosis.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

29 September 2017

Binding of buried structural water increases the flexibility of proteins

1 reference

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29 September 2017

Structural consequences of the familial amyotrophic lateral sclerosis SOD1 mutant His46Arg.

1 reference

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2 June 2018

Subunit asymmetry in the three-dimensional structure of a human CuZnSOD mutant found in familial amyotrophic lateral sclerosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=1885824

2 June 2018

Familial amyotrophic lateral sclerosis-associated mutations decrease the thermal stability of distinctly metallated species of human copper/zinc superoxide dismutase

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0703857104

21 January 2018

Kinetic stability of Cu/Zn superoxide dismutase is dependent on its metal ligands: implications for ALS.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0703857104

21 January 2018

Dissociation of human copper-zinc superoxide dismutase dimers using chaotrope and reductant. Insights into the molecular basis for dimer stability

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0703857104

21 January 2018

Monomeric Cu,Zn-superoxide dismutase is a common misfolding intermediate in the oxidation models of sporadic and familial amyotrophic lateral sclerosis.

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0703857104

21 January 2018

Fully metallated S134N Cu,Zn-superoxide dismutase displays abnormal mobility and intermolecular contacts in solution

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0703857104

21 January 2018

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0703857104

21 January 2018

MOLREP: an Automated Program for Molecular Replacement

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0703857104

21 January 2018

Comparison of simple potential functions for simulating liquid water

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0703857104

21 January 2018

Sequence and structural determinants of Cu, Zn superoxide dismutase aggregation

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0703857104

21 January 2018

Backbone Dynamics of Human Cu,Zn Superoxide Dismutase and of Its Monomeric F50E/G51E/E133Q Mutant: The Influence of Dimerization on Mobility and Function†

1 reference

https://api.crossref.org/works/10.1073%2FPNAS.0703857104

21 January 2018

Identifiers

10.1073/PNAS.0703857104

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2007PNAS..10410040S

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