(Q27647751)

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Conformational changes induced by a single amino acid substitution in thetrans-membrane domain of Vpu: Implications for HIV-1 susceptibility to channel blocking drugs

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Conformational changes induced by a single amino acid substitution in thetrans-membrane domain of Vpu: Implications for HIV-1 susceptibility to channel blocking drugs (English)

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Stanley J Opella

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Stanley J Opella

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Sang Ho Park

1

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publication date

October 2007

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Protein Science

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16

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10

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2205-15

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Backbone Structure of the Amantadine-Blocked Trans-Membrane Domain M2 Proton Channel from Influenza A Virus

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20 March 2017

Three-dimensional Structure of the Channel-forming Trans-membrane Domain of Virus Protein “u” (Vpu) from HIV-1

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20 March 2017

Structure of the coat protein in fd filamentous bacteriophage particles determined by solid-state NMR spectroscopy

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20 March 2017

Simultaneous assignment and structure determination of a membrane protein from NMR orientational restraints

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20 March 2017

The closed state of a H+ channel helical bundle combining precise orientational and distance restraints from solid state NMR

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20 March 2017

Structure of the transmembrane region of the M2 protein H+ channel

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20 March 2017

The Vpu protein of human immunodeficiency virus type 1 forms cation-selective ion channels

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20 March 2017

MOLMOL: a program for display and analysis of macromolecular structures

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20 March 2017

NMRPipe: a multidimensional spectral processing system based on UNIX pipes

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20 March 2017

The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue

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20 March 2017

Mutual functional destruction of HIV-1 Vpu and host TASK-1 channel

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20 March 2017

HIV-1 Vpu: putting a channel to the TASK

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20 March 2017

The chemical and dynamical influence of the anti-viral drug amantadine on the M2 proton channel transmembrane domain

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29 September 2017

Selective averaging for high-resolution solid-state NMR spectroscopy of aligned samples.

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29 September 2017

Structure determination of a membrane protein with two trans-membrane helices in aligned phospholipid bicelles by solid-state NMR spectroscopy

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29 September 2017

Molecular interactions investigated by multi-dimensional solid-state NMR.

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29 September 2017

Hexamethylene amiloride blocks E protein ion channels and inhibits coronavirus replication

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29 September 2017

HIV-1 Vpu promotes release and prevents endocytosis of nascent retrovirus particles from the plasma membrane

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29 September 2017

The pericentriolar recycling endosome plays a key role in Vpu-mediated enhancement of HIV-1 particle release

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29 September 2017

The M2 proton channels of influenza A and B viruses

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29 September 2017

Nuclear magnetic resonance structural studies of a potassium channel-charybdotoxin complex.

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29 September 2017

Substitution of the transmembrane domain of Vpu in simian-human immunodeficiency virus (SHIVKU1bMC33) with that of M2 of influenza A results in a virus that is sensitive to inhibitors of the M2 ion channel and is pathogenic for pig-tailed macaques

1 reference

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29 September 2017

Functional domains within the human immunodeficiency virus type 2 envelope protein required to enhance virus production

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29 September 2017

Potential new anti-human immunodeficiency virus type 1 compounds depress virus replication in cultured human macrophages

1 reference

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29 September 2017

Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride

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29 September 2017

Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production

1 reference

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29 September 2017

Roles of the histidine and tryptophan side chains in the M2 proton channel from influenza A virus

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29 September 2017

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29 September 2017

The HIV-1 Vpu protein: a multifunctional enhancer of viral particle release.

1 reference

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29 September 2017

Dipolar waves map the structure and topology of helices in membrane proteins.

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29 September 2017

Characterization of a novel simian immunodeficiency virus with a vpu gene from greater spot-nosed monkeys (Cercopithecus nictitans) provides new insights into simian/human immunodeficiency virus phylogeny

1 reference

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29 September 2017

Viral ion channels: structure and function.

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29 September 2017

Dipolar waves as NMR maps of protein structure

1 reference

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29 September 2017

Human immunodeficiency virus type 1 VPU protein affects Sindbis virus glycoprotein processing and enhances membrane permeabilization

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29 September 2017

A solid-state NMR index of helical membrane protein structure and topology.

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29 September 2017

Correlation of the structural and functional domains in the membrane protein Vpu from HIV-1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2204142

29 September 2017

Structural biology of HIV.

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29 September 2017

Effects of Vpu expression on Xenopus oocyte membrane conductance

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29 September 2017

Prediction of protein side-chain rotamers from a backbone-dependent rotamer library: a new homology modeling tool

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29 September 2017

The human immunodeficiency virus (HIV) type 2 envelope protein is a functional complement to HIV type 1 Vpu that enhances particle release of heterologous retroviruses.

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29 September 2017

Human immunodeficiency virus type 2 glycoprotein enhancement of particle budding: role of the cytoplasmic domain

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29 September 2017

The envelope glycoprotein of human immunodeficiency virus type 2 enhances viral particle release: a Vpu-like factor?

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29 September 2017

The two biological activities of human immunodeficiency virus type 1 Vpu protein involve two separable structural domains.

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29 September 2017

HIV accessory proteins: leading roles for the supporting cast.

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29 September 2017

Identification of a protein encoded by the vpu gene of HIV-1.

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29 September 2017

Molecular and biochemical analyses of human immunodeficiency virus type 1 vpu protein

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29 September 2017

Functional role of human immunodeficiency virus type 1 vpu.

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29 September 2017

Genetic organization of a chimpanzee lentivirus related to HIV-1.

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29 September 2017

Human immunodeficiency virus type 1 Vpu protein induces rapid degradation of CD4

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29 September 2017

Influenza virus M2 protein has ion channel activity

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29 September 2017

Protonation of histidine and histidine-tryptophan interaction in the activation of the M2 ion channel from influenza a virus

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2 June 2018

The human immunodeficiency virus type 1 Vpu protein enhances membrane permeability.

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2 June 2018

NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein

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2 June 2018

Do Vpu and Vpr of human immunodeficiency virus type 1 and NB of influenza B virus have ion channel activities in the viral life cycles?

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2 June 2018

HIV accessory proteins as therapeutic targets

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2 June 2018

A novel gene of HIV-1, vpu, and its 16-kilodalton product

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2 June 2018

NMR structural studies of interactions of a small, nonpeptidyl Tpo mimic with the thrombopoietin receptor extracellular juxtamembrane and transmembrane domains.

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27 November 2018

Drug-protein interaction with Vpu from HIV-1: proposing binding sites for amiloride and one of its derivatives.

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27 November 2018

A single amino acid substitution within the transmembrane domain of the human immunodeficiency virus type 1 Vpu protein renders simian-human immunodeficiency virus (SHIV(KU-1bMC33)) susceptible to rimantadine

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27 November 2018

Rotational diffusion of membrane proteins in aligned phospholipid bilayers by solid-state NMR spectroscopy.

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27 November 2018

Tilt angle of a trans-membrane helix is determined by hydrophobic mismatch

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27 November 2018

Channel activity of a viral transmembrane peptide in micro-BLMs: Vpu(1-32) from HIV-1.

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27 November 2018

Structure of the coat protein in Pf1 bacteriophage determined by solid-state NMR spectroscopy

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27 November 2018

Interaction of amiloride and one of its derivatives with Vpu from HIV-1: a molecular dynamics simulation

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27 November 2018

Sensitivity-enhanced IPAP experiments for measuring one-bond 13C'-13Calpha and 13Calpha-1Halpha residual dipolar couplings in proteins.

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27 November 2018

Dipolar Waves as NMR maps of helices in proteins

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27 November 2018

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27 November 2018

Amiloride derivatives block ion channel activity and enhancement of virus-like particle budding caused by HIV-1 protein Vpu.

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27 November 2018

Imaging Membrane Protein Helical Wheels

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27 November 2018

Ion channels formed by HIV-1 Vpu: a modelling and simulation study

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27 November 2018

Identification of an ion channel activity of the Vpu transmembrane domain and its involvement in the regulation of virus release from HIV-1-infected cells

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27 November 2018

Solid-state NMR in drug design and discovery for membrane-embedded targets

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Structure determination of membrane proteins by NMR spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17766368

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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10.1110/PS.073041107

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