(Q27649432)

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Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome

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scholarly article

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Structure analysis of bone morphogenetic protein-2 type I receptor complexes reveals a mechanism of receptor inactivation in juvenile polyposis syndrome (English)

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protein structure

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1 reference

based on heuristic

inferred from title

juvenile polyposis syndrome

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based on heuristic

inferred from title

Alexander Kotzsch

1

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7

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2

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Thomas Herrmann

object named as

Thomas Herrmann

6

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author name string

Axel Seher

3

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Kai Heinecke

4

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Laura van Geersdaele

5

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Thomas D Mueller

8

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language of work or name

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publication date

29 February 2008

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Journal of Biological Chemistry

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283

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9

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5876-87

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The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms

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TGF-beta signal transduction

1 reference

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Bone morphogenetic proteins in development

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706029200

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Bone morphogenetic proteins

1 reference

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Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A.

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Ventral mesodermal patterning in Xenopus embryos: expression patterns and activities of BMP-2 and BMP-4

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Bone morphogenetic proteins in the nervous system

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Sequential progression of the differentiation program by bone morphogenetic protein-2 in chondrogenic cell line ATDC5.

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Constitutively active BMP type I receptors transduce BMP-2 signals without the ligand in C2C12 myoblasts.

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Characterization of type I receptors for transforming growth factor-beta and activin

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Bone morphogenetic protein-5, -6 and -7 inhibit growth and induce apoptosis in human myeloma cells

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Differential roles for bone morphogenetic protein (BMP) receptor type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineages

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Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

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Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5

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Osteogenic protein-1 binds to activin type II receptors and induces certain activin-like effects

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Divergence and convergence of TGF-beta/BMP signaling

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A single residue of GDF-5 defines binding specificity to BMP receptor IB.

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Activating and deactivating mutations in the receptor interaction site of GDF5 cause symphalangism or brachydactyly type A2

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Familial primary pulmonary hypertension (gene PPH1) is caused by mutations in the bone morphogenetic protein receptor-II gene

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Mutations of the TGF-beta type II receptor BMPR2 in pulmonary arterial hypertension.

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Mutations in bone morphogenetic protein receptor 1B cause brachydactyly type A2

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A new era for fibrodysplasia ossificans progressiva: a druggable target for the second skeleton

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The prevalence of MADH4 and BMPR1A mutations in juvenile polyposis and absence of BMPR2, BMPR1B, and ACVR1 mutations

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706029200

21 January 2018

Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis.

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706029200

21 January 2018

Smad4 signalling in T cells is required for suppression of gastrointestinal cancer.

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Bone morphogenetic protein signaling is essential for terminal differentiation of the intestinal secretory cell lineage

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BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II

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Molecular recognition of BMP-2 and BMP receptor IA

1 reference

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Mutations in the SMAD4/DPC4 gene in juvenile polyposis

1 reference

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A sensitive and specific in vitro bioassay for activin using a mouse plasmacytoma cell line, MPC-11.

1 reference

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21 January 2018

Structurally adaptive hot spots at a protein interaction interface on TRAF3.

1 reference

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Structurally Distinct Recognition Motifs in Lymphotoxin-β Receptor and CD40 for Tumor Necrosis Factor Receptor-associated Factor (TRAF)-mediated Signaling

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Protein-protein interactions: structurally conserved residues distinguish between binding sites and exposed protein surfaces

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Multiple diverse ligands binding at a single protein site: a matter of pre-existing populations

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The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M706029200

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Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-beta ligand:receptor interactions

1 reference

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21 January 2018

High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: implications for ligand binding

1 reference

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Structure of the ternary signaling complex of a TGF-beta superfamily member

1 reference

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DRAGON, a bone morphogenetic protein co-receptor

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Role of transforming growth factor-beta signaling in cancer

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Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells

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Essential roles of BMPR-IA signaling in differentiation and growth of hair follicles and in skin tumorigenesis

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Bone morphogenetic protein 2 is expressed by, and acts upon, mature epithelial cells in the colon.

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The mutational spectrum of brachydactyly type C

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Identifiers

10.1074/JBC.M706029200

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