(Q27650432)

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Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding

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scholarly article

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Crystal structures of F420-dependent glucose-6-phosphate dehydrogenase FGD1 involved in the activation of the anti-tuberculosis drug candidate PA-824 reveal the basis of coenzyme and substrate binding (English)

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crystal structure

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Glucose-6-phosphate dehydrogenase

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1,5-dihydrocoenzyme F420-6

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ChEBI release 2020-05-28

coenzyme F420-6

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ChEBI release 2020-05-28

object named as

Ghader Bashiri

1

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object named as

Nicole J Moreland

3

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Christopher J Squire

object named as

Christopher J Squire

2

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object named as

Edward N Baker

4

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language of work or name

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publication date

20 June 2008

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Journal of Biological Chemistry

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283

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25

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17531-41

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Prospects for new antitubercular drugs

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https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis

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https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis

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https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Purification of a novel coenzyme F420-dependent glucose-6-phosphate dehydrogenase from Mycobacterium smegmatis

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https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Large-scale production of coenzyme F420-5,6 by using Mycobacterium smegmatis

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https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Tuberculosis - metabolism and respiration in the absence of growth

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https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Coenzyme binding in F420-dependent secondary alcohol dehydrogenase, a member of the bacterial luciferase family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Crystal structure of methylenetetrahydromethanopterin reductase (Mer) in complex with coenzyme F420: Architecture of the F420/FMN binding site of enzymes within the nonprolyl cis-peptide containing bacterial luciferase family

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Structures of F420H2:NADP+ oxidoreductase with and without its substrates bound

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https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Expression, purification and crystallization of native and selenomethionine labeled Mycobacterium tuberculosis FGD1 (Rv0407) using a Mycobacterium smegmatis expression system

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Processing of X-ray diffraction data collected in oscillation mode

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https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

The CCP4 suite: programs for protein crystallography

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https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Substructure solution with SHELXD

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https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

[27] Maximum-likelihood heavy-atom parameter refinement for multiple isomorphous replacement and multiwavelength anomalous diffraction methods.

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https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Methods used in the structure determination of bovine mitochondrial F1 ATPase

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https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

PHENIX: building new software for automated crystallographic structure determination

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Coot: model-building tools for molecular graphics

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https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Refinement of macromolecular structures by the maximum-likelihood method

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https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Use of TLS parameters to model anisotropic displacements in macromolecular refinement

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https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

PROCHECK: a program to check the stereochemical quality of protein structures

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Likelihood-enhanced fast translation functions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Improved protein-ligand docking using GOLD

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Structures of coenzyme F(420) in Mycobacterium species

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Inference of macromolecular assemblies from crystalline state

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

The 1.5-A resolution crystal structure of bacterial luciferase in low salt conditions

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Very fast empirical prediction and rationalization of protein pKa values

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Distortion of flavin geometry is linked to ligand binding in cholesterol oxidase

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Preclinical testing of the nitroimidazopyran PA-824 for activity against Mycobacterium tuberculosis in a series of in vitro and in vivo models

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Genes required for mycobacterial growth defined by high density mutagenesis

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

The proteasome of Mycobacterium tuberculosis is required for resistance to nitric oxide

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Changes in energy metabolism of Mycobacterium tuberculosis in mouse lung and under in vitro conditions affecting aerobic respiration

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding α-crystallin

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

ESPript/ENDscript: Extracting and rendering sequence and 3D information from atomic structures of proteins

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M801854200

21 January 2018

Identifiers

10.1074/JBC.M801854200

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