(Q27650721)

English

Crystal Structure of Thioflavin T Bound to the Peripheral Site of Torpedo californica Acetylcholinesterase Reveals How Thioflavin T Acts as a Sensitive Fluorescent Reporter of Ligand Binding to the Acylation Site

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scholarly article

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Crystal Structure of Thioflavin T Bound to the Peripheral Site of Torpedo californica Acetylcholinesterase Reveals How Thioflavin T Acts as a Sensitive Fluorescent Reporter of Ligand Binding to the Acylation Site (English)

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crystal structure

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1 reference

based on heuristic

inferred from title

Pacific electric ray

object named as

Torpedo californica

1 reference

based on heuristic

inferred from title

3

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Joel L. Sussman

object named as

Joel L Sussman

4

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author name string

Michal Harel

1

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Leilani K Sonoda

2

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Terrone L Rosenberry

5

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language of work or name

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publication date

25 June 2008

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Journal of the American Chemical Society

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130

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25

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7856-61

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Freeze-frame inhibitor captures acetylcholinesterase in a unique conformation

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

20 March 2017

Acetylcholinesterase complexed with bivalent ligands related to huperzine a: experimental evidence for species-dependent protein-ligand complementarity

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

20 March 2017

Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

20 March 2017

Structure of a complex of the potent and specific inhibitor BW284C51 with Torpedo californica acetylcholinesterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

20 March 2017

3D structure of Torpedo californica acetylcholinesterase complexed with huprine X at 2.1 A resolution: kinetic and molecular dynamic correlates

1 reference

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20 March 2017

Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs

1 reference

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20 March 2017

Structure of acetylcholinesterase complexed with the nootropic alkaloid, (-)-huperzine A

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

20 March 2017

Crystal structure of an acetylcholinesterase-fasciculin complex: interaction of a three-fingered toxin from snake venom with its target

1 reference

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20 March 2017

Acetylcholinesterase inhibition by fasciculin: crystal structure of the complex

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

20 March 2017

Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase

1 reference

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Coot: model-building tools for molecular graphics

1 reference

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20 March 2017

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

20 March 2017

Atomic Structure of Acetylcholinesterase from Torpedo californica : A Prototypic Acetylcholine-Binding Protein

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

20 March 2017

Interaction of fluorescence probes with acetylcholinesterase. Site and specificity of propidium binding

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

20 March 2017

Acetylcholinesterase: 'classical' and 'non-classical' functions and pharmacology

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

29 September 2017

Development of bivalent acetylcholinesterase inhibitors as potential therapeutic drugs for Alzheimer's disease.

1 reference

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Golden age of insecticide research: past, present, or future?

1 reference

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29 September 2017

Anticholinesterases: medical applications of neurochemical principles.

1 reference

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29 September 2017

Fasciculins, anticholinesterase toxins from the venom of the green mamba Dendroaspis angusticeps.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

29 September 2017

Structural insights into substrate traffic and inhibition in acetylcholinesterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

2 June 2018

Thioflavin T is a fluorescent probe of the acetylcholinesterase peripheral site that reveals conformational interactions between the peripheral and acylation sites.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

2 June 2018

Rapid assembly of Alzheimer-like paired helical filaments from microtubule-associated protein tau monitored by fluorescence in solution

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

2 June 2018

Allosteric modulation of acetylcholinesterase activity by peripheral ligands involves a conformational transition of the anionic subsite.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

2 June 2018

Catalysis by acetylcholinesterase. I. Fluorescent titration with a carbamoylating agent

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

2 June 2018

Site selectivity of fluorescent bisquaternary phenanthridinium ligands for acetylcholinesterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

2 June 2018

Complexes of Alkylene-Linked Tacrine Dimers withTorpedo californicaAcetylcholinesterase: Binding of Bis(5)-tacrine Produces a Dramatic Rearrangement in the Active-Site Gorge

1 reference

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27 November 2018

Crystal Packing Mediates Enantioselective Ligand Recognition at the Peripheral Site of Acetylcholinesterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3923376

27 November 2018

The crystal structure of the complex of the anticancer prodrug 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin (CPT-11) with Torpedo californica acetylcholinesterase provides a molecular explanation for its cholinergic action

1 reference

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The complex of a bivalent derivative of galanthamine with torpedo acetylcholinesterase displays drastic deformation of the active-site gorge: implications for structure-based drug design

1 reference

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Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica 1 1Edited by R. Huber

1 reference

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27 November 2018

Binding of 125I-fasciculin to rat brain acetylcholinesterase. The complex still binds diisopropyl fluorophosphate

1 reference

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Responses of acetylcholinesterase from Torpedo marmorata to salts and curarizing drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/18512913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The advantages of using a modified microbatch method for rapid screening of protein crystallization conditions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18512913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Purification and crystallization of a dimeric form of acetylcholinesterase from Torpedo californica subsequent to solubilization with phosphatidylinositol-specific phospholipase C

1 reference

https://pubmed.ncbi.nlm.nih.gov/18512913

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based on heuristic

inferred from PubMed ID database lookup

Nonequilibrium analysis alters the mechanistic interpretation of inhibition of acetylcholinesterase by peripheral site ligands

1 reference

https://pubmed.ncbi.nlm.nih.gov/18512913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18512913

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/18512913

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/JA7109822

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PubMed publication ID

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ResearchGate publication ID

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