(Q27651746)

6

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author name string

Jark Böttcher

1

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Andreas Blum

2

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Stefanie Dörr

3

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Andreas Heine

4

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Wibke E Diederich

3-year suppression of HIV viremia with indinavir, zidovudine, and lamivudine

5

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publication date

September 2008

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published in

ChemMedChem

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volume

3

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issue

9

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page(s)

1337-44

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cites work

1 reference

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Twenty years of therapy for HIV-1 infection.

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Overview of the effectiveness of triple combination therapy in antiretroviral-naive HIV-1 infected adults

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Active human immunodeficiency virus protease is required for viral infectivity

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7 January 2021

The Protein Data Bank: a computer-based archival file for macromolecular structures

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7 January 2021

X-ray analysis of HIV-1 proteinase at 2.7 A resolution confirms structural homology among retroviral enzymes

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7 January 2021

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

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7 January 2021

Structure of complex of synthetic HIV-1 protease with a substrate-based inhibitor at 2.3 A resolution

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7 January 2021

Design, activity, and 2.8 A crystal structure of a C2 symmetric inhibitor complexed to HIV-1 protease

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7 January 2021

How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease

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7 January 2021

1.9 A x-ray study shows closed flap conformation in crystals of tethered HIV-1 PR

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7 January 2021

Reaction path and free energy calculations of the transition between alternate conformations of HIV-1 protease

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7 January 2021

Solution structure of the mature HIV-1 protease monomer: insight into the tertiary fold and stability of a precursor

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7 January 2021

Rational design of inhibitors that bind to inactive kinase conformations

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7 January 2021

Structure-based inhibitors of HIV-1 protease

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7 January 2021

Thermodynamic rules for the design of high affinity HIV-1 protease inhibitors with adaptability to mutations and high selectivity towards unwanted targets

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7 January 2021

An old target revisited: two new privileged skeletons and an unexpected binding mode for HIV-protease inhibitors

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7 January 2021

Unexpected novel binding mode of pyrrolidine-based aspartyl protease inhibitors: design, synthesis and crystal structure in complex with HIV protease

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7 January 2021

Atypical protonation states in the active site of HIV-1 protease: a computational study

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7 January 2021

Pyrrolidine-based amino alcohols: novel ligands for the enantioselective alkylation of benzaldehyde

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7 January 2021

Conformational flexibility in the flap domains of ligand-free HIV protease

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7 January 2021

Inhibitor binding at the protein interface in crystals of a HIV-1 protease complex

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7 January 2021

Ultra-high resolution crystal structure of HIV-1 protease mutant reveals two binding sites for clinical inhibitor TMC114

1 reference

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7 January 2021

From nonpeptide toward noncarbon protease inhibitors: metallacarboranes as specific and potent inhibitors of HIV protease

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7 January 2021

Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity

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7 January 2021

"Wide-open" 1.3 A structure of a multidrug-resistant HIV-1 protease as a drug target

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7 January 2021

High-level expression and purification of mature HIV-1 protease in Escherichia coli under control of the araBAD promoter

1 reference

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7 January 2021

Likelihood-enhanced fast rotation functions

1 reference

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7 January 2021

Coot: model-building tools for molecular graphics

1 reference

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7 January 2021

A simple, continuous fluorometric assay for HIV protease

1 reference

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7 January 2021

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

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7 January 2021

Chiral pyrrolidine thioethers: effective nitrogen–sulfur donating ligands in palladium-catalyzed asymmetric allylic alkylations

1 reference

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7 January 2021