(Q27652070)

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Flexible Cyclic Ethers/Polyethers as Novel P2-Ligands for HIV-1 Protease Inhibitors: Design, Synthesis, Biological Evaluation, and Protein−Ligand X-ray Studies †

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18783203%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

Flexible cyclic ethers/polyethers as novel P2-ligands for HIV-1 protease inhibitors: design, synthesis, biological evaluation, and protein-ligand X-ray studies (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18783203%20AND%20SRC:MED&resulttype=core&format=json

14 January 2020

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14 January 2020

Andrey Kovalevsky

5

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14 January 2020

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Irene T Weber

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14 January 2020

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Arun K Ghosh

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14 January 2020

Abigail Baldridge

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14 January 2020

Yuan-Fang Wang

4

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14 January 2020

Yashiro Koh

6

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14 January 2020

Hiroaki Mitsuya

8

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14 January 2020

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11 September 2008

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14 January 2020

Journal of Medicinal Chemistry

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14 January 2020

51

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14 January 2020

19

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14 January 2020

6021-6033

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14 January 2020

Potent New Antiviral Compound Shows Similar Inhibition and Structural Interactions with Drug Resistant Mutants and Wild Type HIV-1 Protease †

1 reference

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20 March 2017

Structural implications of drug-resistant mutants of HIV-1 protease: high-resolution crystal structures of the mutant protease/substrate analogue complexes

1 reference

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20 March 2017

Crystal structure of an in vivo HIV-1 protease mutant in complex with saquinavir: Insights into the mechanisms of drug resistance

1 reference

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20 March 2017

The Protein Data Bank

1 reference

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SHELXL: high-resolution refinement

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The CCP4 suite: programs for protein crystallography

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A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site

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Why do patients fail HIV therapy?

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The impact of transmitted drug resistance on the natural history of HIV infection and response to first-line therapy

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29 September 2017

Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.

1 reference

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Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor

1 reference

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29 September 2017

Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy

1 reference

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Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.

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29 September 2017

Antiviral activity of UIC-PI, a novel inhibitor of the human immunodeficiency virus type 1 protease

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29 September 2017

Potent HIV protease inhibitors incorporating high-affinity P2-ligands and (R)-(hydroxyethylamino)sulfonamide isostere

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Changes in drug sensitivity of human immunodeficiency virus type 1 during therapy with azidothymidine, dideoxycytidine, and dideoxyinosine: an in vitro comparative study

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A simple, continuous fluorometric assay for HIV protease

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10.1021/JM8004543

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14 January 2020

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14 January 2020

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