(Q27652485)

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Structure and catalytic mechanism of human steroid 5β-reductase (AKR1D1)

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Structure and catalytic mechanism of human steroid 5β-reductase (AKR1D1) (English)

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1

Luigi Di Costanzo

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author name string

Jason E Drury

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2

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David W Christianson

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3

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Trevor M Penning

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4

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publication date

25 March 2009

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published in

Molecular and Cellular Endocrinology

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volume

301

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issue

1-2

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page(s)

191-8

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cites work

The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism

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PubMed Central

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20 March 2017

Crystal Structure of Human Liver 4-3-Ketosteroid 5 -Reductase (AKR1D1) and Implications for Substrate Binding and Catalysis

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PubMed Central

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20 March 2017

Structure and reactivity of human mitochondrial 2,4-dienoyl-CoA reductase: enzyme-ligand interactions in a distinctive short-chain reductase active site

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20 March 2017

Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase

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20 March 2017

Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+

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PubMed Central

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20 March 2017

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2675190

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7 April 2017

Cloning and expression of cDNA of human delta 4-3-oxosteroid 5 beta-reductase and substrate specificity of the expressed enzyme

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20 March 2017

The enzymes, regulation, and genetics of bile acid synthesis

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20 March 2017

Comparative anatomy of the aldo-keto reductase superfamily

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24 May 2017

Morphological aspects of oligomeric protein structures

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29 September 2017

Mutagenesis of 3 alpha-hydroxysteroid dehydrogenase reveals a "push-pull" mechanism for proton transfer in aldo-keto reductases

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29 September 2017

Purification and characterization of delta 4-3-ketosteroid 5 beta-reductase.

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29 September 2017

Molecular cloning and sequence analysis of cDNA encoding delta 4-3-ketosteroid 5 beta-reductase of rat liver

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29 September 2017

Bile acid biosynthesis

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29 September 2017

Electrostatic stabilization in a pre-organized polar active site: the catalytic role of Lys-80 in Candida tenuis xylose reductase (AKR2B5) probed by site-directed mutagenesis and functional complementation studies

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2 June 2018

Engineering steroid 5 beta-reductase activity into rat liver 3 alpha-hydroxysteroid dehydrogenase

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2 June 2018

Human Aldose Reductase: pK of Tyrosine 48 Reveals the Preferred Ionization State for Catalysis and Inhibition

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27 November 2018

Enzymatic mechanisms of hormone metabolism. I. Oxidation-reduction of the steroid nucleus

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12 December 2020

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Conversion of cholesterol to bile acids in rat: purification and properties of a delta-4-3-ketosteroid 5-beta-reductase and a 3-alpha-hydroxysteroid dehydrogenase

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PubMed

reference URL

https://pubmed.ncbi.nlm.nih.gov/18848863

retrieved

12 December 2020

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Identifiers

DOI

10.1016/J.MCE.2008.09.013

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PMC publication ID

2675190

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PubMed publication ID

18848863

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ResearchGate publication ID

23311850

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(Q27652485)

Structure and catalytic mechanism of human steroid 5β-reductase (AKR1D1)

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