(Q27741876)

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Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase

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5 November 2019

Steroid recognition and regulation of hormone action: crystal structure of testosterone and NADP+ bound to 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase (English)

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5 November 2019

crystal structure

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Trevor M Penning

5

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5 November 2019

author name string

M J Bennett

1

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5 November 2019

R H Albert

2

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5 November 2019

J M Jez

3

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5 November 2019

H Ma

4

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5 November 2019

M Lewis

6

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5 November 2019

publication date

1 June 1997

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5 November 2019

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5 November 2019

5

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5 November 2019

6

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5 November 2019

799-812

1 reference

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5 November 2019

Molecular cloning of human type 3 3 alpha-hydroxysteroid dehydrogenase that differs from 20 alpha-hydroxysteroid dehydrogenase by seven amino acids

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Substrate Specificity, Gene Structure, and Tissue-specific Distribution of Multiple Human 3α-Hydroxysteroid Dehydrogenases

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Structural and functional comparison of two human liver dihydrodiol dehydrogenases associated with 3 alpha-hydroxysteroid dehydrogenase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Bacterial morphine dehydrogenase further defines a distinct superfamily of oxidoreductases with diverse functional activities

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Short-chain dehydrogenases/reductases (SDR)

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Enzymes of Androgen Formation and Degradation in the Human Prostate

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

3 Alpha-hydroxysteroid oxidoreductase activities in dihydrotestosterone degradation and back-formation in rat prostate and epididymis

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Changes in Dihydrotestosterone Metabolism Associated with the Development of Canine Benign Prostatic Hyperplasia*

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Refined 1.8 A structure of human aldose reductase complexed with the potent inhibitor zopolrestat

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

1.7 .ANG. Structure of FR-1, a Fibroblast Growth Factor-Induced Member of the Aldo-Keto Reductase Family, Complexed with Coenzyme and Inhibitor

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning and characterization of mouse estradiol 17 beta-dehydrogenase (A-specific), a member of the aldoketoreductase family

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activity

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structure of human estrogenic 17 beta-hydroxysteroid dehydrogenase complexed with 17 beta-estradiol

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The structure of a complex of human 17beta-hydroxysteroid dehydrogenase with estradiol and NADP+ identifies two principal targets for the design of inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Crystal structures of the binary and ternary complexes of 7 alpha-hydroxysteroid dehydrogenase from Escherichia coli

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Phi/psi-chology: Ramachandran revisited

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase complexed with NADP+

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Three-dimensional structure of rat liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase: a member of the aldo-keto reductase superfamily

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Characterization of the substrate binding site in rat liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase. The roles of tryptophans in ligand binding and protein fluorescence

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Mammalian 3 alpha-hydroxysteroid dehydrogenases

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Structure of porcine aldehyde reductase holoenzyme.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The kinetic mechanism catalysed by homogeneous rat liver 3 alpha-hydroxysteroid dehydrogenase. Evidence for binary and ternary dead-end complexes containing non-steroidal anti-inflammatory drugs

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Novel NADPH-binding domain revealed by the crystal structure of aldose reductase

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Mechanism of human aldehyde reductase: characterization of the active site pocket

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

The fascinating complexities of steroid-binding enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Site-directed mutagenesis of the conserved tyrosine 151 of human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase yields a catalytically inactive enzyme

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Site-specific mutagenesis of Drosophila alcohol dehydrogenase: evidence for involvement of tyrosine-152 and lysine-156 in catalysis

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Tyr-179 and Lys-183 are essential for enzymatic activity of 11β-hydroxysteroid dehydrogenase

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Active site directed mutagenesis of 3 beta/17 beta-hydroxysteroid dehydrogenase establishes differential effects on short-chain dehydrogenase/reductase reactions

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Molecular cloning of testicular 20 alpha-hydroxysteroid dehydrogenase: identity with aldose reductase.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Purification and characterization of human-brain aldose reductase.

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

A comprehensive set of sequence analysis programs for the VAX

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

inferred from DOI database lookup

Raster3D Version 2.0. A program for photorealistic molecular graphics

1 reference

https://api.crossref.org/works/10.1016%2FS0969-2126%2897%2900234-7

7 January 2021

based on heuristic

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Identifiers

10.1016/S0969-2126(97)00234-7

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261071%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9261071%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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