(Q27652762)

4

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author name string

Neal K Williams

1

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Isabelle S Lucet

2

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S Peter Klinken

Journal of Biological Chemistry

3

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language of work or name

English

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publication date

2 January 2009

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published in

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volume

284

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page(s)

284-91

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issue

1

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cites work

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Src family kinases: regulation of their activities, levels and identification of new pathways

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JAKs, STATs and Src kinases in hematopoiesis

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Src family kinases, key regulators of signal transduction

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Lyn tyrosine kinase is essential for erythropoietin-induced differentiation of J2E erythroid cells

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Deficiency of Src family kinases Fgr and Hck results in activation of erythrocyte K/Cl cotransport

21 January 2018

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Lyn is a target gene for prostate cancer: sequence-based inhibition induces regression of human tumor xenografts

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Lyn deficiency reduces GATA-1, EKLF and STAT5, and induces extramedullary stress erythropoiesis.

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Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells

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Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors

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HS1 interacts with Lyn and is critical for erythropoietin-induced differentiation of erythroid cells

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Csk-binding protein mediates sequential enzymatic down-regulation and degradation of Lyn in erythropoietin-stimulated cells.

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Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1.

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Therapeutic targeting of Src-kinase Lyn in myeloid leukemic cell growth.

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BCR-ABL independence and LYN kinase overexpression in chronic myelogenous leukemia cells selected for resistance to STI571.

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Dual-specific Src and Abl kinase inhibitors, PP1 and CGP76030, inhibit growth and survival of cells expressing imatinib mesylate-resistant Bcr-Abl kinases

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Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis.

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A critical role for Lyn in acute myeloid leukemia.

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Lyn regulates BCR-ABL and Gab2 tyrosine phosphorylation and c-Cbl protein stability in imatinib-resistant chronic myelogenous leukemia cells

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Src family kinases phosphorylate the Bcr-Abl SH3-SH2 region and modulate Bcr-Abl transforming activity

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BCR-ABL-induced oncogenesis is mediated by direct interaction with the SH2 domain of the GRB-2 adaptor protein

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Short interfering RNA (siRNA) targeting the Lyn kinase induces apoptosis in primary, and drug-resistant, BCR-ABL1(+) leukemia cells

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Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling

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Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia

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Dasatinib in imatinib-resistant Philadelphia chromosome-positive leukemias

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Three-dimensional structure of the tyrosine kinase c-Src

21 January 2018

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Crystal structure of the Src family tyrosine kinase Hck

21 January 2018

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Crystal structure of Hck in complex with a Src family-selective tyrosine kinase inhibitor

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Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation

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Structural analysis of the lymphocyte-specific kinase Lck in complex with non-selective and Src family selective kinase inhibitors

21 January 2018

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Thyroid hormone receptor-interacting protein 1 modulates cytokine and nuclear hormone signaling in erythroid cells.

21 January 2018

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The structure of Dasatinib (BMS-354825) bound to activated ABL kinase domain elucidates its inhibitory activity against imatinib-resistant ABL mutants

21 January 2018

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Discovery of N-(2-chloro-6-methyl- phenyl)-2-(6-(4-(2-hydroxyethyl)- piperazin-1-yl)-2-methylpyrimidin-4- ylamino)thiazole-5-carboxamide (BMS-354825), a dual Src/Abl kinase inhibitor with potent antitumor activity in preclinical assays.

21 January 2018

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Overriding imatinib resistance with a novel ABL kinase inhibitor

21 January 2018

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Structural mechanism for STI-571 inhibition of abelson tyrosine kinase

21 January 2018

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Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl.

21 January 2018

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