(Q27653009)

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Crystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid Lipofuscinosis

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Crystal Structure and Autoactivation Pathway of the Precursor Form of Human Tripeptidyl-peptidase 1, the Enzyme Deficient in Late Infantile Ceroid Lipofuscinosis (English)

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crystal structure

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object named as

Ann M Stock

4

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object named as

Kalyan Das

3

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author name string

Jayita Guhaniyogi

1

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Istvan Sohar

2

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Peter Lobel

5

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language of work or name

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publication date

6 February 2009

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Journal of Biological Chemistry

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284

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6

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3985-97

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Structure of tripeptidyl-peptidase I provides insight into the molecular basis of late infantile neuronal ceroid lipofuscinosis

1 reference

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20 March 2017

Two inhibitor molecules bound in the active site of Pseudomonas sedolisin: a model for the bi-product complex following cleavage of a peptide substrate

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20 March 2017

A model of tripeptidyl-peptidase I (CLN2), a ubiquitous and highly conserved member of the sedolisin family of serine-carboxyl peptidases

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The 1.4 a crystal structure of kumamolysin: a thermostable serine-carboxyl-type proteinase

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20 March 2017

Inhibitor complexes of the Pseudomonas serine-carboxyl proteinase

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20 March 2017

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20 March 2017

Carboxyl proteinase from Pseudomonas defines a novel family of subtilisin-like enzymes

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20 March 2017

The human CLN2 protein/tripeptidyl-peptidase I is a serine protease that autoactivates at acidic pH

1 reference

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20 March 2017

Characterization of endopeptidase activity of tripeptidyl peptidase-I/CLN2 protein which is deficient in classical late infantile neuronal ceroid lipofuscinosis

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2635056

20 March 2017

Purification and characterization of bovine brain lysosomal pepstatin-insensitive proteinase, the gene product deficient in the human late-infantile neuronal ceroid lipofuscinosis

1 reference

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20 March 2017

Mutational analysis of the defective protease in classic late-infantile neuronal ceroid lipofuscinosis, a neurodegenerative lysosomal storage disorder

1 reference

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20 March 2017

Classical late infantile neuronal ceroid lipofuscinosis fibroblasts are deficient in lysosomal tripeptidyl peptidase I

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20 March 2017

Association of mutations in a lysosomal protein with classical late-infantile neuronal ceroid lipofuscinosis

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20 March 2017

Purification and characterization of a tripeptidyl peptidase I from human osteoclastomas: evidence for its role in bone resorption

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Optimal description of a protein structure in terms of multiple groups undergoing TLS motion

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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20 March 2017

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21 January 2018

Substructure solution with SHELXD

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20 March 2017

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29 September 2017

Maximum-likelihood density modification

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20 March 2017

Automated MAD and MIR structure solution

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20 March 2017

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20 March 2017

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20 March 2017

Production and characterization of recombinant human CLN2 protein for enzyme-replacement therapy in late infantile neuronal ceroid lipofuscinosis

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20 March 2017

Tripeptidyl-peptidase I is apparently the CLN2 protein absent in classical late-infantile neuronal ceroid lipofuscinosis

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20 March 2017

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20 March 2017

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Treatment of late infantile neuronal ceroid lipofuscinosis by CNS administration of a serotype 2 adeno-associated virus expressing CLN2 cDNA.

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Intracranial delivery of CLN2 reduces brain pathology in a mouse model of classical late infantile neuronal ceroid lipofuscinosis.

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21 January 2018

Intraventricular enzyme replacement improves disease phenotypes in a mouse model of late infantile neuronal ceroid lipofuscinosis

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21 January 2018

Maturation of human tripeptidyl-peptidase I in vitro

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21 January 2018

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21 January 2018

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21 January 2018

Ser475, Glu272, Asp276, Asp327, and Asp360 are involved in catalytic activity of human tripeptidyl-peptidase I.

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21 January 2018

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based on heuristic

inferred from PubMed ID database lookup

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10.1074/JBC.M806943200

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