(Q27655825)

English

Mutations of key hydrophobic surface residues of 11β-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system

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scholarly article

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Mutations of key hydrophobic surface residues of 11β-hydroxysteroid dehydrogenase type 1 increase solubility and monodispersity in a bacterial expression system (English)

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1 reference

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inferred from title

5

object named as

Paul M Stewart

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Alexander J. Lawson

object named as

Alexander J Lawson

1

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object named as

Scott A White

3

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author name string

Elizabeth A Walker

2

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Timothy R Dafforn

4

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Jonathan P Ride

6

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publication date

July 2009

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Protein Science

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18

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7

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1552-63

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Mammalian microsomal cytochrome P450 monooxygenase: structural adaptations for membrane binding and functional diversity

1 reference

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20 March 2017

Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

20 March 2017

Inference of macromolecular assemblies from crystalline state

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20 March 2017

UCSF Chimera--a visualization system for exploratory research and analysis

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20 March 2017

Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

1 reference

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20 March 2017

Automated protein model building combined with iterative structure refinement

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

20 March 2017

The N-terminal anchor sequences of 11beta-hydroxysteroid dehydrogenases determine their orientation in the endoplasmic reticulum membrane

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

20 March 2017

11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

20 March 2017

Experimentally determined hydrophobicity scale for proteins at membrane interfaces

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

7 April 2017

Demonstration of proof of mechanism and pharmacokinetics and pharmacodynamic relationship with 4'-cyano-biphenyl-4-sulfonic acid (6-amino-pyridin-2-yl)-amide (PF-915275), an inhibitor of 11 -hydroxysteroid dehydrogenase type 1, in cynomolgus monkeys

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

29 September 2017

Mechanisms of disease: Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 as a novel treatment for the metabolic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

29 September 2017

Comparative enzymology of 11beta-hydroxysteroid dehydrogenase type 1 from six species

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

29 September 2017

11beta-hydroxysteroid dehydrogenase and the pre-receptor regulation of corticosteroid hormone action

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

29 September 2017

Metabolic syndrome without obesity: Hepatic overexpression of 11beta-hydroxysteroid dehydrogenase type 1 in transgenic mice

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

29 September 2017

Transgenic amplification of glucocorticoid action in adipose tissue causes high blood pressure in mice

1 reference

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29 September 2017

Critical residues for structure and catalysis in short-chain dehydrogenases/reductases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

29 September 2017

11 Beta-hydroxysteroid dehydrogenase type 1 from human liver: dimerization and enzyme cooperativity support its postulated role as glucocorticoid reductase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

29 September 2017

A transgenic model of visceral obesity and the metabolic syndrome

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

29 September 2017

Forms and functions of human SDR enzymes

1 reference

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29 September 2017

Functional expression, characterization, and purification of the catalytic domain of human 11-beta -hydroxysteroid dehydrogenase type 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

29 September 2017

11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

29 September 2017

Expression of truncated forms of liver microsomal P450 cytochromes 2B4 and 2E1 in Escherichia coli: influence of NH2-terminal region on localization in cytosol and membranes

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

29 September 2017

Improved lipid and lipoprotein profile, hepatic insulin sensitivity, and glucose tolerance in 11beta-hydroxysteroid dehydrogenase type 1 null mice

1 reference

https://api.crossref.org/works/10.1002%2FPRO.150

21 January 2018

Selective inhibition of 11 beta-hydroxysteroid dehydrogenase type 1 improves hepatic insulin sensitivity in hyperglycemic mice strains

1 reference

https://api.crossref.org/works/10.1002%2FPRO.150

21 January 2018

Conformational flexibility in crystal structures of human 11beta-hydroxysteroid dehydrogenase type I provide insights into glucocorticoid interconversion and enzyme regulation

1 reference

https://api.crossref.org/works/10.1002%2FPRO.150

21 January 2018

Structural role of conserved Asn179 in the short-chain dehydrogenase/reductase scaffold

1 reference

https://api.crossref.org/works/10.1002%2FPRO.150

21 January 2018

The crystal structure of guinea pig 11beta-hydroxysteroid dehydrogenase type 1 provides a model for enzyme-lipid bilayer interactions

1 reference

https://api.crossref.org/works/10.1002%2FPRO.150

21 January 2018

Crystal structure of murine 11 beta-hydroxysteroid dehydrogenase 1: an important therapeutic target for diabetes

1 reference

https://api.crossref.org/works/10.1002%2FPRO.150

21 January 2018

Solubility engineering of the HhaI methyltransferase

1 reference

https://api.crossref.org/works/10.1002%2FPRO.150

21 January 2018

Structure-based substitutions for increased solubility of a designed protein

1 reference

https://api.crossref.org/works/10.1002%2FPRO.150

21 January 2018

Improving protein solubility through rationally designed amino acid replacements: solubilization of the trimethoprim-resistant type S1 dihydrofolate reductase.

1 reference

https://api.crossref.org/works/10.1002%2FPRO.150

21 January 2018

Disrupting the hydrophobic patches at the antibody variable/constant domain interface: improved in vivo folding and physical characterization of an engineered scFv fragment.

1 reference

https://api.crossref.org/works/10.1002%2FPRO.150

21 January 2018

Comparative enzymology of 11 beta -hydroxysteroid dehydrogenase type 1 from glucocorticoid resistant (Guinea pig) versus sensitive (human) species

1 reference

https://api.crossref.org/works/10.1002%2FPRO.150

21 January 2018

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

1 reference

https://api.crossref.org/works/10.1002%2FPRO.150

21 January 2018

High-level production and optimization of monodispersity of 11beta-hydroxysteroid dehydrogenase type 1.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2775222

27 November 2018

Human 11beta-hydroxysteroid dehydrogenase type 1 is enzymatically active in its nonglycosylated form

1 reference

https://pubmed.ncbi.nlm.nih.gov/19507261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Characterization of 11 beta-hydroxysteroid dehydrogenase gene expression: identification of multiple unique forms of messenger ribonucleic acid in the rat kidney

1 reference

https://pubmed.ncbi.nlm.nih.gov/19507261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lumenal orientation and post-translational modifications of the liver microsomal 11 beta-hydroxysteroid dehydrogenase

1 reference

https://pubmed.ncbi.nlm.nih.gov/19507261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Assay optimization and kinetic profile of the human and the rabbit isoforms of 11beta-HSD1

1 reference

https://pubmed.ncbi.nlm.nih.gov/19507261

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1002/PRO.150

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