(Q27657093)

2

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Christophe Briand

3

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Arnaud Decock

4

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Allan D'arcy

5

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Ulrich Hassiepen

6

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Richard Morse

7

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Martin Renatus

APP binds DR6 to trigger axon pruning and neuron death via distinct caspases

8

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language of work or name

English

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publication date

12 October 2009

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published in

Biochemical Journal

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volume

423

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issue

3

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page(s)

429-39

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cites work

1 reference

Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

21 April 2017

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Coot: model-building tools for molecular graphics

21 April 2017

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Use of non-crystallographic symmetry in protein structure refinement

21 April 2017

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A unified model for apical caspase activation

21 April 2017

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The Ced-3/interleukin 1beta converting enzyme-like homolog Mch6 and the lamin-cleaving enzyme Mch2alpha are substrates for the apoptotic mediator CPP32

21 April 2017

1 reference

Mechanism of XIAP-mediated inhibition of caspase-9

21 April 2017

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Structure and mechanism of interleukin-1 beta converting enzyme

21 April 2017

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The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity

21 April 2017

1 reference

An Allosteric Circuit in Caspase-1

21 April 2017

1 reference

Lysosomal proteases are involved in generation of N-terminal huntingtin fragments

21 April 2017

1 reference

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract

21 April 2017

1 reference

MOLREP: an Automated Program for Molecular Replacement

21 April 2017

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

Expanding roles of programmed cell death in mammalian neurodevelopment

21 April 2017

1 reference

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Mouse models of cell death

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

Targets of caspase-6 activity in human neurons and Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders

21 January 2018

1 reference

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Apoptosis in neural development and disease

21 January 2018

1 reference

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Caspase 6 activity initiates caspase 3 activation in cerebellar granule cell apoptosis.

21 January 2018

1 reference

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Activation of caspase-6 in aging and mild cognitive impairment

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

Mechanisms of neuronal cell death in Huntington's disease.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

Enzyme inhibition assays using fluorescence correlation spectroscopy: a new algorithm for the derivation of kcat/KM and Ki values at substrate concentrations much lower than the Michaelis constant.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

Measurement of the dead time of a fluorescence stopped-flow instrument

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

APRV - a program for automated data processing, refinement and visualization.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

Catalytic properties of the caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

Caspase-9 holoenzyme is a specific and optimal procaspase-3 processing machine

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

The proteolytic procaspase activation network: an in vitro analysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

pH effects on the stability and dimerization of procaspase-3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

Crystal structures of a ligand-free and malonate-bound human caspase-1: implications for the mechanism of substrate binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

Discovery of an allosteric site in the caspases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

FGF-2 promotes neurogenesis and neuroprotection and prolongs survival in a transgenic mouse model of Huntington's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

Brain-derived neurotrophic factor in neurodegenerative diseases

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540

Caspase 3-cleaved N-terminal fragments of wild-type and mutant huntingtin are present in normal and Huntington's disease brains, associate with membranes, and undergo calpain-dependent proteolysis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1042%2FBJ20090540