(Q27657915)

1

0 references

Zhu-Li Wan

2

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Ying-Chi Chu

3

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Hassan Aladdin

4

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Birgit Klaproth

5

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Meredith Choquette

6

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Qing-Xin Hua

7

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Robert B Mackin

8

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J Sunil Rao

9

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Panayotis G Katsoyannis

11

0 references

Peter Arvan

12

0 references

Michael A Weiss

Journal of Biological Chemistry

13

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language of work or name

English

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publication date

11 December 2009

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published in

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volume

284

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issue

50

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page(s)

35259-72

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cites work

Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Mechanism of insulin chain combination. Asymmetric roles of A-chain alpha-helices in disulfide pairing

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Structural origins of the functional divergence of human insulin-like growth factor-I and insulin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

A cavity-forming mutation in insulin induces segmental unfolding of a surrounding α-helix

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Crystal structure of human insulin-like growth factor-1: detergent binding inhibits binding protein interactions

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Structure of a protein in a kinetic trap

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

The structure of 2Zn pig insulin crystals at 1.5 A resolution

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Structure of insulin in 4-zinc insulin

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Improved methods for building protein models in electron density maps and the location of errors in these models

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

From Levinthal to pathways to funnels

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

The proprotein convertases

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

The role of assembly in insulin's biosynthesis

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Stress signaling from the lumen of the endoplasmic reticulum: coordination of gene transcriptional and translational controls

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

SURFNET: a program for visualizing molecular surfaces, cavities, and intermolecular interactions

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Proinsulin and the genetics of diabetes mellitus

7 April 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Seven mutations in the human insulin gene linked to permanent neonatal/infancy-onset diabetes mellitus

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Proinsulin maturation, misfolding, and proteotoxicity

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Insulin gene mutations as a cause of permanent neonatal diabetes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

29 September 2017

ER stress and diseases.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

The experimental survey of protein-folding energy landscapes

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

A conserved histidine in insulin is required for the foldability of human proinsulin: structure and function of an ALAB5 analog

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Chiral mutagenesis of insulin. Foldability and function are inversely regulated by a stereospecific switch in the B chain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Proinsulin disulfide maturation and misfolding in the endoplasmic reticulum

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Native-like partially folded conformations and folding process revealed in the N-terminal large fragments of staphylococcal nuclease: a study by NMR spectroscopy.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

A peptide model of insulin folding intermediate with one disulfide

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Role of the connecting peptide in insulin biosynthesis

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Proteotoxicity in the endoplasmic reticulum: lessons from the Akita diabetic mouse

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Protein structure and the spandrels of San Marco: insulin's receptor-binding surface is buttressed by an invariant leucine essential for its stability.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Linear extrapolation method of analyzing solvent denaturation curves

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Application of circular dichroism to study RNA folding transitions

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

The fundamentals of protein folding: bringing together theory and experiment

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

A mutation in the insulin 2 gene induces diabetes with severe pancreatic beta-cell dysfunction in the Mody mouse

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

How evolution makes proteins fold quickly

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Theory of protein folding: the energy landscape perspective

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Biosynthetic human proinsulin. Review of chemistry, in vitro and in vivo receptor binding, animal and human pharmacology studies, and clinical trial experience

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Proinsulin: a proposed three-dimensional structure

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

On the Role of the Proinsulin C-peptide

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Peptide models of four possible insulin folding intermediates with two disulfides.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

The response of T4 lysozyme to large-to-small substitutions within the core and its relation to the hydrophobic effect.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

"New view" of protein folding reconciled with the old through multiple unfolding simulations.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Protein folding coupled to disulphide bond formation

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Intracellular transport of proinsulin in pancreatic beta-cells. Structural maturation probed by disulfide accessibility

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Conformation of proinsulin. A comparison of insulin and proinsulin self-association at neutral pH.

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

NMR and photo-CIDNP studies of human proinsulin and prohormone processing intermediates with application to endopeptidase recognition

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

The insulin A and B chains contain structural information for the formation of the native molecule. Studies with protein disulphide-isomerase

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Protein folding funnels: the nature of the transition state ensemble

2 June 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Role of native disulfide bonds in the structure and activity of insulin-like growth factor 1: genetic models of protein-folding intermediates.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Effects of cysteine to serine substitutions in the two inter-chain disulfide bonds of insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

A protein caught in a kinetic trap: structures and stabilities of insulin disulfide isomers

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Insulin mutation screening in 1,044 patients with diabetes: mutations in the INS gene are a common cause of neonatal diabetes but a rare cause of diabetes diagnosed in childhood or adulthood

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Expression, purification, and PC1-mediated processing of (H10D, P28K, and K29P)-human proinsulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Photochemical crosslinking of bacteriophage T4 single-stranded DNA-binding protein (gp32) to oligo-p(dT)8: identification of phenylalanine-183 as the site of crosslinking

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

PROCHECK: a program to check the stereochemical quality of protein structures

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Oxidative refolding of insulin-like growth factor 1 yields two products of similar thermodynamic stability: a bifurcating protein-folding pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Putative disulfide-forming pathway of porcine insulin precursor during its refolding in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Activities of monomeric insulin analogs at position A8 are uncorrelated with their thermodynamic stabilities

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Relative helix-forming tendencies of nonpolar amino acids

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

In vitro refolding of human proinsulin. Kinetic intermediates, putative disulfide-forming pathway folding initiation site, and potential role of C-peptide in folding process

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Contribution of the conserved A16Leu to insulin foldability

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Possible involvement of the A20-A21 peptide bond in the expression of the biological activity of insulin. 2. [21-Asparagine diethylamide-A]insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Possible involvement of the A20-A21 peptide bond in the expression of the biological activity of insulin. 3. [21-Desasparagine,20-cysteine ethylamide-A]insulin and [21-desasparagine,20-cysteine 2,2,2-trifluoroethylamide-A]insulin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Dominant negative pathogenesis by mutant proinsulin in the Akita diabetic mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Misfolded proinsulin accumulates in expanded pre-Golgi intermediates and endoplasmic reticulum subdomains in pancreatic beta cells of Akita mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Decoding the cryptic active conformation of a protein by synthetic photoscanning: insulin inserts a detachable arm between receptor domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

Hiking in the energy landscape in sequence space: a bumpy road to good folders.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Contribution of folding steps involving the individual subunits of bacterial luciferase to the assembly of the active heterodimeric enzyme.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2787385

Monomeric insulins obtained by protein engineering and their medical implications

27 November 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M109.046888

1H NMR spectrum of the native human insulin monomer. Evidence for conformational differences between the monomer and aggregated forms

21 January 2018

1 reference

12 December 2020

Possible involvement of the A20-A21 peptide bond in the expression of the biological activity of insulin. 1. [21-Desasparagine,20-cysteinamide-A]insulin and [21-desasparagine,20-cysteine isopropylamide-A]insulin

1 reference

12 December 2020

Evidence for a precursor in the biosynthesis of insulin

1 reference

12 December 2020

Proinsulin and the biosynthesis of insulin

1 reference

12 December 2020

Disulfide exchange folding of insulin-like growth factor I

1 reference

12 December 2020

A novel locus, Mody4, distal to D7Mit189 on chromosome 7 determines early-onset NIDDM in nonobese C57BL/6 (Akita) mutant mice

1 reference

12 December 2020

Formation of the insulin-containing secretory granule core occurs within immature beta-granules

1 reference

12 December 2020

Hierarchical protein folding: asymmetric unfolding of an insulin analogue lacking the A7-B7 interchain disulfide bridge

1 reference

12 December 2020

Steric requirements at position B12 for high biological activity in insulin

1 reference

12 December 2020

Difference density quality (DDQ): a method to assess the global and local correctness of macromolecular crystal structures

1 reference

12 December 2020

Characteristic, activity and conformational studies of [A6-Ser, A11-Ser]-insulin

1 reference

12 December 2020

The folding nucleus of the insulin superfamily: a flexible peptide model foreshadows the native state

1 reference

12 December 2020

An overview of insulin evolution

1 reference

12 December 2020

Engineering stability of the insulin monomer fold with application to structure-activity relationships

1 reference

12 December 2020

Insulin and Proinsulin Conformation in Solution

1 reference

12 December 2020

Equilibrium denaturation of insulin and proinsulin

1 reference

12 December 2020

Two routes for producing human insulin utilizing recombinant DNA technology

1 reference

12 December 2020

Physical studies on proinsulin — Association behavior and conformation in solution

1 reference

12 December 2020

Toward the active conformation of insulin: stereospecific modulation of a structural switch in the B chain

1 reference

12 December 2020

Protein folding bottlenecks: A lattice Monte Carlo simulation

1 reference

12 December 2020

Hierarchical protein "un-design": insulin's intrachain disulfide bridge tethers a recognition alpha-helix

1 reference

12 December 2020

Chiral mutagenesis of insulin. Contribution of the B20-B23 beta-turn to activity and stability

1 reference

12 December 2020

Native and non-native structure in a protein-folding intermediate: spectroscopic studies of partially reduced IGF-I and an engineered alanine model

1 reference

12 December 2020

Synthesis and Biological Activity of Two Disulphide Bond Isomers of Human Insulin: [A7-A11 ,A6-B7-Cystine]- and [A6-A7,A11-B7-Cystine]insulin (Human)

1 reference

12 December 2020

Probing the disulfide folding pathway of insulin-like growth factor-I

1 reference

12 December 2020

Heteronuclear 2D NMR studies of an engineered insulin monomer: assignment and characterization of the receptor-binding surface by selective 2H and 13C labeling with application to protein design

1 reference

12 December 2020

Folding of insulin-like growth factor I is thermodynamically controlled by insulin-like growth factor binding protein

1 reference

12 December 2020

Human insulin from a precursor overexpressed in the methylotrophic yeast Pichia pastoris and a simple procedure for purifying the expression product

1 reference

12 December 2020

Factors that affect the folding ability of proteins

1 reference

12 December 2020

Disulfide exchange folding of disulfide mutants of insulin-like growth factor I in vitro

1 reference

12 December 2020

Alanine scanning mutagenesis of insulin

1 reference

12 December 2020