(Q27659045)

1

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Iain D Kerr

2

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Kimberly T Barrett

3

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Nobuhiro Fuchi

4

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Moumita Debnath

5

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Kenny Ang

6

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Juan C Engel

7

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Patricia S Doyle

9

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Linda S Brinen

10

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Jonathan A Ellman

Journal of Medicinal Chemistry

11

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language of work or name

English

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publication date

25 February 2010

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published in

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volume

53

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issue

4

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page(s)

1763-73

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cites work

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Vinyl Sulfones as Antiparasitic Agents and a Structural Basis for Drug Design

20 March 2017

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A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection

20 March 2017

1 reference

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MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

20 March 2017

1 reference

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Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain

20 March 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease

20 March 2017

1 reference

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Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection

20 March 2017

1 reference

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Coot: model-building tools for molecular graphics

20 March 2017

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Refinement of macromolecular structures by the maximum-likelihood method

20 March 2017

1 reference

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

20 March 2017

1 reference

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

1 reference

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Irreversible inhibitors of serine, cysteine, and threonine proteases

20 March 2017

1 reference

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A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

20 March 2017

1 reference

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Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis)

20 March 2017

1 reference

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An automated system to mount cryo-cooled protein crystals on a synchrotron beam line, using compact sample cassettes and a small-scale robot

20 March 2017

1 reference

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Two approaches to discovering and developing new drugs for Chagas disease.

7 April 2017

1 reference

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Elimination of Chagas disease transmission: perspectives

29 September 2017

1 reference

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Approaches for the development of new anti-Trypanosoma cruzi agents.

29 September 2017

1 reference

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Identification of a new class of nonpeptidic inhibitors of cruzain

29 September 2017

1 reference

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Peptidomimetics via copper-catalyzed azide-alkyne cycloadditions.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

Drug discovery and development for neglected parasitic diseases

29 September 2017

1 reference

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Protease inhibitors in the clinic.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

Heterocyclic peptide backbone modifications in an alpha-helical coiled coil

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

The growing impact of click chemistry on drug discovery

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

Molecular properties that influence the oral bioavailability of drug candidates

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

Rapid and general profiling of protease specificity by using combinatorial fluorogenic substrate libraries

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

Cysteine protease inhibitors as chemotherapy for parasitic infections

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

Bimodal inhibition of caspase-1 by aryloxymethyl and acyloxymethyl ketones

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

Structural determinants of specificity in the cysteine protease cruzain

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

Susceptibility and natural resistance of Trypanosoma cruzi strains to drugs used clinically in Chagas disease

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

Peptidyl (acyloxy)methyl ketones and the quiescent affinity label concept: the departing group as a variable structural element in the design of inactivators of cysteine proteinases

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

Chagas' disease: facts and reality

2 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

Identification of selective, nonpeptidic nitrile inhibitors of cathepsin s using the substrate activity screening method

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

Asymmetric synthesis of alpha,alpha-dibranched propargylamines by acetylide additions to N-tert-butanesulfinyl ketimines.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

1,2,3-triazole as a peptide surrogate in the rapid synthesis of HIV-1 protease inhibitors

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

The cysteine protease of Trypanosoma cruzi as a model for antiparasite drug design

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

Improved solid-phase peptide synthesis method utilizing alpha-azide-protected amino acids.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

In vitro evaluation of the disposition of A novel cysteine protease inhibitor.

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

The crystal structure of cruzain: a therapeutic target for Chagas' disease

27 November 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2838180

Trypanosoma cruzi targets for new chemotherapeutic approaches

27 November 2018

1 reference

12 December 2020

A catalytic mechanism for caspase-1 and for bimodal inhibition of caspase-1 by activated aspartic ketones

1 reference

12 December 2020

Peptide-fluoromethyl ketones arrest intracellular replication and intercellular transmission of Trypanosoma cruzi

1 reference

12 December 2020

Theoretical and practical aspects of proteinase inhibition kinetics

1 reference

12 December 2020

Clinical Trial of the Pan-Caspase Inhibitor, IDN-6556, in Human Liver Preservation Injury

1 reference

12 December 2020