(Q27661770)

English

Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases

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scholarly article

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Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases (English)

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structural biology

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Veronika Harmat

4

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author name string

Eniko Takács

1

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Gergely Nagy

2

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Ibolya Leveles

3

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Anna Lopata

5

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Judit Tóth

6

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Beáta G Vértessy

7

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language of work or name

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publication date

16 July 2010

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584

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14

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3047-54

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Molecular shape and prominent role of beta-strand swapping in organization of dUTPase oligomers

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

20 March 2017

Keeping uracil out of DNA: physiological role, structure and catalytic mechanism of dUTPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

20 March 2017

Active site of mycobacterial dUTPase: structural characteristics and a built-in sensor

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

20 March 2017

Methylene substitution at the alpha-beta bridging position within the phosphate chain of dUDP profoundly perturbs ligand accommodation into the dUTPase active site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

20 March 2017

Active site closure facilitates juxtaposition of reactant atoms for initiation of catalysis by human dUTPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

20 March 2017

Atomic resolution structure of Escherichia coli dUTPase determined ab initio

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

20 March 2017

Human dUTP pyrophosphatase: uracil recognition by a beta hairpin and active sites formed by three separate subunits

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

20 March 2017

Crystal structure of a dUTPase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

20 March 2017

Coot: model-building tools for molecular graphics

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

20 March 2017

Refinement of macromolecular structures by the maximum-likelihood method

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

20 March 2017

dUTP pyrophosphatase is an essential enzyme in Saccharomyces cerevisiae

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

20 March 2017

The role of dUTPase and uracil-DNA repair in cancer chemotherapy

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

20 March 2017

Altered subunit communication in subfamilies of trimeric dUTPases

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

20 March 2017

Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

20 March 2017

Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

20 March 2017

Functional analysis of the Mycobacterium tuberculosis FAD-dependent thymidylate synthase, ThyX, reveals new amino acid residues contributing to an extended ThyX motif.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

29 September 2017

Catalytic and structural role of the metal ion in dUTP pyrophosphatase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

29 September 2017

Glycine rich P-loop motif in deoxyuridine pyrophosphatase

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

29 September 2017

Lethality of a dut (deoxyuridine triphosphatase) mutation in Escherichia coli

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

29 September 2017

Kinetic characterization of dUTPase from Escherichia coli.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

2 June 2018

Specific derivatization of the active site tyrosine in dUTPase perturbs ligand binding to the active site

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

2 June 2018

Identification of tyrosine as a functional residue in the active site of Escherichia coli dUTPase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2922844

2 June 2018

Altered active site flexibility and a structural metal-binding site in eukaryotic dUTPase: kinetic characterization, folding, and crystallographic studies of the homotrimeric Drosophila enzyme.

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.05.018

21 January 2018

dUTPase as a platform for antimalarial drug design: structural basis for the selectivity of a class of nucleoside inhibitors.

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.05.018

21 January 2018

Structural insights into the catalytic mechanism of phosphate ester hydrolysis by dUTPase

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.05.018

21 January 2018

A double role for a strictly conserved serine: further insights into the dUTPase catalytic mechanism

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.05.018

21 January 2018

Automatic processing of rotation diffraction data from crystals of initially unknown symmetry and cell constants

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.05.018

21 January 2018

MOLREP: an Automated Program for Molecular Replacement

1 reference

https://api.crossref.org/works/10.1016%2FJ.FEBSLET.2010.05.018

21 January 2018

The complete triphosphate moiety of non-hydrolyzable substrate analogues is required for a conformational shift of the flexible C-terminus in E. coli dUTP pyrophosphatase

1 reference

https://pubmed.ncbi.nlm.nih.gov/20493855

12 December 2020

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10.1016/J.FEBSLET.2010.05.018

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