(Q27665164)

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Structure-Based Design, Synthesis, and Structure−Activity Relationship Studies of HIV-1 Protease Inhibitors Incorporating Phenyloxazolidinones

scientific article published on November 11, 2010

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Structure-Based Design, Synthesis, and Structure−Activity Relationship Studies of HIV-1 Protease Inhibitors Incorporating Phenyloxazolidinones (English)

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Structure-based design, synthesis, and structure-activity relationship studies of HIV-1 protease inhibitors incorporating phenyloxazolidinones (English)

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20958050

5 August 2024

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molecular model

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20958050

5 August 2024

Celia A. Schiffer

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Celia A Schiffer

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Akbar Ali

1

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Saima Ghafoor Anjum

4

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Hong Cao

5

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G. S Kiran Kumar Reddy

2

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20958050

5 August 2024

Madhavi N. L. Nalam

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20958050

5 August 2024

Tariq M. Rana

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20958050

5 August 2024

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11 November 2010

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20958050

5 August 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20958050/?tool=EBI

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20958050

5 August 2024

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20958050/pdf/?tool=EBI

Portable Document Format

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content deliverer

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20958050

5 August 2024

https://europepmc.org/articles/PMC2996262

online access status

content deliverer

Europe PubMed Central

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20958050

5 August 2024

https://europepmc.org/articles/PMC2996262?pdf=render

Portable Document Format

online access status

content deliverer

Europe PubMed Central

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20958050

5 August 2024

https://doi.org/10.1021/jm1008743

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?resulttype=core&format=json&query=SRC%3AMED%20AND%20EXT_ID%3A20958050

5 August 2024

https://pubs.acs.org/doi/pdf/10.1021/jm1008743

1 reference

10.1021/JM1008743

https://api.crossref.org/works/10.1021/JM1008743

5 August 2024

Journal of Medicinal Chemistry

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53

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21

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7699-708

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Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance

1 reference

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1 reference

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1 reference

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Discovery of HIV-1 protease inhibitors with picomolar affinities incorporating N-aryl-oxazolidinone-5-carboxamides as novel P2 ligands

1 reference

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Lack of synergy for inhibitors targeting a multi-drug-resistant HIV-1 protease

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How does a symmetric dimer recognize an asymmetric substrate? A substrate complex of HIV-1 protease

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Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators

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A medicinal chemist's guide to molecular interactions

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29 September 2017

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Do enthalpy and entropy distinguish first in class from best in class?

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29 September 2017

Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel

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29 September 2017

HIV-1 drug resistance mutations: an updated framework for the second decade of HAART

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29 September 2017

Overview of boosted protease inhibitors in treatment-experienced HIV-infected patients

1 reference

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29 September 2017

Genotypic changes in human immunodeficiency virus type 1 protease associated with reduced susceptibility and virologic response to the protease inhibitor tipranavir

1 reference

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29 September 2017

TMC114, a novel human immunodeficiency virus type 1 protease inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates

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Discovery and selection of TMC114, a next generation HIV-1 protease inhibitor

1 reference

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Pharmacological and therapeutic properties of ritonavir-boosted protease inhibitor therapy in HIV-infected patients

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Novel bis-tetrahydrofuranylurethane-containing nonpeptidic protease inhibitor (PI) UIC-94017 (TMC114) with potent activity against multi-PI-resistant human immunodeficiency virus in vitro.

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10.1021/JM1008743

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release_3dbghlzrenaohlmsvwp3tunw24

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