(Q27665385)

2

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Arthur F Monzingo

3

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Walter Fast

4

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Jon D Robertus

Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide

5

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language of work or name

1 reference

3 January 2011

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published in

ChemMedChem

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volume

6

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issue

1

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page(s)

81-8

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cites work

1 reference

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Promiscuous Partitioning of a Covalent Intermediate Common in the Pentein Superfamily

20 March 2017

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MolProbity: all-atom contacts and structure validation for proteins and nucleic acids

20 March 2017

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Disruption of methylarginine metabolism impairs vascular homeostasis

20 March 2017

1 reference

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Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines

20 March 2017

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Phasercrystallographic software

20 March 2017

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Coot: model-building tools for molecular graphics

20 March 2017

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PHENIX: building new software for automated crystallographic structure determination

20 March 2017

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Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

20 March 2017

1 reference

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Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

20 March 2017

1 reference

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Calculation of protein extinction coefficients from amino acid sequence data

20 March 2017

1 reference

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A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes

20 March 2017

1 reference

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Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

20 March 2017

1 reference

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Assessment of phase accuracy by cross validation: the free R value. Methods and applications

20 March 2017

1 reference

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Spontaneous α-N-6-Phosphogluconoylation of a “His Tag” inEscherichia coli:The Cause of Extra Mass of 258 or 178 Da in Fusion Proteins

7 April 2017

1 reference

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Modulating the NO generating system from a medicinal chemistry perspective: current trends and therapeutic options in cardiovascular disease.

24 May 2017

1 reference

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Targeted inhibition of inducible nitric oxide synthase inhibits growth of human melanoma in vivo and synergizes with chemotherapy

29 September 2017

1 reference

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A click chemistry mediated in vivo activity probe for dimethylarginine dimethylaminohydrolase

29 September 2017

1 reference

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Dimethylarginine dimethylaminohydrolase (DDAH): expression, regulation, and function in the cardiovascular and renal systems

29 September 2017

1 reference

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Asymmetric dimethylarginine (ADMA): a novel risk marker in cardiovascular medicine and beyond

29 September 2017

1 reference

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Asymmetric dimethylarginine (ADMA): the silent transition from an 'uraemic toxin' to a global cardiovascular risk molecule

29 September 2017

1 reference

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Nitric oxide and cancer: an introduction

29 September 2017

1 reference

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Role of nitric oxide in tumour progression: lessons from human tumours

29 September 2017

1 reference

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Roles of nitric oxide in tumor growth

29 September 2017

1 reference

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Transition state analog inhibitors and enzyme catalysis

29 September 2017

1 reference

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Therapy of cancer metastasis by activation of the inducible nitric oxide synthase

29 September 2017

1 reference

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Selective targeting of nitric oxide synthase inhibitors to system y+ in activated macrophages.

2 June 2018

1 reference

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Benzoylamidoacetonitrile as an inhibitor of papain

2 June 2018

1 reference

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Structure-activity relationship of novel and known inhibitors of human dimethylarginine dimethylaminohydrolase-1: alkenyl-amidines as new leads.

2 June 2018

1 reference

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Inhibition of human dimethylarginine dimethylaminohydrolase-1 by S-nitroso-L-homocysteine and hydrogen peroxide. Analysis, quantification, and implications for hyperhomocysteinemia

27 November 2018

1 reference

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Inhibition of papain by nitriles: mechanistic studies using NMR and kinetic measurements

27 November 2018

1 reference

12 December 2020

Benzoylamidoacetonitrile is bound as a thioimidate in the active site of papain

1 reference

12 December 2020

Dimethylarginine dimethylaminohydrolase regulation: a novel therapeutic target in cardiovascular disease

1 reference

12 December 2020

Design of isoform-selective inhibitors of nitric oxide synthase

1 reference

12 December 2020

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

1 reference

12 December 2020

Substrate-assisted cysteine deprotonation in the mechanism of dimethylargininase (DDAH) from Pseudomonas aeruginosa

1 reference

12 December 2020

Near-infrared fluorescence detection permits accurate imaging of loading controls for Western blot analysis

1 reference

12 December 2020

Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FCMDC.201000392

7 January 2021

inferred from DOI database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

Crossref

https://api.crossref.org/works/10.1002%2FCMDC.201000392

7 January 2021