(Q24321779)

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Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide

scientific article

Developing Dual and Specific Inhibitors of Dimethylarginine Dimethylaminohydrolase-1 and Nitric Oxide Synthase: Toward a Targeted Polypharmacology To Control Nitric Oxide

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Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide (English)

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Dimethylarginine dimethylaminohydrolase 1

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GOA release 2020-03-11

dimethylargininase activity

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GOA release 2020-03-11

author name string

Yun Wang

1

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Arthur F Monzingo

2

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Shougang Hu

3

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Tera H Schaller

4

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Jon D Robertus

5

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Walter Fast

6

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language of work or name

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publication date

15 September 2009

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48

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36

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8624-35

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Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases

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Regulation of nitric oxide synthesis by dimethylarginine dimethylaminohydrolase

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Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase

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Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases

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Promiscuous Partitioning of a Covalent Intermediate Common in the Pentein Superfamily

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Disruption of methylarginine metabolism impairs vascular homeostasis

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Structural characterization and kinetics of nitric-oxide synthase inhibition by novel N5-(iminoalkyl)- and N5-(iminoalkenyl)-ornithines

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Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase

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Crystallographic studies on endothelial nitric oxide synthase complexed with nitric oxide and mechanism-based inhibitors

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Phasercrystallographic software

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UCSF Chimera--a visualization system for exploratory research and analysis

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PHENIX: building new software for automated crystallographic structure determination

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19 March 2017

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

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19 March 2017

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746464

19 March 2017

Calculation of protein extinction coefficients from amino acid sequence data

1 reference

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Improved methods for building protein models in electron density maps and the location of errors in these models

1 reference

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19 March 2017

Network pharmacology: the next paradigm in drug discovery

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Can we rationally design promiscuous drugs?

1 reference

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Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

1 reference

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19 March 2017

Dimethylarginine dimethylaminohydrolase I enhances tumour growth and angiogenesis

1 reference

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Assessment of phase accuracy by cross validation: the free R value. Methods and applications

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7 April 2017

Spontaneous α-N-6-Phosphogluconoylation of a “His Tag” inEscherichia coli:The Cause of Extra Mass of 258 or 178 Da in Fusion Proteins

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26 May 2017

Design of selective neuronal nitric oxide synthase inhibitors for the prevention and treatment of neurodegenerative diseases

1 reference

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27 September 2017

Discovery of highly potent and selective inhibitors of neuronal nitric oxide synthase by fragment hopping.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746464

27 September 2017

The role of nitric oxide in tumour progression

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Designed multiple ligands. An emerging drug discovery paradigm

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27 September 2017

Selective substrate-based inhibitors of mammalian dimethylarginine dimethylaminohydrolase.

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746464

27 September 2017

Characterization of a transient covalent adduct formed during dimethylarginine dimethylaminohydrolase catalysis

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746464

27 September 2017

The DDAH/ADMA/NOS pathway

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Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence

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Effects of overexpression of dimethylarginine dimethylaminohydrolase on tumor angiogenesis assessed by susceptibility magnetic resonance imaging.

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27 September 2017

Chemical basis of inflammation-induced carcinogenesis

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27 September 2017

Nitric oxide and cancer: an introduction

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27 September 2017

The role of nitric oxide in cancer

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27 September 2017

Blocking NO synthesis: how, where and why?

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27 September 2017

Novel, nonpeptidic cyanamides as potent and reversible inhibitors of human cathepsins K and L.

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27 September 2017

Aminoguanidine-mediated inactivation and alteration of neuronal nitric-oxide synthase

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27 September 2017

Biological significance of endogenous methylarginines that inhibit nitric oxide synthases

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27 September 2017

L-arginine binding to nitric-oxide synthase. The role of H-bonds to the nonreactive guanidinium nitrogens

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Roles of nitric oxide in tumor growth

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27 September 2017

Purification and properties of a new enzyme, NG,NG-dimethylarginine dimethylaminohydrolase, from rat kidney

1 reference

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Selective targeting of nitric oxide synthase inhibitors to system y+ in activated macrophages.

1 reference

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30 May 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746464

30 May 2018

L-N6-(1-iminoethyl)lysine: a selective inhibitor of inducible nitric oxide synthase.

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30 May 2018

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29 November 2018

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29 November 2018

A continuous spectrophotometric assay for dimethylarginine dimethylaminohydrolase

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29 November 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746464

29 November 2018

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1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2746464

29 November 2018

Molecular replacement by evolutionary search.

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29 November 2018

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29 November 2018

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1 reference

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29 November 2018

A colorimetric 96-well microtiter plate assay for the determination of enzymatically formed citrulline

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663506

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based on heuristic

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Characterization and Manipulation of the Pseudomonas aeruginosa Dimethylarginine Dimethylaminohydrolase Monomer–Dimer Equilibrium

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663506

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based on heuristic

inferred from PubMed ID database lookup

Evaluation of enzyme inhibitors in drug discovery. A guide for medicinal chemists and pharmacologists

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663506

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19663506

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Processing of X-ray diffraction data collected in oscillation mode

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663506

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of papain by nitriles: mechanistic studies using NMR and kinetic measurements

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663506

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19663506

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inferred from PubMed ID database lookup

Arginine deiminase: demonstration of two active sites and possible half-of-the-sites reactivity

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663506

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based on heuristic

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19663506

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based on heuristic

inferred from PubMed ID database lookup

N-nitro-L-arginine and N-monomethyl-L-arginine exhibit a different pattern of inactivation toward the three nitric oxide synthases

1 reference

https://pubmed.ncbi.nlm.nih.gov/19663506

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based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19663506

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

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1 reference

https://pubmed.ncbi.nlm.nih.gov/19663506

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based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1021/BI9007098

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